1
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Cytoplasmic steps of peptidoglycan biosynthesis.
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FEMS Microbiol Rev
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2008
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2.33
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2
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Recent advances in design, synthesis and biological activity of aminoalkylsulfonates and sulfonamidopeptides.
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Curr Med Chem
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2004
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1.16
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3
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Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.
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J Med Chem
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2010
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1.15
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4
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Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1.
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J Med Chem
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2010
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1.10
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5
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Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds.
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ChemMedChem
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2011
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0.97
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6
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Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase.
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J Mol Biol
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2007
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0.95
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7
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Biochemical characterization and physiological properties of Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase.
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J Bacteriol
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2007
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0.92
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8
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Discovery of novel benzene 1,3-dicarboxylic acid inhibitors of bacterial MurD and MurE ligases by structure-based virtual screening approach.
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Bioorg Med Chem Lett
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2009
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0.92
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9
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Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme.
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J Med Chem
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2008
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0.92
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10
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5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases.
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ChemMedChem
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2010
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0.91
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11
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Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF.
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Bioorg Chem
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2009
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0.88
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12
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Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.
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J Med Chem
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2014
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0.88
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13
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False positives in the early stages of drug discovery.
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Curr Med Chem
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2010
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0.87
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14
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New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.
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PLoS One
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2011
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0.87
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15
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Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB).
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Bioorg Med Chem Lett
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2009
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0.87
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16
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Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3).
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Mol Cell Endocrinol
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2005
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0.86
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17
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Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl).
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Bioorg Med Chem Lett
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2007
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0.86
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18
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Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening.
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Bioorg Med Chem
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2009
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0.85
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19
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Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD.
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Bioorg Med Chem Lett
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2005
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0.84
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20
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New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation.
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Eur J Med Chem
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2011
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0.84
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21
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Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
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Mol Cell Endocrinol
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2008
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0.84
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22
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Novel inhibitors of trihydroxynaphthalene reductase with antifungal activity identified by ligand-based and structure-based virtual screening.
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J Chem Inf Model
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2011
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0.83
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23
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Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD).
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J Med Chem
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2011
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0.83
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24
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Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid.
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Eur J Med Chem
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2011
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0.83
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25
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Recent advances in the synthesis and applications of reduced amide pseudopeptides.
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Curr Med Chem
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2009
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0.83
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26
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Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library.
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J Med Chem
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2012
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0.83
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27
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Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.
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J Med Chem
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2014
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0.83
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28
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Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1.
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Mol Cell Endocrinol
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2006
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0.82
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29
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Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic Acid-based inhibitors of penicillin-binding proteins.
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Acta Chim Slov
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2012
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0.82
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30
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Phosphinate inhibitors of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase (MurE).
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Arch Pharm (Weinheim)
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2007
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0.82
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31
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Melanin is crucial for growth of the black yeast Hortaea werneckii in its natural hypersaline environment.
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Fungal Biol
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2013
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0.81
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32
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Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety.
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PLoS One
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2011
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0.81
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33
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N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.
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Bioorg Med Chem Lett
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2012
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0.81
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34
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Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening.
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Eur J Med Chem
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2013
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0.81
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35
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Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.
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J Leukoc Biol
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2011
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0.80
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36
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Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase.
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Bioorg Med Chem Lett
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2008
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0.80
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37
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Endocrine disruptome--an open source prediction tool for assessing endocrine disruption potential through nuclear receptor binding.
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J Chem Inf Model
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2014
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0.80
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38
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Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.
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J Med Chem
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2013
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0.80
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39
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6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase.
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PLoS One
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2012
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0.80
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40
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Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.
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Eur J Med Chem
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2013
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0.80
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41
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Virtual screening for potential inhibitors of bacterial MurC and MurD ligases.
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J Mol Model
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2011
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0.80
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42
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New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3.
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Eur J Med Chem
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2009
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0.80
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43
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MurD enzymes from different bacteria: evaluation of inhibitors.
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Biochem Pharmacol
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2012
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0.79
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44
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Design and synthesis of novel N-benzylidenesulfonohydrazide inhibitors of MurC and MurD as potential antibacterial agents.
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Molecules
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2008
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0.79
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45
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Flavonoids and cinnamic acid esters as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase: a synthesis, QSAR and modelling study.
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Bioorg Med Chem
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2006
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0.79
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46
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Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites.
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Eur J Med Chem
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2011
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0.79
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47
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Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening.
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J Med Chem
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2008
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0.78
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48
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Novel inhibitors of beta-ketoacyl-ACP reductase from Escherichia coli.
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Chem Biol Interact
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2008
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0.78
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49
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Discovery of new inhibitors of aldo-keto reductase 1C1 by structure-based virtual screening.
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Mol Cell Endocrinol
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2008
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0.78
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50
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Discovery of highly potent, nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors by virtual high-throughput screening.
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J Steroid Biochem Mol Biol
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2011
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0.78
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51
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MurD enzymes: some recent developments.
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Biomol Concepts
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2013
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0.78
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52
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Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.
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Biochem Pharmacol
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2011
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0.78
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53
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Development of screening assays and discovery of initial inhibitors of pneumococcal peptidoglycan deacetylase PgdA.
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Biochem Pharmacol
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2011
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0.77
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54
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2,3-Diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17β-hydroxysteroid dehydrogenase (AKR1C3).
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Eur J Med Chem
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2013
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0.77
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55
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New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: inhibition of antigen 85C mycolyltransferase activity and cytotoxicity.
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J Enzyme Inhib Med Chem
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2006
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0.77
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56
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Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase.
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Bioorg Med Chem
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2011
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0.77
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57
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Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion.
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Biol Chem
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2016
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0.77
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58
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Selective cytotoxicity of amidinopiperidine based compounds towards Burkitt's lymphoma cells involves proteasome inhibition.
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PLoS One
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2012
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0.77
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59
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Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity.
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Dalton Trans
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2014
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0.77
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60
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Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B.
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Eur J Med Chem
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2011
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0.77
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61
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Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
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J Steroid Biochem Mol Biol
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2012
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0.76
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62
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Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.
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Bioorg Med Chem
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2008
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0.76
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63
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Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases.
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ChemMedChem
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2008
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0.76
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64
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Design, Synthesis and in vitro Biochemical Activity of Novel Amino Acid Sulfonohydrazide Inhibitors of MurC.
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Acta Chim Slov
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2011
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0.76
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65
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New enzymatic assay for the AKR1C enzymes.
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Chem Biol Interact
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2012
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0.76
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66
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The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors.
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PLoS One
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2012
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0.76
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67
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Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.
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J Biol Chem
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2013
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0.76
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68
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Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC-MurF): experimental and computational characterization.
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J Comput Aided Mol Des
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2015
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0.76
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69
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Crystallization and preliminary X-ray analysis of a UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (PaMurF) from Pseudomonas aeruginosa.
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Acta Crystallogr Sect F Struct Biol Cryst Commun
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2013
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0.75
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70
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Molecular dynamics to enhance structure-based virtual screening on cathepsin B.
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J Comput Aided Mol Des
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2015
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0.75
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71
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Function of the D-alanine:D-alanine ligase lid loop: a molecular modeling and bioactivity study.
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J Med Chem
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2012
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0.75
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72
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Inhibitor design strategy based on an enzyme structural flexibility: a case of bacterial MurD ligase.
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J Chem Inf Model
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2014
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0.75
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73
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Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.
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Steroids
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2005
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0.75
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74
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Synthesis and Biological Evaluation of N-Aryl-N'-(5-(2-hydroxybenzoyl) pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists.
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Med Chem
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2016
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0.75
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75
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Design and synthesis of substrate mimetics based on an indole scaffold: potential inhibitors of 17β-HSD type 1.
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Horm Mol Biol Clin Investig
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2011
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0.75
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76
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Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl).
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Biochimie
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2012
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0.75
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77
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Cinnamic acid derivatives induce cell cycle arrest in carcinoma cell lines.
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Med Chem
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2013
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0.75
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78
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Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity.
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Dalton Trans
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2016
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0.75
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79
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Virtual screening yields inhibitors of novel antifungal drug target, benzoate 4-monooxygenase.
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J Chem Inf Model
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2012
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0.75
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80
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Cinnamates and cinnamamides inhibit fungal 17beta-hydroxysteroid dehydrogenase.
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Mol Cell Endocrinol
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2005
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0.75
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81
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New inhibitors of fungal 17beta-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold.
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J Enzyme Inhib Med Chem
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2007
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0.75
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82
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Biochemical characterization of MurF from Streptococcus pneumoniae and the identification of a new MurF inhibitor through ligand-based virtual screening.
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Acta Chim Slov
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2013
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0.75
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83
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Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.
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Steroids
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2005
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0.75
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84
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The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and In Vivo Activity.
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J Med Chem
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2017
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0.75
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85
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Design and Synthesis of New Peptidomimetics as Potential Inhibitors of MurE.
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Acta Chim Slov
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2011
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0.75
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