Published in J Biol Chem on March 05, 2014
New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br J Pharmacol (2015) 0.92
Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2. PLoS One (2016) 0.89
ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget (2015) 0.89
Cellular functions of TMEM16/anoctamin. Pflugers Arch (2016) 0.89
Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia. Proc Natl Acad Sci U S A (2015) 0.88
Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation. J Biol Chem (2014) 0.85
Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer. Ann Surg Oncol (2016) 0.81
TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling. Oncotarget (2015) 0.80
Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells. Oncotarget (2016) 0.77
Evolution of an epigenetic gene ensemble within the genus Anopheles. Genome Biol Evol (2015) 0.76
Effects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio cholerae. PLoS One (2015) 0.75
Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620 Cells. PLoS One (2015) 0.75
The bestrophin- and TMEM16A-associated Ca(2+)- activated Cl(–) channels in vascular smooth muscles. Channels (Austin) (2014) 0.75
Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells. PLoS One (2017) 0.75
ANO1 plays a critical role in prostatic hyperplasia. Proc Natl Acad Sci U S A (2015) 0.75
Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A). J Med Chem (2017) 0.75
Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway. Cell (1990) 9.19
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74
TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature (2008) 8.40
Degradation of CFTR by the ubiquitin-proteasome pathway. Cell (1995) 7.88
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. J Biol Chem (1986) 6.03
Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Nature (1992) 5.45
The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol (2004) 3.84
Retracted Cytohesins are cytoplasmic ErbB receptor activators. Cell (2010) 2.74
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem (2010) 2.66
The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98
Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins. Nat Chem Biol (2011) 1.98
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol (2007) 1.85
Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J (2010) 1.71
Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol (2011) 1.68
International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol Rev (2011) 1.67
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A (2013) 1.66
Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem (2010) 1.58
Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display. Oncogene (2006) 1.56
Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci (2012) 1.55
Oncogene addiction: sometimes a temporary slavery. Cancer Cell (2004) 1.54
Large-scale systematic analysis of 2D fingerprint methods and parameters to improve virtual screening enrichments. J Chem Inf Model (2010) 1.52
High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Natl Acad Sci U S A (2002) 1.46
Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers. Cancer Biol Ther (2009) 1.45
Molecular field extrema as descriptors of biological activity: definition and validation. J Chem Inf Model (2006) 1.45
TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels. Mol Cell Proteomics (2010) 1.43
Anti-cancer, anti-diabetic and other pharmacologic and biological activities of penta-galloyl-glucose. Pharm Res (2009) 1.41
Analysis and comparison of 2D fingerprints: insights into database screening performance using eight fingerprint methods. J Mol Graph Model (2010) 1.38
Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor. Sci Signal (2013) 1.29
FieldScreen: virtual screening using molecular fields. Application to the DUD data set. J Chem Inf Model (2008) 1.22
Ubiquitylation of ion channels. Physiology (Bethesda) (2005) 1.22
Inhibition of cell proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1. Biochem Biophys Res Commun (2012) 1.20
The hydrophobic effect in protein folding. FASEB J (1995) 1.17
Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci U S A (2012) 1.17
Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res (2013) 1.09
Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A (2013) 1.02
The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med (2012) 0.93
Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem (2012) 0.91
QPatch: the missing link between HTS and ion channel drug discovery. Comb Chem High Throughput Screen (2009) 0.90
Control of TMEM16A by INO-4995 and other inositolphosphates. Br J Pharmacol (2013) 0.80
Use of intensity quotients and differences in absolute structure refinement. Acta Crystallogr B Struct Sci Cryst Eng Mater (2013) 32.55
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res (2007) 2.52
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. J Virol (2009) 2.26
Metal ion roles and the movement of hydrogen during reaction catalyzed by D-xylose isomerase: a joint x-ray and neutron diffraction study. Structure (2010) 2.20
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J Med Chem (2010) 1.84
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. Cancer Discov (2012) 1.83
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A (2013) 1.66
Cholesterol biosynthesis modulation regulates dengue viral replication. Virology (2009) 1.64
Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Res (2011) 1.46
Discovery of LFF571: an investigational agent for Clostridium difficile infection. J Med Chem (2012) 1.26
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem (2008) 1.19
Multiple cyclophilins involved in different cellular pathways mediate HCV replication. Virology (2009) 1.17
The application of errorless learning to aphasic disorders: A review of theory and practice. Neuropsychol Rehabil (2003) 1.13
Quantitative DFT modeling of the enantiomeric excess for dioxirane-catalyzed epoxidations. J Am Chem Soc (2009) 1.08
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol Pharmacol (2003) 1.05
Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Mol Cancer Res (2008) 1.02
Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants. J Org Chem (2007) 1.01
A new multiword naming deficit: Evidence and interpretation. Cogn Neuropsychol (2002) 0.95
Biodiversity of small molecules--a new perspective in screening set selection. Drug Discov Today (2013) 0.90
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential. Bioorg Med Chem Lett (2005) 0.89
Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. Bioorg Med Chem Lett (2008) 0.88
Antimicrobial selaginellin derivatives from Selaginella pulvinata. Bioorg Med Chem Lett (2010) 0.88
Recent trends and observations in the design of high-quality screening collections. Future Med Chem (2011) 0.87
An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential. J Cheminform (2011) 0.86
MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Mol Cell Biol (2011) 0.86
Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation. J Biol Chem (2014) 0.85
Orally bioavailable competitive CCR5 antagonists. J Med Chem (2004) 0.85
Atomic-scale characterization of conformational changes in the preQ₁ riboswitch aptamer upon ligand binding. J Mol Graph Model (2011) 0.84
Avoidance of the Ames test liability for aryl-amines via computation. Bioorg Med Chem (2011) 0.84
Localized orbital corrections for the calculation of barrier heights in density functional theory. J Chem Theory Comput (2009) 0.84
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors. J Med Chem (2011) 0.84
Optimization procedure for small interfering RNA transfection in a 384-well format. J Biomol Screen (2007) 0.84
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore. J Med Chem (2013) 0.83
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett (2012) 0.83
Identification of elongation factor G as the conserved cellular target of argyrin B. PLoS One (2012) 0.83
GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett (2009) 0.82
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches. J Med Chem (2013) 0.82
Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c). Acta Crystallogr D Biol Crystallogr (2003) 0.81
The chemical tuning of a weak zinc binding motif for histone deacetylase using electronic effects. Chem Biol Drug Des (2012) 0.80
Circulating osteoprotegerin and leptin levels in postmenopausal women with and without osteoporosis. Rom J Intern Med (2003) 0.78
Automated ligand- and structure-based protocol for in silico prediction of human serum albumin binding. J Chem Inf Model (2013) 0.78
GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett (2010) 0.78
Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead. Bioorg Med Chem Lett (2009) 0.78
Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden. Bioorg Med Chem (2009) 0.78
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. J Med Chem (2011) 0.78
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate. J Med Chem (2012) 0.77
Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues. ChemMedChem (2008) 0.77
Dynamics of inflammatory markers in post-acute stroke patients undergoing rehabilitation. Inflammation (2011) 0.77
The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors. Bioorg Med Chem Lett (2011) 0.76
New highly potent and selective adenosine A(3) receptor antagonists. Curr Top Med Chem (2004) 0.76
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J Med Chem (2010) 0.76
The development of automated patch clamp assays for canonical transient receptor potential channels TRPC3, 6, and 7. Assay Drug Dev Technol (2014) 0.76
Using a two-step hydride transfer to achieve 1,4-reduction in the catalytic hydrogenation of an acyl pyridinium cation. J Org Chem (2008) 0.75
Antibacterial and Solubility Optimization of Thiomuracin A. J Med Chem (2016) 0.75
DAST-mediated cyclization of α,α-disubstituted-α-acylaminoketones: efficient and divergent synthesis of unprecedented heterocycles. Org Lett (2010) 0.75
Novel thione-thiol rearrangement of dithiocarbonic acid O-(2,2,6,6-tetramethylpiperidin-1-yl) ester in the context of controlled radical polymerization. Chimia (Aarau) (2010) 0.75
Structure of KNbOB2O5--a commensurately modulated structure. Acta Crystallogr B (2005) 0.75
Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters. Bioorg Med Chem (2004) 0.75
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin. J Med Chem (2007) 0.75
Polarized Raman spectroscopy of oligothiophene crystals to determine unit cell orientation. J Phys Chem A (2012) 0.75
C-26 vs. C-27 hydroxylation of insect steroid hormones: regioselectivity of a microsomal cytochrome P450 from a hormone-resistant cell line. Arch Biochem Biophys (2011) 0.75
Application of non-parametric regression to quantitative structure-activity relationships. Bioorg Med Chem (2002) 0.75
Phyteumosides A and B: new saponins with unique triterpenoid aglycons from Phyteuma orbiculare L. Org Lett (2011) 0.75