CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 3938054)

Published in Open Biol on February 12, 2014

Authors

Puneet Sharma1, Alo Nag

Author Affiliations

1: Department of Biochemistry, University of Delhi, South Campus, New Delhi, India.

Articles cited by this

(truncated to the top 100)

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol (1999) 15.63

RING domain E3 ubiquitin ligases. Annu Rev Biochem (2009) 12.55

Protein degradation and protection against misfolded or damaged proteins. Nature (2003) 10.19

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature (2011) 9.30

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature (2009) 8.44

The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res (2004) 8.23

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature (2011) 7.92

Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol (2004) 7.10

The ubiquitin code. Annu Rev Biochem (2012) 7.08

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem (1983) 7.03

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep (2008) 6.21

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell (2008) 6.07

Transcriptional regulation and function during the human cell cycle. Nat Genet (2001) 5.89

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol (2012) 5.71

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51

Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol (2009) 5.41

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell (2003) 4.97

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature (2006) 4.96

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science (2002) 4.95

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science (2001) 4.82

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell (1999) 4.53

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell (1996) 4.11

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell (2008) 4.09

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol (2009) 3.95

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell (2005) 3.85

Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol (2004) 3.72

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase. Cell Cycle (2007) 3.66

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature (2007) 3.59

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev (2008) 3.49

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol (2006) 3.49

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study. Lancet Oncol (2012) 3.35

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science (2004) 3.28

Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. PLoS Pathog (2008) 3.27

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol (2004) 3.14

CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature (2003) 3.07

Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat Cell Biol (2003) 3.04

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell (2002) 3.03

Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature (2007) 2.97

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol Cell (2002) 2.92

A new NEDD8-ligating system for cullin-4A. Genes Dev (1998) 2.82

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell (2009) 2.79

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell (2005) 2.75

DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev (2006) 2.75

The PCI domain: a common theme in three multiprotein complexes. Trends Biochem Sci (1998) 2.73

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction. PLoS Pathog (2008) 2.72

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev (2008) 2.71

Covalent modification of all members of human cullin family proteins by NEDD8. Oncogene (1999) 2.67

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Proc Natl Acad Sci U S A (2006) 2.66

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. J Biol Chem (2008) 2.63

PHOSIDA 2011: the posttranslational modification database. Nucleic Acids Res (2010) 2.61

Identification, analysis, and prediction of protein ubiquitination sites. Proteins (2010) 2.53

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1. Proc Natl Acad Sci U S A (2007) 2.50

Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components. Virology (2002) 2.50

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood (2002) 2.48

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell (2008) 2.47

Direct and indirect effects of UV radiation on DNA and its components. J Photochem Photobiol B (2001) 2.46

L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. Cell Cycle (2006) 2.37

CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol Cell (2010) 2.32

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase. Cell (2006) 2.31

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29

Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases. J Virol (2005) 2.17

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Cell (2011) 2.16

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell (2013) 2.14

PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis. Mol Cancer Ther (2002) 2.11

A field guide to ubiquitylation. Cell Mol Life Sci (2004) 2.09

Contrasting structural impacts induced by cis-syn cyclobutane dimer and (6-4) adduct in DNA duplex decamers: implication in mutagenesis and repair activity. Photochem Photobiol (1995) 2.07

TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology (2002) 2.05

The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells. Mol Cell Biol (2001) 2.04

Cullin 4A associates with the UV-damaged DNA-binding protein DDB. J Biol Chem (1999) 2.04

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. J Virol (1995) 1.95

STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol (2003) 1.95

The ubiquitin system, an immense realm. Annu Rev Biochem (2012) 1.88

The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res (1998) 1.88

Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res Rev (2010) 1.84

COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature (2011) 1.83

UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation. J Biol Chem (2001) 1.83

Viral avoidance and exploitation of the ubiquitin system. Nat Cell Biol (2009) 1.77

The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol (2011) 1.67

Neurotoxicity of bortezomib therapy in multiple myeloma: a single-center experience and review of the literature. Cancer (2007) 1.66

Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol (2006) 1.62

The role of HOX genes in normal hematopoiesis and acute leukemia. Leukemia (2012) 1.61

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev (2008) 1.61

DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res (2009) 1.60

A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat Struct Mol Biol (2009) 1.58

Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J Virol (2005) 1.56

Viral modulators of cullin RING ubiquitin ligases: culling the host defense. Sci STKE (2006) 1.54

L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle (2006) 1.53

Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle (2006) 1.51

CUL-4A is critical for early embryonic development. Mol Cell Biol (2002) 1.51

Unexpected cardiotoxicity in haematological bortezomib treated patients. Br J Haematol (2007) 1.48

Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Genes Dev (2010) 1.46

iSNO-PseAAC: predict cysteine S-nitrosylation sites in proteins by incorporating position specific amino acid propensity into pseudo amino acid composition. PLoS One (2013) 1.45

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep (2009) 1.44

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. Blood (2006) 1.43

Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res (2004) 1.40

GPS-SNO: computational prediction of protein S-nitrosylation sites with a modified GPS algorithm. PLoS One (2010) 1.40

DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res (2009) 1.34