The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review).

PubWeight™: 0.88‹?›

🔗 View Article (PMC 3977811)

Published in Int J Oncol on February 03, 2014

Authors

Eliene Bogaerts1, Femke Heindryckx2, Yves-Paul Vandewynckel1, Leo A Van Grunsven3, Hans Van Vlierberghe1

Author Affiliations

1: Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 9000 Gent, Belgium.
2: Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.
3: Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, 1090 Brussels, Belgium.

Articles cited by this

Global cancer statistics. CA Cancer J Clin (2011) 185.92

Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27

Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04

Wnt signaling and cancer. Genes Dev (2000) 18.53

Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell (2009) 16.06

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med (2006) 6.31

Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology (2007) 5.75

EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology (2008) 5.53

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem (2004) 5.05

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94

Notch signaling: the core pathway and its posttranslational regulation. Dev Cell (2009) 4.49

Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A (2008) 4.20

CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene (2007) 3.96

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96

Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis (2007) 3.75

CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer (2007) 3.65

Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology (2012) 3.34

Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology (2011) 3.19

Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology (2004) 3.09

Management of HCC. J Hepatol (2012) 3.03

Notch signaling controls liver development by regulating biliary differentiation. Development (2009) 2.93

The canals of Hering and hepatic stem cells in humans. Hepatology (1999) 2.93

Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene (2006) 2.65

Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res (2007) 2.63

The hepatic stem cell niche: identification by label-retaining cell assay. Hepatology (2008) 2.56

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev (2011) 2.53

Non-Smad signaling pathways. Cell Tissue Res (2011) 2.52

Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes. Hepatology (2012) 2.49

HIF induces human embryonic stem cell markers in cancer cells. Cancer Res (2011) 2.46

Liver stem cells and hepatocellular carcinoma. Hepatology (2009) 2.27

Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med (2013) 2.20

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev (2011) 2.17

Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res (2008) 1.98

Identification of adult hepatic progenitor cells capable of repopulating injured rat liver. Hepatology (2008) 1.93

Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res (2003) 1.92

Combined hepatocellular-cholangiocarcinoma. A histologic and immunohistochemical study. Cancer (1985) 1.82

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Res (2011) 1.78

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med (2011) 1.74

Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology (2012) 1.71

TGF-β signalling and its role in cancer progression and metastasis. Cancer Metastasis Rev (2012) 1.67

Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway. Hepatology (2010) 1.66

Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Hepatology (2011) 1.65

Cancer stem cells: in the line of fire. Cancer Treat Rev (2012) 1.60

Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology (2008) 1.56

Notch signaling: emerging molecular targets for cancer therapy. Biochem Pharmacol (2010) 1.54

Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res (2011) 1.53

Hepatocyte antigen as a marker of hepatocellular carcinoma: an immunohistochemical comparison to carcinoembryonic antigen, CD10, and alpha-fetoprotein. Am J Surg Pathol (2002) 1.45

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Mol Cancer (2009) 1.44

Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut (2009) 1.44

Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. Hepatology (2013) 1.41

Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence. Cancer Sci (2003) 1.36

A critical role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell (2013) 1.30

Combined hepatocellular-cholangiocarcinoma: a histopathologic, immunohistochemical, and in situ hybridization study. Am J Surg Pathol (2002) 1.29

Hepatic stem cells. J Pathol (2002) 1.29

Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver. Hepatology (2010) 1.29

Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinoma. Br J Cancer (2009) 1.28

Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling. Carcinogenesis (2013) 1.22

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int (2010) 1.21

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo. Cytokine Growth Factor Rev (2011) 1.21

Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in mice. Gastroenterology (2011) 1.19

The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. Am J Physiol Gastrointest Liver Physiol (2008) 1.18

Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence. Am J Pathol (2009) 1.18

An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells. Clin Cancer Res (2009) 1.16

The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers. Cell Res (2011) 1.10

Biology of hepatic cancer stem cells. J Gastroenterol Hepatol (2011) 1.07

Notch signaling mediates TGF-β1-induced epithelial-mesenchymal transition through the induction of Snai1. Int J Biochem Cell Biol (2012) 1.06

Are we missing the target? Cancer stem cells and drug resistance in non-small cell lung cancer. Cancer Genomics Proteomics (2012) 1.05

Combined hepatocellular carcinoma and cholangiocarcinoma: clinical features, treatment modalities, and prognosis. Ann Surg Oncol (2012) 1.05

CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma. J Gastroenterol (2010) 1.04

Expression of leukemia inhibitory factor and its receptor during liver regeneration in the adult rat. Lab Invest (1996) 1.04

Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma. Hepatology (2011) 1.04

C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice. Gastroenterology (2008) 1.03

CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma. BMC Cancer (2011) 1.02

Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture. Hepatology (2012) 1.02

Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice. Hepatology (2012) 1.02

Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury. Am J Pathol (2011) 1.01

Mixed phenotype hepatocellular carcinoma after transarterial chemoembolization and liver transplantation. Liver Transpl (2011) 1.01

Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFβ signaling. PLoS One (2013) 0.99

Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. Mol Cancer Res (2010) 0.98

The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. J Cell Physiol (2011) 0.97

Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective. Cancer Lett (2009) 0.97

The quest for liver progenitor cells: a practical point of view. J Hepatol (2009) 0.95

A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition. Hepatology (2012) 0.95

Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways. Carcinogenesis (2012) 0.95

Hepatic stellate cells' involvement in progenitor-mediated liver regeneration. Lab Invest (2010) 0.92

Smads and chromatin modulation. Cytokine Growth Factor Rev (2005) 0.91

The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model. J Hepatol (2012) 0.90

Prognosis of hepatocellular carcinoma expressing cytokeratin 19: comparison with other liver cancers. World J Gastroenterol (2012) 0.90

Hepatocellular carcinoma. Lancet (2012) 0.89

Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol (2011) 0.89

Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice. J Hepatol (2012) 0.86

Hepatic non-parenchymal cells and extracellular matrix participate in oval cell-mediated liver regeneration. World J Gastroenterol (2009) 0.85

Transforming growth factor-beta signaling and liver cancer stem cell. Hepatol Res (2009) 0.79

Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model. Eur J Gastroenterol Hepatol (2012) 0.78