Published in Nature on March 23, 2014
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. Cell (2015) 2.63
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Data-driven prediction and design of bZIP coiled-coil interactions. PLoS Comput Biol (2015) 1.46
UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci (2015) 1.34
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J (2014) 1.15
Druggable sensors of the unfolded protein response. Nat Chem Biol (2014) 1.09
Stress responses from the endoplasmic reticulum in cancer. Front Oncol (2015) 1.03
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Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun (2014) 0.88
Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases. Semin Cancer Biol (2015) 0.88
RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Res (2016) 0.87
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The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cells. Oncogene (2015) 0.83
Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. Int Rev Cell Mol Biol (2015) 0.83
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Hypoxia signaling pathways: modulators of oxygen-related organelles. Front Cell Dev Biol (2015) 0.82
Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response. Cell Rep (2015) 0.82
ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway. Oncogene (2014) 0.82
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Molecular mechanisms of human IRE1 activation through dimerization and ligand binding. Oncotarget (2015) 0.81
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Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions. Oncotarget (2015) 0.80
NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer. Mol Cell Biol (2014) 0.80
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget (2015) 0.80
Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway. PLoS Genet (2014) 0.80
Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget (2016) 0.80
Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo. Aging Cell (2016) 0.79
The transcription factor X-box binding protein-1 in neurodegenerative diseases. Mol Neurodegener (2014) 0.79
Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer. Proc Natl Acad Sci U S A (2015) 0.79
Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly. J Clin Med (2015) 0.79
IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis. J Clin Invest (2015) 0.78
Chemical induction of unfolded protein response enhances cancer cell killing through lytic virus infection. J Virol (2014) 0.78
Anticipatory UPR Activation: A Protective Pathway and Target in Cancer. Trends Endocrinol Metab (2016) 0.78
Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers. Front Oncol (2015) 0.78
The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome. Oncoimmunology (2016) 0.78
A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells. Pharmacol Res (2016) 0.78
Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity. Oncotarget (2015) 0.77
Lactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line. Cell J (2016) 0.77
Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment. Clin Cancer Res (2016) 0.77
Adipose tissue dysfunction and its effects on tumor metabolism. Horm Mol Biol Clin Investig (2015) 0.77
Prostate cancer and the unfolded protein response. Oncotarget (2016) 0.77
p38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. Stem Cells (2015) 0.77
Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development. Mol Cell Biol (2015) 0.77
Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease. Front Cell Dev Biol (2017) 0.77
Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3(+)CD8(+) T cells against Various Solid Tumors. J Leuk (Los Angel) (2015) 0.76
OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Sci Rep (2015) 0.76
Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy. Oncoimmunology (2015) 0.76
NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer. Oncogene (2016) 0.76
GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action. Oncotarget (2015) 0.76
The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression. Oncotarget (2016) 0.76
A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1. Oncotarget (2015) 0.76
Elementary: breast cancer culprits leave their signatures on the double helix. Cell Death Differ (2016) 0.75
Dual role for the unfolded protein response in the ovary: adaption and apoptosis. Protein Cell (2016) 0.75
ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget (2016) 0.75
The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease. Mol Med (2017) 0.75
Do signal transduction cascades influence survival in triple-negative breast cancer? A preliminary study. Onco Targets Ther (2016) 0.75
Adaptive Stress Responses During Tumor Metastasis and Dormancy. Trends Cancer (2016) 0.75
Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death. Cell Death Dis (2017) 0.75
Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer. J Exp Clin Cancer Res (2016) 0.75
Tauroursodeoxycholic acid reduces the invasion of MDA-MB-231 cells by modulating matrix metalloproteinases 7 and 13. Oncol Lett (2016) 0.75
Breast cancer: Hypoxia and XBP1S. Nat Rev Cancer (2014) 0.75
ONC201 activates ER stress to inhibit the growth of triple-negative breast cancer cells. Oncotarget (2017) 0.75
XBP1 splicing triggers miR-150 transfer from smooth muscle cells to endothelial cells via extracellular vesicles. Sci Rep (2016) 0.75
Molecular signal networks and regulating mechanisms of the unfolded protein response. J Zhejiang Univ Sci B (2017) 0.75
Incorporating prior biological knowledge for network-based differential gene expression analysis using differentially weighted graphical LASSO. BMC Bioinformatics (2017) 0.75
Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers. Breast Cancer Res (2016) 0.75
The BH3 mimetic drug ABT-737 induces apoptosis and acts synergistically with chemotherapeutic drugs in thyroid carcinoma cells. Cancer Cell Int (2016) 0.75
XBP1 induces MMP-9 expression to promote proliferation and invasion in human esophageal squamous cell carcinoma. Am J Cancer Res (2016) 0.75
Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther (2016) 0.75
Cancer: A dendritic-cell brake on antitumour immunity. Nature (2015) 0.75
PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes. JCI Insight (2017) 0.75
An unexpected alliance between stress responses to drive oncogenesis. Breast Cancer Res (2014) 0.75
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer. Cell (2017) 0.75
Endoplasmic reticulum stress induces secretion of high-mobility group proteins and is associated with tumor-infiltrating lymphocytes in triple-negative breast cancer. Oncotarget (2016) 0.75
Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer. J Immunother Cancer (2017) 0.75
Action of nicotinic acid on the reversion of hypoxic-inflammatory link on 3T3-L1 adipocytes. Lipids Health Dis (2016) 0.75
State-of-the-art of regulatory dendritic cells in cancer. Pharmacol Ther (2016) 0.75
Systematic Identification and Assessment of Therapeutic Targets for Breast Cancer Based on Genome-Wide RNA Interference Transcriptomes. Genes (Basel) (2017) 0.75
Phosphorylated eIF2α predicts disease-free survival in triple-negative breast cancer patients. Sci Rep (2017) 0.75
Regulation of hypoxia responses by flavin adenine dinucleotide-dependent modulation of HIF-1α protein stability. EMBO J (2017) 0.75
MINT: a multivariate integrative method to identify reproducible molecular signatures across independent experiments and platforms. BMC Bioinformatics (2017) 0.75
Hypoxia-induced HIF1α targets in melanocytes reveal a molecular profile associated with poor melanoma prognosis. Pigment Cell Melanoma Res (2017) 0.75
The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics. Front Oncol (2017) 0.75
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway. Sci Rep (2017) 0.75
Endoplasmic Reticulum Proteostasis: A Key Checkpoint in Cancer. Am J Physiol Cell Physiol (2016) 0.75
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation. Sci Rep (2017) 0.75
Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers. Oncogenesis (2017) 0.75
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