Published in Biochem J on April 15, 1988
How neutrophils kill microbes. Annu Rev Immunol (2005) 6.87
The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems. Biochim Biophys Acta (2004) 2.39
Temperature dependence of voltage-gated H+ currents in human neutrophils, rat alveolar epithelial cells, and mammalian phagocytes. J Gen Physiol (1998) 2.09
Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol (2011) 1.97
Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils. Biophys J (1993) 1.91
Retracted The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature (2004) 1.85
Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge. Biochem J (1988) 1.83
Hydrogen ion currents in rat alveolar epithelial cells. Biophys J (1991) 1.71
The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels. J Gen Physiol (2006) 1.48
Interactions between NADPH oxidase-related proton and electron currents in human eosinophils. J Physiol (2001) 1.46
Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions. PLoS One (2015) 1.41
Evidence that the product of the human X-linked CGD gene, gp91-phox, is a voltage-gated H(+) pathway. J Gen Physiol (1999) 1.38
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
Phorbol 12-myristate 13-acetate activates an electrogenic H(+)-conducting pathway in the membrane of neutrophils. Biochem J (1992) 1.30
The NADPH-oxidase-associated H+ channel is opened by arachidonate. Biochem J (1992) 1.27
Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid. J Physiol (2001) 1.24
Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. Physiology (Bethesda) (2010) 1.22
The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox. Biochem J (1997) 1.21
Voltage-gated proton channels: what's next? J Physiol (2008) 1.21
Intracellular pH regulation during spreading of human neutrophils. J Cell Biol (1996) 1.19
Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol (2008) 1.15
Voltage-activated proton current in eosinophils from human blood. J Physiol (1996) 1.15
The gp91phox component of NADPH oxidase is not a voltage-gated proton channel. J Gen Physiol (2002) 1.14
Voltage-activated proton currents in human lymphocytes. J Physiol (2002) 1.10
Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis. J Neurosci (2010) 1.06
pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1. Trends Cell Biol (2010) 1.01
A highly temperature-sensitive proton current in mouse bone marrow-derived mast cells. J Gen Physiol (1997) 1.01
Cartilage degradation by polymorphonuclear leucocytes: in vitro assessment of the pathogenic mechanisms. Ann Rheum Dis (1993) 1.00
Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains. J Neurochem (2011) 0.99
Electron and proton transport by NADPH oxidases. Philos Trans R Soc Lond B Biol Sci (2005) 0.97
Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? Prog Neurobiol (2014) 0.96
Interactions between electron and proton currents in excised patches from human eosinophils. J Gen Physiol (2003) 0.94
Philosophy of voltage-gated proton channels. J R Soc Interface (2013) 0.90
Inhibition of the neutrophil NADPH oxidase and associated H+ channel by diethyl pyrocarbonate (DEPC), a histidine-modifying agent: evidence for at least two target sites. Biochem J (2001) 0.90
Cyclosporin A inhibits phorbol ester-induced activation of superoxide production in resident mouse peritoneal macrophages. Biochem J (1989) 0.90
Gene expression analysis implicates a death receptor pathway in schizophrenia pathology. PLoS One (2012) 0.88
Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2. Biochem J (1997) 0.88
Regulation of the electrogenic H+ channel in the plasma membrane of neutrophils: possible role of phospholipase A2, internal and external protons. Biochem J (1993) 0.86
Voltage-gated proton channels. Compr Physiol (2012) 0.85
Strong glucose dependence of electron current in human monocytes. Am J Physiol Cell Physiol (2011) 0.85
Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology. Antioxid Redox Signal (2014) 0.83
Lymphocytes possess an electrogenic H(+)-transporting pathway in their plasma membrane. Biochem J (1994) 0.83
The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma. Biochemistry (2015) 0.83
NADPH oxidase subunit gp91phox: a proton pathway. Protoplasma (2001) 0.82
The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino-acid fragment of gp91phox. Biochem J (2003) 0.82
Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity. PLoS One (2015) 0.80
Docosahexaenoic acid and other fatty acids induce a decrease in pHi in Jurkat T-cells. Br J Pharmacol (2003) 0.79
Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia. J Physiol (2011) 0.78
Consequences of dimerization of the voltage-gated proton channel. Prog Mol Biol Transl Sci (2013) 0.78
Phosphoinositide 3-kinase-dependent regulation of Na+/H+ exchanger in dendritic cells. Pflugers Arch (2010) 0.78
Activation of multiple pH-regulatory pathways in granulocytes by a phosphotyrosine phosphatase antagonist. Biochem J (1994) 0.77
Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel. Proc Natl Acad Sci U S A (2016) 0.76
Proton channels in non-phagocytic cells of the immune system. Wiley Interdiscip Rev Membr Transp Signal (2013) 0.75
Purification and characterization of a plasma membrane ferricyanide-utilizing NADH dehydrogenase from Ehrlich tumour cells. Biochem J (1996) 0.75
Regulation of Na+/H+ exchanger in dendritic cells by Akt2. Pflugers Arch (2011) 0.75
The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase. Immunol Rev (2016) 0.75
Molecular Profiling of Multiplexed Gene Markers to Assess Viability of Ex Vivo Human Colon Explant Cultures. Biores Open Access (2015) 0.75
Proton conductance and intracellular pH recovery from an acid load in chicken enterocytes. J Physiol (1995) 0.75
Extracellular phosphates enhance activities of voltage-gated proton channels and production of reactive oxygen species in murine osteoclast-like cells. Pflugers Arch (2016) 0.75
Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med (1978) 11.45
Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry (1979) 11.28
Cytoplasmic pH and free Mg2+ in lymphocytes. J Cell Biol (1982) 5.30
The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J (1986) 4.35
The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature (1981) 4.01
The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability. Biochem J (1969) 3.58
The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J (1987) 3.19
Measurement of intralysosomal pH. Biochim Biophys Acta (1973) 2.59
The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex. Nature (1987) 2.38
Functional activity of enucleated human polymorphonuclear leukocytes. J Cell Biol (1983) 2.32
The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245. Nature (1987) 2.14
Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease. FEBS Lett (1980) 2.09
Chronic granulomatous disease: a syndrome of phagocyte oxidase deficiencies. Medicine (Baltimore) (1983) 2.01
Phagolysosomal pH of human neutrophils. Blood (1984) 1.75
Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH. Biochem J (1985) 1.73
Cytoplasmic pH regulation in phorbol ester-activated human neutrophils. Am J Physiol (1986) 1.68
Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease. Lancet (1978) 1.45
Chemotactic factor-induced activation of Na+/H+ exchange in human neutrophils. II. Intracellular pH changes. J Biol Chem (1985) 1.33
Regulation of the mitochondrial matrix volume in vivo and in vitro. The role of calcium. Biochem J (1986) 1.29
Specific modulation of the intracellular pH of rabbit neutrophils by chemotactic factors. Biochem Biophys Res Commun (1980) 1.24
Cytoplasmic pH regulation in normal and abnormal neutrophils. Role of superoxide generation and Na+/H+ exchange. J Biol Chem (1986) 1.23
Properties and reconstitution of a cytochrome oxidase deficient in subunit III. Eur J Biochem (1983) 1.01
Phorbol ester-induced changes of cytoplasmic pH in neutrophils: role of exocytosis in Na+-H+ exchange. Am J Physiol (1985) 0.90
Osmotic activation of the Na+/H+ antiport in protein kinase C-depleted lymphocytes. Biochem Biophys Res Commun (1986) 0.89
Intracellular pH changes during neutrophil activation: Na+/H+ antiport. J Leukoc Biol (1987) 0.88
A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity. Biochem J (1964) 41.13
The oxidation of citrate, isocitrate and cis-aconitate by isolated mitochondria. Biochem J (1964) 6.08
Systems used for the transport of substrates into mitochondria. Br Med Bull (1968) 5.21
The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J (1986) 4.35
The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability. Biochem J (1969) 3.58
The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J (1987) 3.19
Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem J (1993) 3.12
Absence of cytochrome b-245 in chronic granulomatous disease. A multicenter European evaluation of its incidence and relevance. N Engl J Med (1983) 2.89
The structural organization of haem synthesis in rat liver mitochondria. Biochem J (1969) 2.74
The enzymic reduction and kinetics of oxidation of cytochrome b-245 of neutrophils. Biochem J (1982) 2.68
The inhibition of malate, tricarboxylate and oxoglutarate entry into mitochondria by 2-n-butylmalonate. Biochem Biophys Res Commun (1967) 2.64
Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst. Biochem J (1981) 2.56
Protoheme turnover and chlorophyll synthesis in greening barley tissue. Plant Physiol (1975) 2.56
The effect of Ca2+ on the oxidation of glycerol phosphate by blowfly flight-muscle mitochondria. Biochem Biophys Res Commun (1967) 2.55
Enzymic mechanisms of superoxide production. Biochim Biophys Acta (1991) 2.26
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages. Biochem J (1987) 2.18
Novel cytochrome b system in phagocytic vacuoles of human granulocytes. Nature (1978) 2.15
Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease. FEBS Lett (1980) 2.09
Penetration of the mitochondrial membrane by glutamate and aspartate. Biochem Biophys Res Commun (1967) 1.99
Penetration of the mitochondrial membrane by tricarboxylic acid anions. Biochem Soc Symp (1968) 1.91
The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils. Biochem J (1979) 1.87
Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge. Biochem J (1988) 1.83
The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations. Biochem J (1984) 1.80
Expression of phagocyte NADPH oxidase components in human endothelial cells. Am J Physiol (1996) 1.75
Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH. Biochem J (1985) 1.73
Ferrochelatase of spinach chloroplasts. Biochem J (1968) 1.73
Dihydrorhodamine 123: a fluorescent probe for superoxide generation? Eur J Biochem (1993) 1.65
The effects of 2,4-dinitrophenol on mitochondrial oxidations. Biochem J (1964) 1.61
Cytochrome b-245 of neutrophils is also present in human monocytes, macrophages and eosinophils. Biochem J (1981) 1.61
Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body. Biochem J (1990) 1.60
The arachidonate-activable, NADPH oxidase-associated H+ channel. Evidence that gp91-phox functions as an essential part of the channel. J Biol Chem (1995) 1.53
Energy-linked electron transfer reactions in Rhodopseudomonas viridis. Biochim Biophys Acta (1972) 1.52
Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate. Biochem Biophys Res Commun (1979) 1.50
Ferrochelatase of Rhodopseudomonas spheroides. Biochem J (1970) 1.50
Transport of glutamine and glutamate in kidney mitochondria in relation to glutamine deamidation. Biochem J (1973) 1.49
The effect of the NADPH oxidase inhibitor diphenyleneiodonium on aerobic and anaerobic microbicidal activities of human neutrophils. Biochem J (1988) 1.49
Limited-turnover studies on proton translocation in reconstituted cytochrome c oxidase-containing vesicles. Biochem J (1979) 1.48
The association of FAD with the cytochrome b-245 of human neutrophils. Biochem J (1982) 1.45
Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease. Lancet (1978) 1.45
Functional expression of NADPH oxidase components (alpha- and beta-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells. J Biol Chem (1991) 1.38
Effect of L-leucine on the nitrogen metabolism of isolated rat liver mitochondria. Biochem J (1973) 1.34
Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem J (1991) 1.34
Involvement of phenyl radicals in iodonium inhibition of flavoenzymes. Mol Pharmacol (1994) 1.30
The NADPH-oxidase-associated H+ channel is opened by arachidonate. Biochem J (1992) 1.27
Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines. J Immunol (1989) 1.27
Internalization of the Kv1.4 potassium channel is suppressed by clustering interactions with PSD-95. J Biol Chem (2000) 1.27
The cytochromes in microsomal fractions of germinating mung beans. Biochem J (1981) 1.26
The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig. J Immunol (1988) 1.26
Studies on the electron-transfer mechanism of the human neutrophil NADPH oxidase. Biochem J (1989) 1.23
Adaptive changes in the capacity of systems used for the synthesis of citrulline in rat liver mitochondria in response to high- and-low-protein diets. Biochem J (1974) 1.22
The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox. Biochem J (1997) 1.21
Distribution of Ca2+ channels on frog motor nerve terminals revealed by fluorescent omega-conotoxin. J Neurosci (1991) 1.19
Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase. Biochem J (1989) 1.19
The subcellular loclization and properties of the ferrochelatase of etiolated barley. Biochem J (1976) 1.19
Annular and non-annular binding sites on the (Ca2+ + Mg2+)-ATPase. Biochim Biophys Acta (1982) 1.18
The transport of inorganic phosphate by the mitochondrial dicarboxylate carrier. Biochem J (1973) 1.17
Rapid incorporation of the human neutrophil plasma membrane cytochrome b into phagocytic vacuoles. Biochem Biophys Res Commun (1980) 1.13
Fluorocitrate inhibition of aconitate hydratase and the tricarboxylate carrier of rat liver mitochondria. Biochem J (1973) 1.13
The expression of NADPH oxidase components in human glomerular mesangial cells: detection of protein and mRNA for p47phox, p67phox, and p22phox. J Am Soc Nephrol (1995) 1.13
Magnesium 2,4-divinylphaeoporphyrin alpha-5 as a substrate for chlorophyll biosynthesis in vitro. FEBS Lett (1975) 1.09
Properties of substituted 2-trifluoromethylbenzimidazoles as uncouplers of oxidative phosphorylation. Biochem J (1967) 1.09
A quantitative characterisation of H+ translocation by cytochrome c oxidase vesicles. Biochim Biophys Acta (1984) 1.09
The use of N-methylprotoporphyrin dimethyl ester to inhibit ferrochelatase in Rhodopseudomonas sphaeroides and its effect in promoting biosynthesis of magnesium tetrapyrroles. Biochem J (1982) 1.09
The effects L-leucine on the synthesis of urea, glutamate and glutamine by isolated rat liver cells. Biochem J (1975) 1.09
Development of cytochrome b and an active oxidase system in association with maturation of a human promyelocytic (HL-60) cell line. J Cell Biol (1982) 1.08
Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle. J Physiol (1997) 1.08
Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation. Eur J Neurosci (2000) 1.08
The use of continuous assays to characterize the oxidative cyclase that synthesizes the chlorophyll isocyclic ring. Biochem J (1987) 1.08
The utilization of iron and its complexes by mammalian mitochondria. Biochem J (1972) 1.08
N-type Ca2+ channels are located on somata, dendrites, and a subpopulation of dendritic spines on live hippocampal pyramidal neurons. J Neurosci (1994) 1.07
Conditions for activity of glutaminase in kidney mitochondria. Biochem J (1970) 1.07
The energy-dependent accumulation of phosphate by blowfly mitochondria and its effect on the rate of pyruvate oxidation. Biochem Biophys Res Commun (1968) 1.06
Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate. Epilepsia (2000) 1.05
The functional expression of p47-phox and p67-phox may contribute to the generation of superoxide by an NADPH oxidase-like system in human fibroblasts. FEBS Lett (1994) 1.04
A novel use for a carbodiimide compound for the fixation of fluorescent and non-fluorescent calcium indicators in situ following physiological experiments. Cell Calcium (1997) 1.04
Changes in the cytochrome composition of Rhodopseudomonas sphaeroides grown aerobically, photosynthetically and on dimethyl sulphoxide. Biochem J (1983) 1.03
Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2). Biochem J (1993) 1.03
The use of diphenylene iodonium, an inhibitor of NADPH oxidase, to investigate the antimicrobial action of human monocyte derived macrophages. J Immunol Methods (1990) 1.03
Cytochrome c2--an electron carrier shared by the respiratory and photosynthetic electron transport chain of Rhodopseudomonas capsulata. FEBS Lett (1978) 1.02
The intramitochondrial location of the glutaminase isoenzymes of pig kidney. Biochem J (1973) 1.02
Kinetic and thermodynamic properties of membrane-bound cytochromes of aerobically and photosynthetically grown Rhodopseudomonas spheroides. Biochim Biophys Acta (1973) 1.01
Biogenesis of mitochondria. The effects of altered membrane lipid composition on cation transport by mitochondria of Saccharomyces cerevisiae. Biochem J (1973) 1.01
The subcellular localization of ubiquinone in human neutrophils. Biochem J (1983) 1.00
The cytochrome b and flavin content and properties of the O2- -forming NADPH oxidase solubilized from activated neutrophils. Biochim Biophys Acta (1983) 1.00
Haem synthesis during cytochrome P-450 induction in higher plants. 5-Aminolaevulinic acid synthesis through a five-carbon pathway in Helianthus tuberosus tuber tissues aged in the dark. Biochem J (1988) 1.00
Abnormal axonal physiology is associated with altered expression and distribution of Kv1.1 and Kv1.2 K+ channels after chronic spinal cord injury. Eur J Neurosci (2000) 1.00
Studies on the structure of a pigment related to chlorophyll a produced by Rhodopseudomonas spheroides. Biochem J (1964) 0.99
A variant form of X-linked chronic granulomatous disease with normal nitroblue tetrazolium slide test and cytochrome b. Eur J Clin Invest (1983) 0.99
On the metabolic function of glutamate dehydrogenase in rat liver. FEBS Lett (1975) 0.98
Induction of synthesis of components of the hydrogen peroxide-generating oxidase during activation of the human monocytic cell line U937 by interferon-gamma. Biochem J (1987) 0.98
Impact of cytoplasmic calcium buffering on the spatial and temporal characteristics of intercellular calcium signals in astrocytes. J Neurosci (1997) 0.97
Oxidative phosphorylation and effects of aerobic conditions on Rhodopseudomonas viridis. Biochim Biophys Acta (1973) 0.97
Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat Kv4.2 potassium channel gene. Neurosci Lett (1997) 0.97
Fluorescence yield properties of a fraction enriched in newly synthesized bacteriochlorophyll a-protein complexes from rhodopseudomonas sphaeroides. Photochem Photobiol (1979) 0.97