Published in PLoS One on February 21, 2014
Predictive identification of exonic splicing enhancers in human genes. Science (2002) 16.86
Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet (2002) 16.29
RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res (1987) 14.53
ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Res (2003) 12.81
Improved splice site detection in Genie. J Comput Biol (1997) 11.57
Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals. J Comput Biol (2004) 9.00
Systematic identification and analysis of exonic splicing silencers. Cell (2004) 8.50
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11
Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol (2001) 4.64
Computational definition of sequence motifs governing constitutive exon splicing. Genes Dev (2004) 4.59
Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell (1997) 3.85
The organization of 3' splice-site sequences in mammalian introns. Genes Dev (1989) 3.74
Functional recognition of the 3' splice site AG by the splicing factor U2AF35. Nature (1999) 3.72
Protein components specifically associated with prespliceosome and spliceosome complexes. Genes Dev (1992) 3.16
Splicing in action: assessing disease causing sequence changes. J Med Genet (2005) 3.07
Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly. Mol Cell (2004) 2.90
A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. EMBO J (1998) 2.71
A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. Genes Dev (1998) 2.64
Novel modes of splicing repression by PTB. Trends Biochem Sci (2006) 2.27
A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly. Mol Cell (2004) 2.11
Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucleic Acids Res (1997) 2.05
A mutational analysis of the polypyrimidine tract of introns. Effects of sequence differences in pyrimidine tracts on splicing. J Biol Chem (1993) 2.02
Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. Mol Cell Biol (1996) 1.90
Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes. Genome Res (2007) 1.86
Structural basis for polypyrimidine tract recognition by the essential pre-mRNA splicing factor U2AF65. Mol Cell (2006) 1.83
Evaluation of in silico splice tools for decision-making in molecular diagnosis. Hum Mutat (2008) 1.78
The role of U2AF35 and U2AF65 in enhancer-dependent splicing. RNA (2001) 1.76
Aberrant 5' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization. Nucleic Acids Res (2007) 1.71
Human-mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation. Hum Mol Genet (2005) 1.71
Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. Nature (2011) 1.57
Aberrant 3' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization. Nucleic Acids Res (2006) 1.42
Evidence for substrate-specific requirement of the splicing factor U2AF(35) and for its function after polypyrimidine tract recognition by U2AF(65). Mol Cell Biol (1999) 1.35
In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site. Mol Cell Biol (2006) 1.33
SROOGLE: webserver for integrative, user-friendly visualization of splicing signals. Nucleic Acids Res (2009) 1.32
Systematic mRNA analysis for the effect of MLH1 and MSH2 missense and silent mutations on aberrant splicing. Hum Mutat (2006) 1.25
In silico and in vivo splicing analysis of MLH1 and MSH2 missense mutations shows exon- and tissue-specific effects. BMC Genomics (2006) 1.08
AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon. Nucleic Acids Res (2011) 1.07
Multiple sequence variants of BRCA2 exon 7 alter splicing regulation. J Med Genet (2012) 0.94
Splicing mutations in glycogen-storage disease type II: evaluation of the full spectrum of mutations and their relation to patients' phenotypes. Eur J Hum Genet (2010) 0.91
U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs. Nucleic Acids Res (2013) 0.88
SMN2 exon 7 splicing is inhibited by binding of hnRNP A1 to a common ESS motif that spans the 3' splice site. Hum Mutat (2011) 0.86
Isolated growth hormone deficiency type II caused by a point mutation that alters both splice site strength and splicing enhancer function. Clin Genet (2008) 0.81
TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. J Biol Chem (2005) 3.99
The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation. RNA Biol (2010) 1.66
The TDP-43 N-terminal domain structure at high resolution. FEBS J (2016) 1.42
Cancer in the elderly. Rep Pract Oncol Radiother (2012) 1.13
Novel roles of U1 snRNP in alternative splicing regulation. RNA Biol (2010) 0.88
Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation. PLoS Biol (2016) 0.76
Systematic analysis of splicing defects in selected primary immunodeficiencies-related genes. Clin Immunol (2017) 0.75