PolyP and APC fight a RAGEing battle.

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Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood (2011) 3.25

Histones induce rapid and profound thrombocytopenia in mice. Blood (2011) 2.66

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost (2011) 2.51

Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation. Blood (2012) 1.46

Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood (2011) 1.22

Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood (2012) 1.14

Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. J Thromb Haemost (2013) 1.10

Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor. Blood (2013) 0.96

Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma. Proc Natl Acad Sci U S A (2010) 0.95