| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Use of intensity quotients and differences in absolute structure refinement.
|
Acta Crystallogr B Struct Sci Cryst Eng Mater
|
2013
|
32.55
|
|
2
|
Metal ion roles and the movement of hydrogen during reaction catalyzed by D-xylose isomerase: a joint x-ray and neutron diffraction study.
|
Structure
|
2010
|
2.20
|
|
3
|
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.
|
J Med Chem
|
2010
|
1.84
|
|
4
|
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
|
J Med Chem
|
2005
|
1.36
|
|
5
|
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.
|
J Med Chem
|
2008
|
1.19
|
|
6
|
Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics.
|
J Biol Chem
|
2014
|
1.03
|
|
7
|
Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants.
|
J Org Chem
|
2007
|
1.01
|
|
8
|
Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds.
|
Bioorg Med Chem Lett
|
2008
|
0.88
|
|
9
|
Antimicrobial selaginellin derivatives from Selaginella pulvinata.
|
Bioorg Med Chem Lett
|
2010
|
0.88
|
|
10
|
Orally bioavailable competitive CCR5 antagonists.
|
J Med Chem
|
2004
|
0.85
|
|
11
|
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
|
J Med Chem
|
2013
|
0.83
|
|
12
|
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
|
J Med Chem
|
2013
|
0.82
|
|
13
|
Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c).
|
Acta Crystallogr D Biol Crystallogr
|
2003
|
0.81
|
|
14
|
Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.
|
Bioorg Med Chem Lett
|
2009
|
0.78
|
|
15
|
Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden.
|
Bioorg Med Chem
|
2009
|
0.78
|
|
16
|
Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues.
|
ChemMedChem
|
2008
|
0.77
|
|
17
|
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
|
J Med Chem
|
2012
|
0.77
|
|
18
|
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).
|
J Med Chem
|
2010
|
0.76
|
|
19
|
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
|
J Med Chem
|
2007
|
0.75
|
|
20
|
Structure of KNbOB2O5--a commensurately modulated structure.
|
Acta Crystallogr B
|
2005
|
0.75
|
|
21
|
C-26 vs. C-27 hydroxylation of insect steroid hormones: regioselectivity of a microsomal cytochrome P450 from a hormone-resistant cell line.
|
Arch Biochem Biophys
|
2011
|
0.75
|
|
22
|
Phyteumosides A and B: new saponins with unique triterpenoid aglycons from Phyteuma orbiculare L.
|
Org Lett
|
2011
|
0.75
|
|
23
|
DAST-mediated cyclization of α,α-disubstituted-α-acylaminoketones: efficient and divergent synthesis of unprecedented heterocycles.
|
Org Lett
|
2010
|
0.75
|
|
24
|
Novel thione-thiol rearrangement of dithiocarbonic acid O-(2,2,6,6-tetramethylpiperidin-1-yl) ester in the context of controlled radical polymerization.
|
Chimia (Aarau)
|
2010
|
0.75
|