Published in Blood on November 19, 2013
HMGB1 in health and disease. Mol Aspects Med (2014) 1.67
Emerging roles for platelets as immune and inflammatory cells. Blood (2014) 1.56
Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor. Blood (2016) 0.83
Sepsis and ARDS: The Dark Side of Histones. Mediators Inflamm (2015) 0.83
Inorganic polyphosphate elicits pro-inflammatory responses through activation of the mammalian target of rapamycin complexes 1 and 2 in vascular endothelial cells. J Thromb Haemost (2015) 0.78
Polyphosphate as modulator of hemostasis, thrombosis, and inflammation. J Thromb Haemost (2015) 0.78
Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin. Blood (2016) 0.78
Inorganic polyphosphate promotes cyclin D1 synthesis through activation of mTOR/Wnt/β-catenin signaling in endothelial cells. J Thromb Haemost (2016) 0.78
Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays. Blood (2015) 0.77
Anti-inflammatory functions of protein C require RAGE and ICAM-1 in a stimulus-dependent manner. Mediators Inflamm (2014) 0.77
Engineering D-helix of antithrombin in alpha-1-proteinase inhibitor confers antiinflammatory properties on the chimeric serpin. Thromb Haemost (2014) 0.76
PolyP and APC fight a RAGEing battle. Blood (2014) 0.75
Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells. J Cell Mol Med (2017) 0.75
Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70
HMG-1 as a late mediator of endotoxin lethality in mice. Science (1999) 17.72
The immunopathogenesis of sepsis. Nature (2002) 11.83
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol (2005) 11.57
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol (2007) 8.33
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
The cytoprotective protein C pathway. Blood (2006) 5.75
Inorganic polyphosphate: a molecule of many functions. Annu Rev Biochem (1999) 5.71
Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A (2010) 5.69
Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol (2003) 5.46
Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science (2002) 5.35
Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression. Lancet Infect Dis (2012) 5.14
Understanding RAGE, the receptor for advanced glycation end products. J Mol Med (Berl) (2005) 4.96
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J Clin Invest (2004) 3.89
Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Blood (2002) 3.70
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med (2007) 3.35
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood (2011) 3.25
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology (2011) 1.94
RAGE: therapeutic target and biomarker of the inflammatory response--the evidence mounts. J Leukoc Biol (2009) 1.84
Polyphosphate elicits pro-inflammatory responses that are counteracted by activated protein C in both cellular and animal models. J Thromb Haemost (2012) 1.71
Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem (2010) 1.48
Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation. Blood (2012) 1.46
RAGE: a single receptor fits multiple ligands. Trends Biochem Sci (2011) 1.39
Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1. Mol Immunol (2005) 1.39
Clinical relevance of circulating nucleosomes in cancer. Ann N Y Acad Sci (2008) 1.23
Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood (2011) 1.22
Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun (2013) 1.05
Bench to bedside: HMGB1-a novel proinflammatory cytokine and potential therapeutic target for septic patients in the emergency department. Acad Emerg Med (2004) 1.01
Molecular circuits in thrombosis and inflammation. Thromb Haemost (2013) 1.00
Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis. Autoimmunity (2012) 0.98
Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Development (2005) 2.25
Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci U S A (2007) 1.87
cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol Cell Biol (2004) 1.71
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54
Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster. J Nutr (2008) 1.47
The influence of sodium ion binding on factor IXa activity. Thromb Haemost (2006) 1.47
Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand. Thromb Haemost (2008) 1.35
Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma (2007) 1.35
Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties. J Biol Chem (2007) 1.34
Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Proc Natl Acad Sci U S A (2008) 1.30
Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C. Biochemistry (2002) 1.22
Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood (2011) 1.22
Role of basic residues of the autolysis loop in the catalytic function of factor Xa. Biochemistry (2002) 1.22
Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. J Biol Chem (2008) 1.15
Ixolaris: a factor Xa heparin-binding exosite inhibitor. Biochem J (2005) 1.14
Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/Xa. Protein Sci (2004) 1.12
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood (2009) 1.11
Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns. J Nutr (2007) 1.11
Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex. J Biol Chem (2003) 1.09
Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A. J Biol Chem (2004) 1.08
Identification of factor Xa residues critical for interaction with protein Z-dependent protease inhibitor: both active site and exosite interactions are required for inhibition. J Biol Chem (2005) 1.07
Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J Biol Chem (2010) 1.07
Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin. Proc Natl Acad Sci U S A (2003) 1.07
Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin. J Biol Chem (2007) 1.06
The little elongation complex regulates small nuclear RNA transcription. Mol Cell (2011) 1.06
Localization of the heparin binding exosite of factor IXa. J Biol Chem (2002) 1.04
Exosite-dependent regulation of factor VIIIa by activated protein C. Blood (2003) 1.04
Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1. J Biol Chem (2007) 1.04
Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C. Thromb Haemost (2009) 1.02
Localization of phosphatidylserine binding sites to structural domains of factor Xa. J Biol Chem (2001) 1.02
In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Mol Cell Biol (2004) 1.01
Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase. J Cell Physiol (2009) 0.98
One- and two-metal ion catalysis: global single-turnover kinetic analysis of the PvuII endonuclease mechanism. Biochemistry (2008) 0.97
FRET studies with factor X mutants provide insight into the topography of the membrane-bound factor X/Xa. Biochem J (2007) 0.97
Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development. Mol Cell Biol (2006) 0.97
Contribution of basic residues of the autolysis loop to the substrate and inhibitor specificity of factor IXa. J Biol Chem (2003) 0.97
Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor. Biochemistry (2009) 0.96
Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite. Protein Sci (2007) 0.95
The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster. Chromosoma (2011) 0.95
Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C. Proc Natl Acad Sci U S A (2006) 0.94
The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding. J Biol Chem (2004) 0.93
Calcium-binding sites of the thrombin-thrombomodulin-protein C complex: possible implications for the effect of platelet factor 4 on the activation of vitamin K-dependent coagulation factors. Thromb Haemost (2007) 0.93
Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa. J Biol Chem (2008) 0.93
Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor. J Biol Chem (2011) 0.92
Heparin-activated antithrombin interacts with the autolysis loop of target coagulation proteases. Blood (2004) 0.92
Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster. Mol Cell Biol (2005) 0.90
The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C. J Biol Chem (2003) 0.90
Role of the N-terminal epidermal growth factor-like domain of factor X/Xa. J Biol Chem (2004) 0.90
Identification of a basic region on tissue factor that interacts with the first epidermal growth factor-like domain of factor X. Biochemistry (2007) 0.90
Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury. Thromb Haemost (2014) 0.88
Mutations of the anti-mullerian hormone gene in patients with persistent mullerian duct syndrome: biosynthesis, secretion, and processing of the abnormal proteins and analysis using a three-dimensional model. Mol Endocrinol (2003) 0.87
Characterization of the heparin-binding site of the protein z-dependent protease inhibitor. Biochemistry (2012) 0.87
The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell (2013) 0.86
Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin. J Biol Chem (2003) 0.86
Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain. J Biol Chem (2004) 0.86
Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombin. J Cell Biochem (2012) 0.86
Thrombin inhibits HMGB1-mediated proinflammatory signaling responses when endothelial protein C receptor is occupied by its natural ligand. BMB Rep (2013) 0.85
Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase. Thromb Haemost (2012) 0.85
Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex. Biochemistry (2009) 0.85
The cofactor function of the N-terminal domain of tissue factor. J Biol Chem (2004) 0.85
Phosphatidylserine-induced factor Xa dimerization and binding to factor Va are competing processes in solution. Biochemistry (2012) 0.85
Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin. Biochemistry (2004) 0.84
Expression, purification and characterization of factor IX derivatives using a novel vector system. Protein Expr Purif (2006) 0.84