Published in RNA on June 01, 2001
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell (2005) 4.02
Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts. Genome Res (2008) 3.33
Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts. Proc Natl Acad Sci U S A (2003) 2.65
Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Nucleic Acids Res (2005) 2.55
Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. J Biomed Sci (2004) 2.11
Introns and splicing elements of five diverse fungi. Eukaryot Cell (2004) 1.83
Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Res (2005) 1.70
Loss of exon identity is a common mechanism of human inherited disease. Genome Res (2011) 1.44
A general role for splicing enhancers in exon definition. RNA (2002) 1.43
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. Genes Dev (2011) 1.37
Systematic study of sequence motifs for RNA trans splicing in Trypanosoma brucei. Mol Cell Biol (2005) 1.36
In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site. Mol Cell Biol (2006) 1.33
Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). PLoS One (2007) 1.28
The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing. Genes Dev (2010) 1.26
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing. Mol Cell Biol (2001) 1.21
Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts. Mol Cell Biol (2003) 1.14
hnRNP A1 and hnRNP H can collaborate to modulate 5' splice site selection. RNA (2009) 1.13
Enhancer-dependent 5'-splice site control of fruitless pre-mRNA splicing. J Biol Chem (2003) 1.08
FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35. RNA (2005) 1.06
The RNAissance family: SR proteins as multifaceted regulators of gene expression. Wiley Interdiscip Rev RNA (2014) 1.05
The splicing factor U2AF small subunit is functionally conserved between fission yeast and humans. Mol Cell Biol (2004) 1.03
Exon identity crisis: disease-causing mutations that disrupt the splicing code. Genome Biol (2014) 1.02
Signal-regulated Pre-mRNA occupancy by the general splicing factor U2AF. PLoS One (2008) 1.02
Exonic splicing enhancers in fission yeast: functional conservation demonstrates an early evolutionary origin. Genes Dev (2004) 1.02
Characterization of U2AF(6), a splicing factor related to U2AF(35). Mol Cell Biol (2002) 1.01
Spatial mapping of splicing factor complexes involved in exon and intron definition. J Cell Biol (2008) 1.01
Arginine/serine repeats are sufficient to constitute a splicing activation domain. Nucleic Acids Res (2003) 1.00
Method of predicting splice sites based on signal interactions. Biol Direct (2006) 0.98
U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sites. Biochem J (2003) 0.95
The splicing regulators Tra and Tra2 are unusually potent activators of pre-mRNA splicing. Nucleic Acids Res (2006) 0.92
Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. PLoS One (2007) 0.90
Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol (2014) 0.89
Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins. Nucleic Acids Res (2014) 0.87
Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position. Nucleic Acids Res (2011) 0.86
Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J (2015) 0.85
Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns. RNA (2010) 0.84
Multiple roles for SR proteins in trans splicing. Mol Cell Biol (2002) 0.84
Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3' splice-site organization and activity of U2AF-related proteins. Nucleic Acids Res (2015) 0.82
Regulation of androgen receptor splice variant AR3 by PCGEM1. Oncotarget (2016) 0.82
A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions. Cell Rep (2014) 0.81
Splicing kinase SRPK1 conforms to the landscape of its SR protein substrate. Biochemistry (2013) 0.79
Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs. PLoS One (2011) 0.79
Exon first nucleotide mutations in splicing: evaluation of in silico prediction tools. PLoS One (2014) 0.78
Identification of a splicing enhancer in MLH1 using COMPARE, a new assay for determination of relative RNA splicing efficiencies. Hum Mol Genet (2005) 0.78
Deciphering targeting rules of splicing modulator compounds: case of TG003. BMC Mol Biol (2015) 0.76
Stoichiometries of U2AF35, U2AF65 and U2 snRNP reveal new early spliceosome assembly pathways. Nucleic Acids Res (2016) 0.76
Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons. Nucleic Acids Res (2016) 0.75
JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner. Nucleic Acids Res (2016) 0.75
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem Sci (2000) 10.77
Sorting out the complexity of SR protein functions. RNA (2000) 9.25
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Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci (2000) 7.54
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A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. Mol Cell Biol (1998) 2.62
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The SRm160/300 splicing coactivator is required for exon-enhancer function. Proc Natl Acad Sci U S A (1999) 1.62
Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects. Proc Natl Acad Sci U S A (1996) 1.60
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Evidence for substrate-specific requirement of the splicing factor U2AF(35) and for its function after polypyrimidine tract recognition by U2AF(65). Mol Cell Biol (1999) 1.35
Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo. Genes Dev (1998) 1.35
Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo. Mol Cell Biol (1998) 1.31
RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Mol Cell Biol (1998) 1.15
Distinct factor requirements for exonic splicing enhancer function and binding of U2AF to the polypyrimidine tract. J Biol Chem (1999) 1.11
Role of the constitutive splicing factors U2AF65 and SAP49 in suboptimal RNA splicing of novel retroviral mutants. J Biol Chem (1998) 0.97
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