Published in Radiother Oncol on March 13, 2014
Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24
The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. Mol Cancer Ther (2015) 0.77
Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384. Clin Cancer Res (2015) 0.77
Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand. Clin Cancer Res (2015) 0.77
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia. Nat Commun (2016) 0.75
Improved Methods to Generate Spheroid Cultures from Tumor Cells, Tumor Cells & Fibroblasts or Tumor-Fragments: Microenvironment, Microvesicles and MiRNA. PLoS One (2015) 0.75
MATE2 Expression Is Associated with Cancer Cell Response to Metformin. PLoS One (2016) 0.75
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway. Mol Cancer (2017) 0.75
Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas. Oncotarget (2016) 0.75
High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94
The phosphoinositide 3-kinase pathway. Science (2002) 24.72
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science (2005) 23.44
Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell (2008) 5.34
Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc (2009) 3.65
Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol (2004) 3.63
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol (1996) 3.59
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell (2007) 3.54
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem (2000) 3.02
Hypoxic radiosensitization: adored and ignored. J Clin Oncol (2007) 2.67
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc Natl Acad Sci U S A (2000) 2.46
Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39
Blood flow in microvascular networks. Experiments and simulation. Circ Res (1990) 2.34
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res (2008) 2.30
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging. Cancer Res (2008) 2.15
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J Neurochem (2003) 2.15
Automated selection of DAB-labeled tissue for immunohistochemical quantification. J Histochem Cytochem (2003) 2.07
Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial. J Clin Oncol (2012) 1.96
Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells. Cancer Res (2005) 1.86
A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol (2008) 1.70
Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol (1995) 1.66
Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. Mol Cancer Res (2006) 1.65
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer Res (2009) 1.64
Green's function methods for analysis of oxygen delivery to tissue by microvascular networks. Ann Biomed Eng (2004) 1.52
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci U S A (2013) 1.42
Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PLoS One (2009) 1.37
ARCON: a novel biology-based approach in radiotherapy. Lancet Oncol (2002) 1.37
Tumor vascular changes mediated by inhibition of oncogenic signaling. Cancer Res (2009) 1.35
Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer. Clin Cancer Res (2008) 1.35
Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. Cancer Res (2011) 1.30
Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res (2008) 1.29
The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. Neoplasia (2012) 1.28
PI3 kinase inhibitors in the clinic: an update. Anticancer Res (2012) 1.19
Liquid-overlay culture of cellular spheroids. Recent Results Cancer Res (1984) 1.14
NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiat Oncol (2012) 1.11
Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium. J Mol Cell Cardiol (2009) 1.09
Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One (2011) 1.07
Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines. J Nucl Med (2009) 1.06
Clinical studies of hypoxia modification in radiotherapy. Semin Radiat Oncol (2004) 1.02
Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor. Eur J Cancer (2009) 1.01
Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy. Radiat Res (2009) 0.96
Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy. Cancer Sci (2011) 0.96
Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors. Cancer Res (2011) 0.95
Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer. Radiother Oncol (1998) 0.87
PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med (2013) 0.87
Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide. Br J Cancer Suppl (1996) 0.86
Combining mTOR inhibition with radiation improves antitumor activity in bladder cancer cells in vitro and in vivo: a novel strategy for treatment. PLoS One (2013) 0.86
Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells. J Cell Physiol (2013) 0.85
Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation. Hepatology (2013) 0.82
Inhibition of rapamycin-induced AKT activation elicits differential antitumor response in head and neck cancers. Cancer Res (2013) 0.81