Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

PubWeight™: 2.42‹?› | Rank: Top 2%

🔗 View Article (PMC 1880629)

Published in Am J Pathol on July 01, 1988

Authors

D W Dickson1, J Farlo, P Davies, H Crystal, P Fuld, S H Yen

Author Affiliations

1: Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY 10461.

Articles citing this

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci (2008) 3.90

CD36 mediates the innate host response to beta-amyloid. J Exp Med (2003) 2.65

Mechanisms of tau-induced neurodegeneration. Acta Neuropathol (2009) 2.27

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease. Am J Pathol (1990) 2.24

Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans. Acta Neuropathol (1994) 2.23

A review: inflammatory process in Alzheimer's disease, role of cytokines. ScientificWorldJournal (2012) 2.03

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol (1989) 1.95

Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. Proc Natl Acad Sci U S A (1999) 1.74

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol (1992) 1.71

Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci U S A (1991) 1.58

Neuropathology of Alzheimer's disease. Mt Sinai J Med (2010) 1.57

Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Acta Neuropathol (1989) 1.52

Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis. Proc Natl Acad Sci U S A (1999) 1.43

Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol (1990) 1.40

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques. Proc Natl Acad Sci U S A (1990) 1.31

Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta Neuropathol (1990) 1.28

Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. Am J Pathol (1989) 1.24

The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz) (2012) 1.23

Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention. J Cell Mol Med (2007) 1.21

APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Struct Funct (2009) 1.20

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease. Acta Neuropathol (1991) 1.20

Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. EMBO J (2007) 1.19

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques. Am J Pathol (1991) 1.19

About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation. Acta Neuropathol (1989) 1.18

Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease. J Cell Mol Med (2008) 1.16

Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance. Am J Pathol (2004) 1.11

Inflammatory process in Alzheimer's Disease. Front Integr Neurosci (2013) 1.10

Microglia in Alzheimer's disease and transgenic models. How close the fit? Am J Pathol (1999) 1.09

Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques. Am J Pathol (1996) 1.07

An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am J Pathol (1993) 1.06

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet (2008) 1.06

Innate immunity in Alzheimer's disease: a complex affair. CNS Neurol Disord Drug Targets (2013) 1.05

Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease. Neurobiol Aging (2007) 1.04

Monitoring pathological assembly of tau and beta-amyloid proteins in Alzheimer's disease. Acta Neuropathol (1995) 1.02

How to get from here to there: macrophage recruitment in Alzheimer's disease. Curr Alzheimer Res (2011) 1.02

Microglia in cerebellar plaques in Alzheimer's disease. Acta Neuropathol (1990) 1.02

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain (2016) 1.01

Increased senile plaques without microglia in Alzheimer's disease. Acta Neuropathol (1991) 1.00

Chaperone signalling complexes in Alzheimer's disease. J Cell Mol Med (2009) 0.99

Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci (2015) 0.96

Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target. J Biomed Biotechnol (2006) 0.96

Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Mol Med (2012) 0.96

Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease. J Neuropathol Exp Neurol (2012) 0.95

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy. Front Aging Neurosci (2014) 0.94

Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. Am J Pathol (2004) 0.94

Astrocytes and microglia in human brain share an epitope recognized by a B-lymphocyte-specific monoclonal antibody (LN-1). Am J Pathol (1989) 0.93

Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where. Future Neurol (2012) 0.93

Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease. Front Mol Neurosci (2009) 0.89

The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function. J Neurosci (2009) 0.89

Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease. J Nutr (2013) 0.87

Developing pharmacological therapies for Alzheimer disease. Cell Mol Life Sci (2007) 0.87

Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease. Am J Pathol (1994) 0.87

Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice. Front Cell Neurosci (2012) 0.87

Microglia in Alzheimer brain: a neuropathological perspective. Int J Alzheimers Dis (2012) 0.87

Neuroprotective roles of the P2Y(2) receptor. Purinergic Signal (2012) 0.84

White matter amyloid in Alzheimer's disease brain. Acta Neuropathol (1995) 0.84

Pathways towards an effective immunotherapy for Parkinson's disease. Expert Rev Neurother (2011) 0.84

Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plast (2014) 0.84

Meningioangiomatosis: an immunocytochemical study. Acta Neuropathol (1991) 0.83

³H-deprenyl and ³H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain. J Neuroinflammation (2013) 0.83

A lysosomal marker for activated microglial cells involved in Alzheimer classic senile plaques. Acta Neuropathol (1995) 0.83

Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's disease. Acta Neuropathol (2009) 0.82

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial. Biochem Soc Trans (2010) 0.82

Distribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer's disease and non-demented elderly. Acta Neuropathol (1995) 0.82

Latest Study on the Relationship between Pathological Process of Inflammatory Injury and the Syndrome of Spleen Deficiency and Fluid Retention in Alzheimer's Disease. Evid Based Complement Alternat Med (2014) 0.82

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease. Neurobiol Aging (2015) 0.82

Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. Am J Pathol (2004) 0.80

Fibrillar amyloid plaque formation precedes microglial activation. PLoS One (2015) 0.80

Young microglia restore amyloid plaque clearance of aged microglia. EMBO J (2016) 0.80

Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus. Acta Neuropathol (1994) 0.79

Alzheimer neuropathology in non-Down's syndrome mentally retarded adults. Acta Neuropathol (1990) 0.78

Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease. Mediators Inflamm (2013) 0.78

A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. J Aging Res (2011) 0.77

Neuroinflammation and copper in Alzheimer's disease. Int J Alzheimers Dis (2013) 0.77

Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. J Neuroinflammation (2015) 0.75

Defining the earliest pathological changes of Alzheimer's disease. Curr Alzheimer Res (2016) 0.75

Regional correlations between [(11)C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort. Neuroimage Clin (2016) 0.75

Neuroprotective effects of geniposide in SH-SY5Y cells and primary hippocampal neurons exposed to Aβ42. Biomed Res Int (2014) 0.75

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice. Acta Neuropathol Commun (2015) 0.75

Alzheimer's disease--neuropathological aspects. Can J Vet Res (1990) 0.75

Articles cited by this

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13

Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). N Engl J Med (1980) 9.38

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science (1987) 6.89

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A (1986) 6.56

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA. Am J Pathol (1964) 4.39

Observations on the brains of non-demented old people. J Neurol Sci (1969) 4.06

ALZHEIMER'S DISEASE--AN ELECTRON MICROSCOPICAL STUDY. Brain (1964) 3.82

The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science (1987) 3.59

A neuronal antigen in the brains of Alzheimer patients. Science (1986) 3.49

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J Neurosci (1987) 3.39

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett (1986) 3.36

Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science (1987) 3.23

Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease. Science (1987) 3.07

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci (1985) 2.72

The AMeX method. A simplified technique of tissue processing and paraffin embedding with improved preservation of antigens for immunostaining. Am J Pathol (1986) 2.19

The contribution of altered synapses in the senile plaque: an electron microscopic study in Alzheimer's dementia. J Neuropathol Exp Neurol (1967) 2.18

Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease. Neurosci Lett (1986) 2.01

A specific histochemical marker (lectin Ricinus communis agglutinin-1) for normal human microglia, and application to routine histopathology. Acta Neuropathol (1986) 1.98

Lectin binding by resting and reactive microglia. J Neurocytol (1987) 1.96

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A (1987) 1.96

Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study. Lab Invest (1970) 1.93

Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol (1973) 1.85

Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides. Am J Pathol (1985) 1.84

Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles. J Neuropathol Exp Neurol (1987) 1.78

Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am J Pathol (1985) 1.77

Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer's disease and senile dementia of Alzheimer type. Ann Neurol (1985) 1.75

A special type of senile plaque, possibly an initial stage. Acta Neuropathol (1987) 1.73

Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2. Am J Pathol (1987) 1.66

Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon. Acta Neuropathol (1984) 1.60

Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent. Ann Neurol (1981) 1.56

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease. Proc Natl Acad Sci U S A (1987) 1.56

Form and distribution of senile plaques seen in silver impregnated sections in the brains of intellectually normal elderly people and people with Alzheimer-type dementia. Neuropathol Appl Neurobiol (1984) 1.53

Alz-50 antibody recognizes Alzheimer-related neuronal changes. Ann Neurol (1988) 1.39

Fibrous Astrocytes in senile dementia of the Alzheimer type. J Neuropathol Exp Neurol (1981) 1.23

Multinucleated giant cells in acquired immunodeficiency syndrome encephalopathy. Origin from endogenous microglia? Arch Pathol Lab Med (1986) 1.17

Recognizing neurotoxic disease. Neurology (1987) 1.14

Sulfated glycosaminoglycans in Alzheimer's disease. Hum Pathol (1987) 1.09

Two monoclonal antibodies recognize Alzheimer's neurofibrillary tangles, neurofilament, and microtubule-associated proteins. J Neurochem (1987) 1.07

Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease. Acta Neuropathol (1986) 0.95

Morphogenesis of amyloid plaques in mice with Creutzfeldt-Jakob disease. Acta Neuropathol (1985) 0.92

Amyloid scrapie plaques in mice, and Alzheimer senile plaques, share common antigens with tau, a microtubule-associated protein. Neurosci Lett (1987) 0.89

Age incidence of senile brain amyloidosis. Pathol Res Pract (1986) 0.85

The hippocampus: organizational patterns in health and senescence. Mech Ageing Dev (1979) 0.85

Synaptic atrophy in the senescent hippocampus. Mech Ageing Dev (1979) 0.84

Primitive plaques and memory dysfunction in normal and impaired elderly persons. N Engl J Med (1987) 0.82

Relationship between numbers of cortical argentophilic and congophilic senile plaques in the brains of elderly people with and without senile dementia of Alzheimer type. Gerontology (1985) 0.80

Articles by these authors

The genome sequence of Drosophila melanogaster. Science (2000) 74.32

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature (1998) 15.24

Validation of a short Orientation-Memory-Concentration Test of cognitive impairment. Am J Psychiatry (1983) 8.71

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA (2000) 6.55

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet (2000) 6.12

Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet (1976) 6.09

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science (2001) 6.00

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nat Genet (1993) 5.70

Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol (1988) 5.18

Role of contractile microfilaments in macrophage movement and endocytosis. Nat New Biol (1971) 4.82

Macrophages synthesis and release prostaglandins in response to inflammatory stimuli. Nature (1977) 4.75

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci U S A (1990) 4.26

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature (1999) 3.96

Screening for dementia by memory testing. Neurology (1988) 3.93

Intermediate filaments in nervous tissues. J Cell Biol (1978) 3.51

Regional organisation of neonatal intensive care in the North-west. Br Med J (1979) 3.50

A neuronal antigen in the brains of Alzheimer patients. Science (1986) 3.49

Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology (1988) 3.40

Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging (1992) 3.05

Biochemistry of the filaments of brain. Proc Natl Acad Sci U S A (1976) 3.03

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging (2005) 3.00

Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes. Nature (1974) 2.86

Regulation of prostaglandin synthesis and of the selective release of lysosomal hydrolases by mouse peritoneal macrophages. Biochem J (1978) 2.77

Changes in cellular enzyme levels and extracellular release of lysosomal acid hydrolases in macrophages exposed to group A streptococcal cell wall substance. J Exp Med (1974) 2.72

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J Neurosci Res (1997) 2.71

Lewy bodies of Parkinson's disease contain neurofilament antigens. Science (1983) 2.70

Memory impairment on free and cued selective reminding predicts dementia. Neurology (2000) 2.58

Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann Neurol (1994) 2.54

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia (1993) 2.51

Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy. J Clin Oncol (1995) 2.50

Development of dementing illnesses in an 80-year-old volunteer cohort. Ann Neurol (1989) 2.49

Dapsone in rheumatoid arthritis. Rheumatol Rehabil (1976) 2.45

Antibodies to neurofilament, glial filament, and fibroblast intermediate filament proteins bind to different cell types of the nervous system. J Cell Biol (1981) 2.41

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem (1992) 2.40

Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging (2000) 2.40

The relative frequency of "dementia of unknown etiology" increases with age and is nearly 50% in nonagenarians. Arch Neurol (2000) 2.35

A systematic review of the role of human papillomavirus testing within a cervical screening programme. Health Technol Assess (1999) 2.32

Effects of gold, dapsone, and prednisone on serum C-reactive protein and haptoglobin and the erythrocyte sedimentation rate in rheumatoid arthritis. Ann Rheum Dis (1979) 2.30

Relation between initial blood pressure and its fall with treatment. Lancet (1985) 2.27

The role of arachidonic acid oxygenation products in pain and inflammation. Annu Rev Immunol (1984) 2.25

The Campbell Collaboration. Does for public policy what cochrane does for health. BMJ (2001) 2.24

The power of the classical twin study. Heredity (Edinb) (1978) 2.23

Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans. Acta Neuropathol (1994) 2.23

Communication disorders: planning a service to meet the needs. Br J Disord Commun (1989) 2.22

How does functional disability in early rheumatoid arthritis (RA) affect patients and their lives? Results of 5 years of follow-up in 732 patients from the Early RA Study (ERAS) Rheumatology (Oxford) (2000) 2.21

A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. N Engl J Med (1987) 2.21

Why don't patients turn up? Health Soc Serv J (1984) 2.20

Relationship between production and release of lymphocyte-activating factor (interleukin 1) by murine macrophages. 1. Effects of various agents. Cell Immunol (1981) 2.18

Memory and mental status correlates of modified Braak staging. Neurobiol Aging (2000) 2.15

Which patients stop working because of rheumatoid arthritis? Results of five years' follow up in 732 patients from the Early RA Study (ERAS). Ann Rheum Dis (2002) 2.11

Neurotransmitter-related enzymes in senile dementia of the Alzheimer type. Brain Res (1979) 2.04

The biological effects of magnesium-leached chrysotile asbestos. Br J Exp Pathol (1977) 2.03

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa. Nature (1980) 2.02

Immunocytochemical studies of neurofibrillary tangles. Am J Pathol (1981) 2.01

Mitotic mechanisms in Alzheimer's disease? J Cell Biol (1996) 2.00

A nucleated assembly mechanism of Alzheimer paired helical filaments. Proc Natl Acad Sci U S A (1998) 1.97

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A (1987) 1.96

Antigen-antibody complexes stimulate the synthesis and release of prostaglandins by mouse peritoneal macrophages. Prostaglandins (1979) 1.95

Women, myocardial infarction, and dementia in the very old. Neurology (1990) 1.94

Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class. Am J Pathol (1983) 1.93

A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. Eur J Neurol (2011) 1.93

Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients. Br J Cancer (2003) 1.90

Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging (1995) 1.90

Risking everything? Risk behavior, behavior change, and AIDS. Science (1994) 1.89

The inhibition of phagocytosis and facilitation of exocytosis in rabbit polymorphonuclear leukocytes by cytochalasin B. Lab Invest (1973) 1.89

The pulmonary vascular lesions of the adult respiratory distress syndrome. Am J Pathol (1983) 1.88

Ability of activated complement components to induce lysosomal enzyme release from macrophages. Nature (1976) 1.85

Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis (2000) 1.84

Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides. Am J Pathol (1985) 1.84

Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p. Acta Neuropathol (2000) 1.79

Resting metabolic rate in homozygous sickle cell disease. Am J Clin Nutr (1993) 1.79

Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles. J Neuropathol Exp Neurol (1987) 1.78

Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am J Pathol (1985) 1.77

Significance of the individual components of the Apgar score. Br J Anaesth (1973) 1.76

Acute reactions to urographic contrast media. Br Med J (1975) 1.71

Mechanisms of endocytosis and exocytosis. Symp Soc Exp Biol (1974) 1.69

Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology (1991) 1.69

Chlamydia pneumoniae and asthma. Thorax (1998) 1.67

Paracetamol induced hepatotoxicity. Arch Dis Child (2006) 1.67

Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2. Am J Pathol (1987) 1.66

Widespread alterations of alpha-synuclein in multiple system atrophy. Am J Pathol (1999) 1.65

Is rheumatoid arthritis becoming less severe? J Chronic Dis (1983) 1.64

Connectivity of an effective hypothalamic surgical target for cluster headache. J Clin Neurosci (2007) 1.64

Immune complexes induce selective release of lysosomal hydrolases from macrophages. Nature (1974) 1.64

The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating. FEBS Lett (1997) 1.64

cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease. J Neurosci (1999) 1.63

The diminished production of arachidonic acid oxygenation products by elicited mouse peritoneal macrophages: possible mechanisms. J Immunol (1980) 1.63

Alz 50, a monoclonal antibody to Alzheimer's disease antigen, cross-reacts with tau proteins from bovine and normal human brain. J Biol Chem (1988) 1.61

Purification and properties of filamin, and actin binding protein from chicken gizzard. J Biol Chem (1976) 1.60

Pathogenesis of the chronic inflammatory lesion induced by group A streptococcal cell walls. Lab Invest (1974) 1.60

Participation of mononuclear phagocytes in chronic inflammatory diseases. J Reticuloendothel Soc (1974) 1.59

CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology (2002) 1.58