Published in J Biol Chem on February 28, 2014
Na+ interactions with the neutral amino acid transporter ASCT1. J Biol Chem (2014) 0.95
The domain interface of the human glutamate transporter EAAT1 mediates chloride permeation. Biophys J (2014) 0.90
Molecular physiology of EAAT anion channels. Pflugers Arch (2015) 0.80
Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking. J Biol Chem (2016) 0.80
Conformationally sensitive proximity of extracellular loops 2 and 4 of the γ-aminobutyric acid (GABA) transporter GAT-1 inferred from paired cysteine mutagenesis. J Biol Chem (2014) 0.77
The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2. J Biol Chem (2015) 0.77
Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1. J Biol Chem (2016) 0.76
The importance of the excitatory amino acid transporter 3 (EAAT3). Neurochem Int (2016) 0.75
Transport and channel functions in EAATs: the missing link. Channels (Austin) (2015) 0.75
Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters. Elife (2017) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci U S A (1986) 32.58
Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature (2004) 6.02
Flux coupling in a neuronal glutamate transporter. Nature (1996) 4.43
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature (2007) 4.14
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature (1995) 4.14
Ion fluxes associated with excitatory amino acid transport. Neuron (1995) 3.76
Primary structure and functional characterization of a high-affinity glutamate transporter. Nature (1992) 3.69
Transport mechanism of a bacterial homologue of glutamate transporters. Nature (2009) 3.12
Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci U S A (1997) 2.86
Structural aspects of metal liganding to functional groups in proteins. Adv Protein Chem (1991) 2.57
Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake. J Neurosci (1998) 2.50
The uncoupled chloride conductance of a bacterial glutamate transporter homolog. Nat Struct Mol Biol (2007) 2.49
Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J Neurosci (1998) 2.48
Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature (1987) 2.18
Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds. Proc Natl Acad Sci U S A (2000) 1.99
Active transport of L-glutamate by membrane vesicles isolated from rat brain. Biochemistry (1978) 1.98
Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange. J Biol Chem (1997) 1.96
Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters. J Neurosci (2005) 1.93
Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter. J Biol Chem (2000) 1.90
Binding order of substrates to the sodium and potassium ion coupled L-glutamic acid transporter from rat brain. Biochemistry (1982) 1.88
Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other. Biochemistry (2005) 1.81
Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog. Nat Struct Mol Biol (2012) 1.77
Structure of the sodium channel pore revealed by serial cysteine mutagenesis. Proc Natl Acad Sci U S A (1996) 1.67
Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2. J Neurosci (2000) 1.65
Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats. Proc Natl Acad Sci U S A (2009) 1.64
Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology. Neuron (1998) 1.62
A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop. Proc Natl Acad Sci U S A (1999) 1.51
The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate. J Biol Chem (2000) 1.46
The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits. J Neurosci (2007) 1.46
Rigidity of the subunit interfaces of the trimeric glutamate transporter GltT during translocation. J Mol Biol (2007) 1.45
Fast removal of synaptic glutamate by postsynaptic transporters. Neuron (2000) 1.44
The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits. J Neurosci (2007) 1.36
Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductance. Proc Natl Acad Sci U S A (2001) 1.30
Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1. J Biol Chem (2002) 1.30
Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter. J Biol Chem (2002) 1.30
Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis. J Biol Chem (2001) 1.29
Cone photoreceptors respond to their own glutamate release in the tiger salamander. Proc Natl Acad Sci U S A (1995) 1.29
Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ions. J Biol Chem (2001) 1.27
Glutamate 404 is involved in the substrate discrimination of GLT-1, a (Na+ + K+)-coupled glutamate transporter from rat brain. J Biol Chem (1995) 1.26
Expression of a cloned gamma-aminobutyric acid transporter in mammalian cells. Biochemistry (1992) 1.25
Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis. Proc Natl Acad Sci U S A (1996) 1.25
Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter. Proc Natl Acad Sci U S A (1999) 1.25
Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter. Proc Natl Acad Sci U S A (1998) 1.25
Unifying concept of serotonin transporter-associated currents. J Biol Chem (2011) 1.24
Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brain. Biochemistry (1990) 1.23
Arginine 445 controls the coupling between glutamate and cations in the neuronal transporter EAAC-1. J Biol Chem (2003) 1.18
Transient formation of water-conducting states in membrane transporters. Proc Natl Acad Sci U S A (2013) 1.17
Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter. J Gen Physiol (2007) 1.13
Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate. J Neurosci (2011) 1.06
Sulfhydryl modification of cysteine mutants of a neuronal glutamate transporter reveals an inverse relationship between sodium dependent conformational changes and the glutamate-gated anion conductance. Neuropharmacology (2005) 1.02
The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. J Biol Chem (2013) 0.88
Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature (2007) 2.25
Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats. Proc Natl Acad Sci U S A (2009) 1.64
Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter. J Biol Chem (2002) 1.30
Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis. J Biol Chem (2001) 1.29
Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101. J Biol Chem (2010) 1.25
Identification of a lithium interaction site in the gamma-aminobutyric acid (GABA) transporter GAT-1. J Biol Chem (2006) 1.22
The substrates of the gamma-aminobutyric acid transporter GAT-1 induce structural rearrangements around the interface of transmembrane domains 1 and 6. J Biol Chem (2008) 1.19
Arginine 445 controls the coupling between glutamate and cations in the neuronal transporter EAAC-1. J Biol Chem (2003) 1.18
Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1. J Biol Chem (2002) 1.17
Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter. J Gen Physiol (2007) 1.13
Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporter. J Biol Chem (2006) 1.12
The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands. J Biol Chem (2004) 1.11
The substrate specificity of a neuronal glutamate transporter is determined by the nature of the coupling ion. J Neurochem (2006) 1.09
The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters. Proc Natl Acad Sci U S A (2009) 1.06
Proximity of transmembrane domains 1 and 3 of the gamma-aminobutyric acid transporter GAT-1 inferred from paired cysteine mutagenesis. J Biol Chem (2005) 1.04
Sulfhydryl modification of cysteine mutants of a neuronal glutamate transporter reveals an inverse relationship between sodium dependent conformational changes and the glutamate-gated anion conductance. Neuropharmacology (2005) 1.02
Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1/EAAT2. J Biol Chem (2008) 0.99
A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter. J Biol Chem (2010) 0.96
Conformationally sensitive reactivity to permeant sulfhydryl reagents of cysteine residues engineered into helical hairpin 1 of the glutamate transporter GLT-1. Mol Pharmacol (2007) 0.95
Conserved asparagine residue located in binding pocket controls cation selectivity and substrate interactions in neuronal glutamate transporter. J Biol Chem (2012) 0.93
Transmembrane domain 8 of the {gamma}-aminobutyric acid transporter GAT-1 lines a cytoplasmic accessibility pathway into its binding pocket. J Biol Chem (2009) 0.92
A glutamine residue conserved in the neurotransmitter:sodium:symporters is essential for the interaction of chloride with the GABA transporter GAT-1. J Biol Chem (2010) 0.91
Transporter-associated currents in the gamma-aminobutyric acid transporter GAT-1 are conditionally impaired by mutations of a conserved glycine residue. J Biol Chem (2005) 0.90
An acidic amino acid transmembrane helix 10 residue conserved in the neurotransmitter:sodium:symporters is essential for the formation of the extracellular gate of the γ-aminobutyric acid (GABA) transporter GAT-1. J Biol Chem (2012) 0.86
A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transporters. J Biol Chem (2011) 0.84
Transmembrane domains I and II of the gamma-aminobutyric acid transporter GAT-4 contain molecular determinants of substrate specificity. Mol Pharmacol (2004) 0.82
Expression of neurotransmitter transporters for structural and biochemical studies. Protein Expr Purif (2010) 0.81
Functional defects in the external and internal thin gates of the γ-aminobutyric acid (GABA) transporter GAT-1 can compensate each other. J Biol Chem (2013) 0.80
Molecular physiology: intimate contact enables transport. Nature (2005) 0.78
Cysteine scanning mutagenesis of transmembrane helix 3 of a brain glutamate transporter reveals two conformationally sensitive positions. J Biol Chem (2012) 0.77
Structural biology: It's not all in the family. Nature (2008) 0.76