PubRank

Hashim M Al-Hashimi

Author PubWeight™ 70.02‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Visualizing spatially correlated dynamics that directs RNA conformational transitions. Nature 2007 3.25
2 Transient Hoogsteen base pairs in canonical duplex DNA. Nature 2011 2.46
3 Resolving the motional modes that code for RNA adaptation. Science 2006 2.15
4 Functional complexity and regulation through RNA dynamics. Nature 2012 2.07
5 Topology links RNA secondary structure with global conformation, dynamics, and adaptation. Science 2010 2.00
6 Dynamics of large elongated RNA by NMR carbon relaxation. J Am Chem Soc 2007 1.41
7 Visualizing transient low-populated structures of RNA. Nature 2012 1.36
8 NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings. Biopolymers 2007 1.36
9 Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nat Chem Biol 2011 1.31
10 Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis. Biophys J 2008 1.24
11 Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy. J Am Chem Soc 2009 1.24
12 Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition. Nucleic Acids Res 2009 1.21
13 Argininamide binding arrests global motions in HIV-1 TAR RNA: comparison with Mg2+-induced conformational stabilization. J Mol Biol 2004 1.21
14 Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy. Nat Methods 2011 1.20
15 Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints. J Magn Reson 2006 1.16
16 Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar couplings. Nat Protoc 2007 1.16
17 Impact of static and dynamic A-form heterogeneity on the determination of RNA global structural dynamics using NMR residual dipolar couplings. J Biomol NMR 2006 1.16
18 Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine. J Am Chem Soc 2006 1.11
19 3D maps of RNA interhelical junctions. Nat Protoc 2011 1.10
20 Probing transient Hoogsteen hydrogen bonds in canonical duplex DNA using NMR relaxation dispersion and single-atom substitution. J Am Chem Soc 2012 1.10
21 A general method for constructing atomic-resolution RNA ensembles using NMR residual dipolar couplings: the basis for interhelical motions revealed. J Am Chem Soc 2013 1.09
22 Probing motions between equivalent RNA domains using magnetic field induced residual dipolar couplings: accounting for correlations between motions and alignment. J Am Chem Soc 2003 1.06
23 Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch. Nucleic Acids Res 2011 1.06
24 Resolving fast and slow motions in the internal loop containing stem-loop 1 of HIV-1 that are modulated by Mg2+ binding: role in the kissing-duplex structural transition. Nucleic Acids Res 2007 1.06
25 Probing Na(+)-induced changes in the HIV-1 TAR conformational dynamics using NMR residual dipolar couplings: new insights into the role of counterions and electrostatic interactions in adaptive recognition. Biochemistry 2007 1.05
26 Hierarchy of RNA functional dynamics. Annu Rev Biochem 2014 1.04
27 Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation. Curr Opin Struct Biol 2011 1.04
28 RNA dynamics by design: biasing ensembles towards the ligand-bound state. Angew Chem Int Ed Engl 2010 1.03
29 Extending the NMR spatial resolution limit for RNA by motional couplings. Nat Methods 2008 1.02
30 iRED analysis of TAR RNA reveals motional coupling, long-range correlations, and a dynamical hinge. Biophys J 2007 1.01
31 Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9. J Biol Chem 2011 0.99
32 Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. Nucleic Acids Res 2013 0.98
33 Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. J Am Chem Soc 2013 0.97
34 Beyond static structures of RNA by NMR: folding, refolding, and dynamics at atomic resolution. Biopolymers 2007 0.96
35 Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. RNA 2006 0.96
36 Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition. RNA 2009 0.96
37 Coarse grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges. J Phys Chem B 2014 0.95
38 Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA. J Am Chem Soc 2013 0.94
39 Probing sequence-specific DNA flexibility in a-tracts and pyrimidine-purine steps by nuclear magnetic resonance (13)C relaxation and molecular dynamics simulations. Biochemistry 2012 0.93
40 Utility of 1H NMR chemical shifts in determining RNA structure and dynamics. J Phys Chem B 2013 0.93
41 New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation. Nucleic Acids Res 2011 0.93
42 Constructing atomic-resolution RNA structural ensembles using MD and motionally decoupled NMR RDCs. Methods 2009 0.92
43 Advances in the determination of nucleic acid conformational ensembles. Annu Rev Phys Chem 2013 0.91
44 Ultrahigh resolution characterization of domain motions and correlations by multialignment and multireference residual dipolar coupling NMR. J Phys Chem B 2008 0.90
45 Sequence-specific B-DNA flexibility modulates Z-DNA formation. J Am Chem Soc 2011 0.90
46 A historical account of hoogsteen base-pairs in duplex DNA. Biopolymers 2013 0.90
47 Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility. Angew Chem Int Ed Engl 2005 0.88
48 Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer. Biochemistry 2010 0.86
49 Variable helix elongation as a tool to modulate RNA alignment and motional couplings. J Magn Reson 2009 0.85
50 Carbon sequestration in Synechococcus Sp.: from molecular machines to hierarchical modeling. OMICS 2002 0.84
51 NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. Biopolymers 2010 0.84
52 Preparation, resonance assignment, and preliminary dynamics characterization of residue specific 13C/15N-labeled elongated DNA for the study of sequence-directed dynamics by NMR. J Biomol NMR 2009 0.83
53 Approximate reconstruction of continuous spatially complex domain motions by multialignment NMR residual dipolar couplings. J Phys Chem B 2009 0.83
54 Using fluorine nuclear magnetic resonance to probe changes in the structure and dynamics of membrane-active peptides interacting with lipid bilayers. Biochemistry 2011 0.81
55 Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis. ACS Chem Biol 2014 0.80
56 Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release. Mol Pharm 2012 0.79
57 An RNA tertiary switch by modifying how helices are tethered. Genome Biol 2014 0.79
58 Thermodynamics of RNA melting, one base pair at a time. RNA 2010 0.79
59 Influence of dimethylsulfoxide on RNA structure and ligand binding. Anal Chem 2013 0.78
60 NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Proc Natl Acad Sci U S A 2010 0.78
61 Guanine to inosine substitution leads to large increases in the population of a transient G·C Hoogsteen base pair. Biochemistry 2014 0.76
62 Incorporation of CC steps into Z-DNA: interplay between B-Z junction and Z-DNA helical formation. Biochemistry 2012 0.76
63 Structural biology: Aerial view of the HIV genome. Nature 2009 0.75
64 A rare example of lock-and-key RNA recognition. J Mol Biol 2010 0.75
65 RNA structure: Adding a second dimension. Nat Chem 2011 0.75
66 120 Role of dynamic base pair polymorphism in the central dogma of molecular biology. J Biomol Struct Dyn 2015 0.75