Stanislav Gobec

Author PubWeight™ 59.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cytoplasmic steps of peptidoglycan biosynthesis. FEMS Microbiol Rev 2008 2.33
2 Recent advances in design, synthesis and biological activity of aminoalkylsulfonates and sulfonamidopeptides. Curr Med Chem 2004 1.16
3 Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase. J Med Chem 2010 1.15
4 Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1. J Med Chem 2010 1.10
5 Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds. ChemMedChem 2011 0.97
6 Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase. J Mol Biol 2007 0.95
7 Biochemical characterization and physiological properties of Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase. J Bacteriol 2007 0.92
8 Discovery of novel benzene 1,3-dicarboxylic acid inhibitors of bacterial MurD and MurE ligases by structure-based virtual screening approach. Bioorg Med Chem Lett 2009 0.92
9 Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J Med Chem 2008 0.92
10 5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases. ChemMedChem 2010 0.91
11 Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF. Bioorg Chem 2009 0.88
12 Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis. J Med Chem 2014 0.88
13 False positives in the early stages of drug discovery. Curr Med Chem 2010 0.87
14 New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. PLoS One 2011 0.87
15 Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Bioorg Med Chem Lett 2009 0.87
16 Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3). Mol Cell Endocrinol 2005 0.86
17 Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl). Bioorg Med Chem Lett 2007 0.86
18 Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening. Bioorg Med Chem 2009 0.85
19 Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD. Bioorg Med Chem Lett 2005 0.84
20 New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation. Eur J Med Chem 2011 0.84
21 Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. Mol Cell Endocrinol 2008 0.84
22 Novel inhibitors of trihydroxynaphthalene reductase with antifungal activity identified by ligand-based and structure-based virtual screening. J Chem Inf Model 2011 0.83
23 Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD). J Med Chem 2011 0.83
24 Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid. Eur J Med Chem 2011 0.83
25 Recent advances in the synthesis and applications of reduced amide pseudopeptides. Curr Med Chem 2009 0.83
26 Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library. J Med Chem 2012 0.83
27 Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor. J Med Chem 2014 0.83
28 Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1. Mol Cell Endocrinol 2006 0.82
29 Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic Acid-based inhibitors of penicillin-binding proteins. Acta Chim Slov 2012 0.82
30 Phosphinate inhibitors of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase (MurE). Arch Pharm (Weinheim) 2007 0.82
31 Melanin is crucial for growth of the black yeast Hortaea werneckii in its natural hypersaline environment. Fungal Biol 2013 0.81
32 Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety. PLoS One 2011 0.81
33 N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3. Bioorg Med Chem Lett 2012 0.81
34 Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening. Eur J Med Chem 2013 0.81
35 Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells. J Leukoc Biol 2011 0.80
36 Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase. Bioorg Med Chem Lett 2008 0.80
37 Endocrine disruptome--an open source prediction tool for assessing endocrine disruption potential through nuclear receptor binding. J Chem Inf Model 2014 0.80
38 Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem 2013 0.80
39 6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase. PLoS One 2012 0.80
40 Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem 2013 0.80
41 Virtual screening for potential inhibitors of bacterial MurC and MurD ligases. J Mol Model 2011 0.80
42 New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem 2009 0.80
43 MurD enzymes from different bacteria: evaluation of inhibitors. Biochem Pharmacol 2012 0.79
44 Design and synthesis of novel N-benzylidenesulfonohydrazide inhibitors of MurC and MurD as potential antibacterial agents. Molecules 2008 0.79
45 Flavonoids and cinnamic acid esters as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase: a synthesis, QSAR and modelling study. Bioorg Med Chem 2006 0.79
46 Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites. Eur J Med Chem 2011 0.79
47 Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening. J Med Chem 2008 0.78
48 Novel inhibitors of beta-ketoacyl-ACP reductase from Escherichia coli. Chem Biol Interact 2008 0.78
49 Discovery of new inhibitors of aldo-keto reductase 1C1 by structure-based virtual screening. Mol Cell Endocrinol 2008 0.78
50 Discovery of highly potent, nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors by virtual high-throughput screening. J Steroid Biochem Mol Biol 2011 0.78
51 MurD enzymes: some recent developments. Biomol Concepts 2013 0.78
52 Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochem Pharmacol 2011 0.78
53 Development of screening assays and discovery of initial inhibitors of pneumococcal peptidoglycan deacetylase PgdA. Biochem Pharmacol 2011 0.77
54 2,3-Diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17β-hydroxysteroid dehydrogenase (AKR1C3). Eur J Med Chem 2013 0.77
55 New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: inhibition of antigen 85C mycolyltransferase activity and cytotoxicity. J Enzyme Inhib Med Chem 2006 0.77
56 Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase. Bioorg Med Chem 2011 0.77
57 Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion. Biol Chem 2016 0.77
58 Selective cytotoxicity of amidinopiperidine based compounds towards Burkitt's lymphoma cells involves proteasome inhibition. PLoS One 2012 0.77
59 Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity. Dalton Trans 2014 0.77
60 Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B. Eur J Med Chem 2011 0.77
61 Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins. J Steroid Biochem Mol Biol 2012 0.76
62 Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening. Bioorg Med Chem 2008 0.76
63 Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases. ChemMedChem 2008 0.76
64 Design, Synthesis and in vitro Biochemical Activity of Novel Amino Acid Sulfonohydrazide Inhibitors of MurC. Acta Chim Slov 2011 0.76
65 New enzymatic assay for the AKR1C enzymes. Chem Biol Interact 2012 0.76
66 The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors. PLoS One 2012 0.76
67 Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. J Biol Chem 2013 0.76
68 Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC-MurF): experimental and computational characterization. J Comput Aided Mol Des 2015 0.76
69 Crystallization and preliminary X-ray analysis of a UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (PaMurF) from Pseudomonas aeruginosa. Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 0.75
70 Molecular dynamics to enhance structure-based virtual screening on cathepsin B. J Comput Aided Mol Des 2015 0.75
71 Function of the D-alanine:D-alanine ligase lid loop: a molecular modeling and bioactivity study. J Med Chem 2012 0.75
72 Inhibitor design strategy based on an enzyme structural flexibility: a case of bacterial MurD ligase. J Chem Inf Model 2014 0.75
73 Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase. Steroids 2005 0.75
74 Synthesis and Biological Evaluation of N-Aryl-N'-(5-(2-hydroxybenzoyl) pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists. Med Chem 2016 0.75
75 Design and synthesis of substrate mimetics based on an indole scaffold: potential inhibitors of 17β-HSD type 1. Horm Mol Biol Clin Investig 2011 0.75
76 Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl). Biochimie 2012 0.75
77 Cinnamic acid derivatives induce cell cycle arrest in carcinoma cell lines. Med Chem 2013 0.75
78 Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity. Dalton Trans 2016 0.75
79 Virtual screening yields inhibitors of novel antifungal drug target, benzoate 4-monooxygenase. J Chem Inf Model 2012 0.75
80 Cinnamates and cinnamamides inhibit fungal 17beta-hydroxysteroid dehydrogenase. Mol Cell Endocrinol 2005 0.75
81 New inhibitors of fungal 17beta-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold. J Enzyme Inhib Med Chem 2007 0.75
82 Biochemical characterization of MurF from Streptococcus pneumoniae and the identification of a new MurF inhibitor through ligand-based virtual screening. Acta Chim Slov 2013 0.75
83 Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase. Steroids 2005 0.75
84 The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and In Vivo Activity. J Med Chem 2017 0.75
85 Design and Synthesis of New Peptidomimetics as Potential Inhibitors of MurE. Acta Chim Slov 2011 0.75