The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 3969222)

Published in Biochem J on April 15, 2014

Authors

Aaron Butt1, Victoria A Higman2, Christopher Williams2, Matthew P Crump2, Claudia M Hemsley1, Nicholas Harmer1, Richard W Titball1

Author Affiliations

1: *Biosciences, College of Life and Environmental Sciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, U.K.
2: †School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K.

Articles citing this

Toxin-Antitoxin Systems in Clinical Pathogens. Toxins (Basel) (2016) 0.86

Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of Yersinia pestis. J Bacteriol (2014) 0.82

What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence? Front Microbiol (2016) 0.81

Identification and Characterization of the HicAB Toxin-Antitoxin System in the Opportunistic Pathogen Pseudomonas aeruginosa. Toxins (Basel) (2016) 0.80

Activation of Toxin-Antitoxin System Toxins Suppresses Lethality Caused by the Loss of σE in Escherichia coli. J Bacteriol (2015) 0.78

Type II Toxin-Antitoxin Distribution and Adaptive Aspects on Xanthomonas Genomes: Focus on Xanthomonas citri. Front Microbiol (2016) 0.78

Characterization of in vitro phenotypes of Burkholderia pseudomallei and Burkholderia mallei strains potentially associated with persistent infection in mice. Arch Microbiol (2016) 0.77

Specific Gene Loci of Clinical Pseudomonas putida Isolates. PLoS One (2016) 0.76

The In vitro Antibiotic Tolerant Persister Population in Burkholderia pseudomallei is Altered by Environmental Factors. Front Microbiol (2015) 0.76

Wake me when it's over - Bacterial toxin-antitoxin proteins and induced dormancy. Exp Biol Med (Maywood) (2016) 0.76

Two stable variants of Burkholderia pseudomallei strain MSHR5848 express broadly divergent in vitro phenotypes associated with their virulence differences. PLoS One (2017) 0.75

Identification of a VapBC toxin-antitoxin system in a thermophilic bacterium Thermus thermophilus HB27. Extremophiles (2016) 0.75

Formation of persisters in Streptococcus mutans biofilms induced by antibacterial dental monomer. J Mater Sci Mater Med (2017) 0.75

Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirements. PLoS Pathog (2017) 0.75

Articles cited by this

NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94

SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol (1995) 74.88

Protein production by auto-induction in high density shaking cultures. Protein Expr Purif (2005) 29.74

The CCPN data model for NMR spectroscopy: development of a software pipeline. Proteins (2005) 13.03

BioMagResBank. Nucleic Acids Res (2007) 10.21

Persister cells, dormancy and infectious disease. Nat Rev Microbiol (2006) 8.35

Persister cells. Annu Rev Microbiol (2010) 7.24

The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data. Nucleic Acids Res (2004) 7.21

Melioidosis. N Engl J Med (2012) 6.94

Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol (2006) 6.34

Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J Bacteriol (2004) 5.82

Evaluating protein structures determined by structural genomics consortia. Proteins (2007) 5.45

Flagellin A is essential for the virulence of Vibrio anguillarum. J Bacteriol (1996) 5.38

Persister cells and tolerance to antimicrobials. FEMS Microbiol Lett (2004) 5.23

Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells. Proc Natl Acad Sci U S A (1986) 5.00

Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest. Science (2003) 4.55

Persisters: a distinct physiological state of E. coli. BMC Microbiol (2006) 4.03

The Biology Workbench--a seamless database and analysis environment for the biologist. Proteins (1998) 3.68

Bacterial persistence by RNA endonucleases. Proc Natl Acad Sci U S A (2011) 3.52

Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol (2010) 3.12

Toxin-antitoxin systems in bacteria and archaea. Annu Rev Genet (2011) 2.99

Signaling-mediated bacterial persister formation. Nat Chem Biol (2012) 2.96

Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Mol Microbiol (2003) 2.92

Regulatory RNA as mediator in GacA/RsmA-dependent global control of exoproduct formation in Pseudomonas fluorescens CHA0. J Bacteriol (2002) 2.86

Melioidosis: a clinical overview. Br Med Bull (2011) 2.83

Melioidosis: acute and chronic disease, relapse and re-activation. Trans R Soc Trop Med Hyg (2000) 2.71

Bacterial persistence and toxin-antitoxin loci. Annu Rev Microbiol (2012) 2.28

HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. J Bacteriol (2008) 2.26

Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: effects on macromolecular synthesis and persister formation. J Bacteriol (2006) 2.17

The molecular and cellular basis of pathogenesis in melioidosis: how does Burkholderia pseudomallei cause disease? FEMS Microbiol Rev (2009) 1.98

Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies. J Med Microbiol (2011) 1.90

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat Chem Biol (2012) 1.67

Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli. Biochem Biophys Res Commun (2009) 1.62

The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria. Bioinformatics (2006) 1.60

Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate. FEMS Microbiol Lett (2013) 1.54

The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA. Mol Microbiol (2008) 1.53

CING: an integrated residue-based structure validation program suite. J Biomol NMR (2012) 1.52

Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis (2009) 1.49

Crystal structure of an archaeal intein-encoded homing endonuclease PI-PfuI. J Mol Biol (2000) 1.46

Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules. J Bacteriol (2010) 1.35

Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Mol Microbiol (2010) 1.24

New-found fundamentals of bacterial persistence. Trends Microbiol (2012) 1.22

The frequency of persisters in Escherichia coli reflects the kinetics of awakening from dormancy. J Bacteriol (2010) 1.22

The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance. J Bacteriol (2010) 1.21

Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners. Curr Opin Struct Biol (2011) 1.20

A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance. J Bacteriol (2012) 1.05

Identification of the first functional toxin-antitoxin system in Streptomyces. PLoS One (2012) 1.00

Persistent gastric colonization with Burkholderia pseudomallei and dissemination from the gastrointestinal tract following mucosal inoculation of mice. PLoS One (2012) 0.97

ARIA for solution and solid-state NMR. Methods Mol Biol (2012) 0.94

Relaxed cleavage specificity within the RelE toxin family. J Bacteriol (2013) 0.92

Survival of bactericidal antibiotic treatment by a persister subpopulation of Listeria monocytogenes. Appl Environ Microbiol (2013) 0.87

Escherichia coli toxin gene hipA affects biofilm formation and DNA release. Microbiology (2013) 0.81

Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett (2012) 0.80

Reduced susceptibility of Malaysian clinical isolates of Burkholderia pseudomallei to ciprofloxacin. Trop Biomed (2011) 0.77