Published in Cell on March 06, 2012
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PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N Engl J Med (2012) 3.39
Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell (2014) 2.25
The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity (2013) 2.13
PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Cell Metab (2014) 2.01
Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab (2012) 1.87
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol (2015) 1.78
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol (2015) 1.61
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Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther (2013) 1.19
Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ (2013) 1.19
PTEN in cancer, metabolism, and aging. Trends Endocrinol Metab (2012) 1.18
Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol (2013) 1.13
The regulation of cellular metabolism by tumor suppressor p53. Cell Biosci (2013) 1.12
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism. Cancer Metab (2013) 1.12
mTOR and metabolic pathways in T cell quiescence and functional activation. Semin Immunol (2013) 1.11
A joint analysis of metabolomics and genetics of breast cancer. Breast Cancer Res (2014) 1.04
MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase. Cancer Res (2012) 1.04
Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene (2014) 1.04
Regulation of the pentose phosphate pathway in cancer. Protein Cell (2014) 1.03
Conceptual framework for cutting the pancreatic cancer fuel supply. Clin Cancer Res (2012) 1.02
Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS Pathog (2013) 1.01
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism. EMBO Mol Med (2013) 1.01
Calorie restriction and cancer prevention: a mechanistic perspective. Cancer Metab (2013) 1.01
Adaptive mitochondrial reprogramming and resistance to PI3K therapy. J Natl Cancer Inst (2015) 1.00
Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. PLoS One (2012) 1.00
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nat Cell Biol (2016) 1.00
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state. Mol Cell Biol (2014) 0.99
Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells. Cancer Res (2013) 0.95
Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background. Toxicol Sci (2013) 0.94
Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618. Neoplasia (2013) 0.94
Potential of telomerase activation in extending health span and longevity. Curr Opin Cell Biol (2012) 0.92
Re-thinking cell cycle regulators: the cross-talk with metabolism. Front Oncol (2013) 0.92
MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. J Clin Invest (2014) 0.92
Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells. J Biol Chem (2013) 0.91
Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem (2012) 0.90
PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Stem Cells (2014) 0.90
6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. Cell Death Dis (2014) 0.90
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism. Cancer Metab (2014) 0.89
Glucocorticoid receptor β stimulates Akt1 growth pathway by attenuation of PTEN. J Biol Chem (2014) 0.89
Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2014) 0.87
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence". Cancer Metastasis Rev (2013) 0.86
Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. Oncotarget (2014) 0.85
Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN. Sci Rep (2015) 0.85
Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia. Radiother Oncol (2014) 0.85
Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence. Cell Death Dis (2014) 0.84
Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development. PLoS One (2014) 0.84
PTEN deficiency and mutant p53 confer glucose-addiction to thyroid cancer cells: impact of glucose depletion on cell proliferation, cell survival, autophagy and cell migration. Genes Cancer (2014) 0.84
Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model. Am J Pathol (2014) 0.83
Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3). J Biol Chem (2014) 0.83
Involvement of estrogen receptor β5 in the progression of glioma. Brain Res (2013) 0.81
PTEN is a negative regulator of NK cell cytolytic function. J Immunol (2015) 0.81
High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene. Mol Metab (2015) 0.81
T-cell energy metabolism as a controller of cell fate in transplantation. Curr Opin Organ Transplant (2015) 0.81
Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state. Oncotarget (2016) 0.81
Targeting the ABCG2-overexpressing multidrug resistant (MDR) cancer cells by PPARγ agonists. Br J Pharmacol (2013) 0.81
Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer. Cancer Gene Ther (2015) 0.80
Restricting carbohydrates to fight head and neck cancer-is this realistic? Cancer Biol Med (2014) 0.80
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol (2015) 0.80
Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics. Mol Cancer Ther (2016) 0.80
In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma. Oncotarget (2015) 0.80
Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling. Front Physiol (2012) 0.80
GUCY2C: at the intersection of obesity and cancer. Trends Endocrinol Metab (2013) 0.79
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. J Clin Invest (2016) 0.79
Metabolic reprogramming: a hallmark of viral oncogenesis. Oncogene (2015) 0.79
PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells. Oncotarget (2016) 0.79
Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages. Sci Rep (2015) 0.78
The sweet trap in tumors: aerobic glycolysis and potential targets for therapy. Oncotarget (2016) 0.78
Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies. Cell Cycle (2014) 0.78
Emerging roles of p53 and other tumour-suppressor genes in immune regulation. Nat Rev Immunol (2016) 0.78
Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice. Sci Rep (2015) 0.78
Multiplexed immunofluorescence delineates proteomic cancer cell states associated with metabolism. JCI Insight (2016) 0.77
Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus. Reprod Sci (2013) 0.77
Sex differences in skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: a cross-sectional study. Sci Rep (2015) 0.77
Hyaluronic acid induces activation of the κ-opioid receptor. PLoS One (2013) 0.77
Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell Death Differ (2016) 0.77
Attacking the supply wagons to starve cancer cells to death. FEBS Lett (2016) 0.77
WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner. Oncogene (2017) 0.77
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest (2016) 0.76
A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approaches. PLoS Comput Biol (2014) 0.76
Pro-tumorigenic role of ERα in prostate cancer cells. Aging (Albany NY) (2015) 0.76
Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis. PLoS One (2016) 0.75
Molecular Characterization of the Dominant-Negative Role of Cancer-Associated PTEN: Sometimes, Null is Better. Front Oncol (2014) 0.75
Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster. PLoS One (2015) 0.75
Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line. Sci Rep (2017) 0.75
Insights into APC/C: from cellular function to diseases and therapeutics. Cell Div (2016) 0.75
Increased Arf/p53 activity in stem cells, aging and cancer. Aging Cell (2017) 0.75
A PTEN translational isoform has PTEN-like activity. Chin J Cancer Res (2015) 0.75
DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. Cell Discov (2017) 0.75
PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer. PLoS One (2016) 0.75
PI3Kα inhibition reduces obesity in mice. Aging (Albany NY) (2016) 0.75
Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach. Sci Rep (2017) 0.75
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Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature (2009) 8.70
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Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature (2013) 6.53
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ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A (2005) 6.35
A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat Med (2013) 6.09
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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
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Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry. Science (2007) 4.41
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell (2005) 4.36
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The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol (2008) 4.15
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