Published in EMBO J on December 21, 2016
Reestablishing microglia function: good news for Alzheimer's therapy? EMBO J (2017) 0.75
Aging Microglia-Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases. Front Aging Neurosci (2017) 0.75
Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies. Front Aging Neurosci (2017) 0.75
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69
The Ki-67 protein: from the known and the unknown. J Cell Physiol (2000) 16.48
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol (2000) 14.74
A simple method for organotypic cultures of nervous tissue. J Neurosci Methods (1991) 14.18
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature (1999) 12.95
Microglia: a sensor for pathological events in the CNS. Trends Neurosci (1996) 12.00
TREM2 variants in Alzheimer's disease. N Engl J Med (2012) 11.35
Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci (2007) 11.11
Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med (2000) 8.89
Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science (2010) 8.04
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med (2001) 7.85
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med (2003) 7.83
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature (2008) 6.89
The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature (2011) 6.71
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron (2006) 6.38
Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med (2006) 6.15
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med (2007) 5.87
Alzheimer's disease: the challenge of the second century. Sci Transl Med (2011) 4.88
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science (1994) 4.81
Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature (1995) 4.18
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med (2011) 4.07
Risk of Alzheimer's disease and duration of NSAID use. Neurology (1997) 4.06
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep (2006) 4.06
Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci (2013) 3.94
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci (2008) 3.90
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci U S A (2009) 3.86
Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med (2014) 3.75
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol (1989) 3.58
Regeneration of a germinal layer in the adult mammalian brain. Proc Natl Acad Sci U S A (1999) 3.53
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron (2013) 3.43
Action of cytochalasin D on cytoskeletal networks. J Cell Biol (1982) 3.39
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest (2008) 3.36
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15
GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity (2001) 3.13
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature (2016) 3.06
Neuroinflammation in Alzheimer's disease. Lancet Neurol (2015) 3.02
Probing the biology of Alzheimer's disease in mice. Neuron (2010) 2.96
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci (2009) 2.85
Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol (1998) 2.85
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med (2001) 2.75
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J Neurosci (2008) 2.57
Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. Am J Pathol (1988) 2.42
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. J Neurosci (2004) 2.38
Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain (2010) 2.33
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain (2005) 2.27
Abeta species removal after abeta42 immunization. J Neuropathol Exp Neurol (2006) 2.25
The role of microglia in amyloid clearance from the AD brain. J Neural Transm (Vienna) (2010) 2.21
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci (2009) 2.20
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell (2015) 2.15
Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology (2002) 2.12
Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am J Pathol (1999) 2.10
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med (2014) 2.05
Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J Neuropathol Exp Neurol (2005) 1.90
Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis (2005) 1.88
CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. J Neurosci (2010) 1.88
Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain (2009) 1.84
Dystrophic microglia in the aging human brain. Glia (2004) 1.79
Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia (2002) 1.79
Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol (1992) 1.71
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology. Brain (2016) 1.69
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature (2015) 1.62
Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Mol Biol Cell (2007) 1.61
Regulation of microglial proliferation during chronic neurodegeneration. J Neurosci (2013) 1.59
Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J Neurosci (1996) 1.59
IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior. Neuron (2015) 1.58
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging (2004) 1.56
Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol (1989) 1.54
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia (2001) 1.53
Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci (1999) 1.52
Immunotherapeutic approaches to Alzheimer's disease. Science (2003) 1.52
Microglial dysfunction in brain aging and Alzheimer's disease. Biochem Pharmacol (2014) 1.52
Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology. Neuron (2015) 1.49
Neuroprotective function for ramified microglia in hippocampal excitotoxicity. J Neuroinflammation (2012) 1.49
Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS One (2013) 1.48
Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. J Biol Chem (1997) 1.45
Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. J Biol Chem (1999) 1.42
Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro. J Immunol (1993) 1.36
Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study. Neurology (2000) 1.33
The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol (1990) 1.31
Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiol Dis (2007) 1.25
Microglia actively regulate the number of functional synapses. PLoS One (2013) 1.25
Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience (2009) 1.22
A new method to isolate microglia from adult mice and culture them for an extended period of time. J Neurosci Methods (2010) 1.22
GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice. J Alzheimers Dis (2010) 1.22
Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. J Exp Med (2015) 1.20
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med (2015) 1.19
Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp Neurol (2000) 1.19
Microglia function in Alzheimer's disease. Front Pharmacol (2012) 1.17
The role of the immune system in clearance of Abeta from the brain. Brain Pathol (2008) 1.14
Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J Neurosci Res (1996) 1.14
Immunotherapeutic approaches for Alzheimer's disease. Neuron (2015) 1.13
Microglial pathology. Acta Neuropathol Commun (2014) 1.13
Long-term in vivo imaging of β-amyloid plaque appearance and growth in a mouse model of cerebral β-amyloidosis. J Neurosci (2011) 1.11
Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiol Aging (2014) 1.11
GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia (1994) 1.10
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J (2017) 0.77
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO Rep (2017) 0.75
Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins. EMBO Mol Med (2017) 0.75
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med (2017) 0.75