Published in Mol Cell Biol on April 01, 2006
CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. J Biol Chem (2008) 2.63
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1. Proc Natl Acad Sci U S A (2007) 2.50
C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Curr Biol (2007) 1.85
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest. J Virol (2007) 1.77
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DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res (2009) 1.60
Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood (2008) 1.52
E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia (2006) 1.49
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res (2013) 1.48
ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. EMBO Mol Med (2011) 1.47
Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. Trends Cell Biol (2011) 1.46
Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res (2009) 1.37
The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Mol Cell Biol (2006) 1.31
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev (2008) 1.27
Cul4A is an oncogene in malignant pleural mesothelioma. J Cell Mol Med (2011) 1.21
DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci U S A (2007) 1.20
Proliferation defects and genome instability in cells lacking Cul4A. Oncogene (2009) 1.05
Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair. Nucleic Acids Res (2007) 1.03
Cancer models in Caenorhabditis elegans. Dev Dyn (2010) 0.98
Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1. J Biol Chem (2010) 0.96
Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. J Biol Chem (2007) 0.95
The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase. Cytokine (2010) 0.93
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Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. J Biol Chem (2011) 0.89
The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2008) 0.87
Cul4A is required for hematopoietic stem-cell engraftment and self-renewal. Blood (2007) 0.86
Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27. Cell Cycle (2011) 0.84
Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. PLoS One (2012) 0.82
The COP9 signalosome interacts with and regulates interferon regulatory factor 5 protein stability. Mol Cell Biol (2012) 0.82
The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications. Oncotarget (2015) 0.80
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IKK-β/NF-κB p65 mediates p27(Kip1) protein degradation in arsenite response. Biochem Biophys Res Commun (2014) 0.77
CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1. PLoS One (2015) 0.77
Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma. PLoS One (2015) 0.77
p27 is regulated independently of Skp2 in the absence of Cdk2. Biochim Biophys Acta (2013) 0.77
Wnt-induced proteolytic targeting. Genes Dev (2008) 0.76
Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos. PLoS One (2015) 0.75
Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex. Mol Biol Cell (2015) 0.75
CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway. Biologics (2017) 0.75
Purification of the COP9 signalosome complex and binding partners from human T cells. OMICS (2012) 0.75
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A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle. Cell Cycle (2016) 0.75
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miR-181a-2 downregulates the E3 ubiquitin ligase CUL4A transcript and promotes cell proliferation. Med Oncol (2017) 0.75
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Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science (2004) 3.28
Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell (2004) 3.27
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Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat Cell Biol (2003) 3.04
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TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology (2002) 2.05
The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells. Mol Cell Biol (2001) 2.04
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Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Mol Cell (2003) 1.72
Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem (2004) 1.58
The COP9 signalosome: regulating plant development through the control of proteolysis. Annu Rev Plant Biol (2003) 1.53
CUL-4A is critical for early embryonic development. Mol Cell Biol (2002) 1.51
Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1. Biochem Biophys Res Commun (2001) 1.49
Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res (2004) 1.40
The p48 subunit of the damaged-DNA binding protein DDB associates with the CBP/p300 family of histone acetyltransferase. Mutat Res (2001) 1.29
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region. J Biol Chem (2003) 1.27
CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein. EMBO J (2003) 1.27
Ddb1 is required for the proteolysis of the Schizosaccharomyces pombe replication inhibitor Spd1 during S phase and after DNA damage. J Biol Chem (2003) 1.24
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CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome. Mol Biol Cell (2002) 1.11
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DDB2 induces nuclear accumulation of the hepatitis B virus X protein independently of binding to DDB1. J Virol (2001) 0.97
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Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev (2004) 3.91
FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J (2009) 2.11
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol (2006) 2.11
FoxM1 mediates resistance to herceptin and paclitaxel. Cancer Res (2010) 1.78
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FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem (2008) 1.58
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Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res (2004) 1.40
Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulator. J Virol (2004) 1.34
Telomeres avoid end detection by severing the checkpoint signal transduction pathway. Nature (2010) 1.33
The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. J Virol (2004) 1.25
The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1. Mol Cell Biol (2007) 1.25
FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. J Biol Chem (2007) 1.25
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Ddb1 is required for the proteolysis of the Schizosaccharomyces pombe replication inhibitor Spd1 during S phase and after DNA damage. J Biol Chem (2003) 1.24
Differential regulation of E2F1, DP1, and the E2F1/DP1 complex by ARF. Mol Cell Biol (2002) 1.23
DDB2 decides cell fate following DNA damage. Proc Natl Acad Sci U S A (2009) 1.22
Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment. PLoS Genet (2009) 1.20
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. J Biol Chem (2009) 1.17
FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors. Cancer Res (2011) 1.15
Tumor-prone phenotype of the DDB2-deficient mice. Oncogene (2005) 1.13
Cul4A is essential for spermatogenesis and male fertility. Dev Biol (2011) 1.11
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology (2010) 1.09
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FoxM1 regulates mammary luminal cell fate. Cell Rep (2012) 1.08
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Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression. J Biol Chem (2012) 1.03
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Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res (2009) 1.02
Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. J Biol Chem (2004) 1.01
Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation. Cancer Res (2007) 1.00
Study of C reactive protein as a prognostic marker in malaria from Eastern India. Adv Biomed Res (2012) 1.00
ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF. Mol Cell Biol (2005) 0.99
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Schizosaccharomyces pombe Ddb1 is functionally linked to the replication checkpoint pathway. J Biol Chem (2003) 0.95
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A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes. Exp Cell Res (2006) 0.90
p21 cooperates with DDB2 protein in suppression of ultraviolet ray-induced skin malignancies. J Biol Chem (2011) 0.90
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Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin. Cancer Biol Ther (2010) 0.88
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Targeting FoxM1 effectively retards p53-null lymphoma and sarcoma. Mol Cancer Ther (2013) 0.83
Hypoxia-induced pulmonary arterial smooth muscle cell proliferation is controlled by forkhead box M1. Am J Respir Cell Mol Biol (2011) 0.83
P19ARF inhibits the functions of the HPV16 E7 oncoprotein. Oncogene (2003) 0.83
HLA class II SNP interactions and the association with type 1 diabetes mellitus in Bengali speaking patients of Eastern India. J Biomed Sci (2013) 0.81
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Tumor regression by phenethyl isothiocyanate involves DDB2. Cancer Biol Ther (2012) 0.79
Cytoglobin in tumor hypoxia: novel insights into cancer suppression. Tumour Biol (2014) 0.78
Damaged DNA binding protein 2 in reactive oxygen species (ROS) regulation and premature senescence. Int J Mol Sci (2012) 0.78
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