1
|
Rapid DNA methylation changes after exposure to traffic particles.
|
Am J Respir Crit Care Med
|
2009
|
5.20
|
2
|
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.
|
Am J Respir Crit Care Med
|
2009
|
4.64
|
3
|
MMP12, lung function, and COPD in high-risk populations.
|
N Engl J Med
|
2009
|
3.96
|
4
|
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age.
|
Am J Clin Nutr
|
2007
|
3.89
|
5
|
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
|
N Engl J Med
|
2011
|
3.80
|
6
|
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study.
|
J Allergy Clin Immunol
|
2010
|
3.54
|
7
|
Variants in FAM13A are associated with chronic obstructive pulmonary disease.
|
Nat Genet
|
2010
|
3.44
|
8
|
Maternal vitamin D intake during pregnancy and early childhood wheezing.
|
Am J Clin Nutr
|
2007
|
3.40
|
9
|
Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality.
|
Crit Care Med
|
2012
|
2.97
|
10
|
Statin use reduces decline in lung function: VA Normative Aging Study.
|
Am J Respir Crit Care Med
|
2007
|
2.65
|
11
|
The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
|
Am J Hum Genet
|
2005
|
2.46
|
12
|
Uric acid and the development of hypertension: the normative aging study.
|
Hypertension
|
2006
|
2.45
|
13
|
Association of low serum 25-hydroxyvitamin D levels and sepsis in the critically ill.
|
Crit Care Med
|
2014
|
2.38
|
14
|
Association between prehospital vitamin D status and hospital-acquired bloodstream infections.
|
Am J Clin Nutr
|
2013
|
2.21
|
15
|
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).
|
Hum Mol Genet
|
2004
|
2.19
|
16
|
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
|
Nat Genet
|
2011
|
2.10
|
17
|
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations.
|
Am J Respir Cell Mol Biol
|
2005
|
2.08
|
18
|
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
|
Hum Mol Genet
|
2011
|
1.98
|
19
|
Genetic determinants of emphysema distribution in the national emphysema treatment trial.
|
Am J Respir Crit Care Med
|
2007
|
1.94
|
20
|
Vitamin D deficiency in pregnancy and gestational diabetes mellitus.
|
Am J Obstet Gynecol
|
2012
|
1.93
|
21
|
Association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill.
|
Crit Care Med
|
2012
|
1.78
|
22
|
Vitamin D deficiency, smoking, and lung function in the Normative Aging Study.
|
Am J Respir Crit Care Med
|
2012
|
1.75
|
23
|
Maternal diet vs lack of exposure to sunlight as the cause of the epidemic of asthma, allergies and other autoimmune diseases.
|
Thorax
|
2007
|
1.67
|
24
|
Long-term effects of traffic particles on lung function decline in the elderly.
|
Am J Respir Crit Care Med
|
2014
|
1.66
|
25
|
Sensitization to mouse allergen and asthma and asthma morbidity among women in Boston.
|
J Allergy Clin Immunol
|
2007
|
1.60
|
26
|
Air pollution and ST-segment depression in elderly subjects.
|
Environ Health Perspect
|
2005
|
1.56
|
27
|
African ancestry and lung function in Puerto Rican children.
|
J Allergy Clin Immunol
|
2012
|
1.54
|
28
|
Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood.
|
J Allergy Clin Immunol
|
2007
|
1.53
|
29
|
Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children.
|
Am J Respir Crit Care Med
|
2012
|
1.46
|
30
|
Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits.
|
Curr Med Res Opin
|
2013
|
1.44
|
31
|
FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma.
|
J Allergy Clin Immunol
|
2007
|
1.40
|
32
|
Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program.
|
J Allergy Clin Immunol
|
2008
|
1.36
|
33
|
Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study.
|
Cancer Causes Control
|
2010
|
1.30
|
34
|
Predictors of cord blood IgE levels in children at risk for asthma and atopy.
|
J Allergy Clin Immunol
|
2006
|
1.27
|
35
|
Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life.
|
Lancet
|
2002
|
1.27
|
36
|
Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years.
|
Am J Respir Crit Care Med
|
2002
|
1.26
|
37
|
Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging study.
|
Chest
|
2007
|
1.25
|
38
|
Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants.
|
Ann Epidemiol
|
2012
|
1.24
|
39
|
Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.
|
Hum Mol Genet
|
2005
|
1.23
|
40
|
Low-normal gestational age as a predictor of asthma at 6 years of age.
|
Pediatrics
|
2004
|
1.18
|
41
|
Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children.
|
J Allergy Clin Immunol
|
2008
|
1.18
|
42
|
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.
|
J Nutr
|
2005
|
1.17
|
43
|
The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility.
|
Am J Respir Cell Mol Biol
|
2011
|
1.17
|
44
|
A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease.
|
Am J Respir Cell Mol Biol
|
2005
|
1.14
|
45
|
Endotoxin exposure and eczema in the first year of life.
|
Pediatrics
|
2004
|
1.13
|
46
|
Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma.
|
Respiration
|
2010
|
1.13
|
47
|
Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study.
|
J Clin Endocrinol Metab
|
2014
|
1.12
|
48
|
Genetics of sputum gene expression in chronic obstructive pulmonary disease.
|
PLoS One
|
2011
|
1.11
|
49
|
Gestational intake of methyl donors and global LINE-1 DNA methylation in maternal and cord blood: prospective results from a folate-replete population.
|
Epigenetics
|
2012
|
1.10
|
50
|
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.
|
PLoS Genet
|
2012
|
1.09
|
51
|
Mode of delivery and cord blood cytokines: a birth cohort study.
|
Clin Mol Allergy
|
2006
|
1.07
|
52
|
Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility.
|
Physiol Genomics
|
2006
|
1.05
|
53
|
Sensitization to aeroallergens and airway hyperresponsiveness at 7 years of age.
|
Chest
|
2006
|
1.05
|
54
|
Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers.
|
BMC Med Genet
|
2011
|
1.04
|
55
|
Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease.
|
Am J Respir Cell Mol Biol
|
2010
|
1.04
|
56
|
Prevalence and titer of IgE antibodies to mouse allergens.
|
J Allergy Clin Immunol
|
2007
|
1.03
|
57
|
Pre-hospital vitamin D concentration, mortality, and bloodstream infection in a hospitalized patient population.
|
Am J Med
|
2013
|
1.01
|
58
|
Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years.
|
Am J Respir Crit Care Med
|
2002
|
1.00
|
59
|
Predictors of poor response during asthma therapy differ with definition of outcome.
|
Pharmacogenomics
|
2009
|
0.99
|
60
|
Associations of LINE-1 DNA Methylation with Preterm Birth in a Prospective Cohort Study.
|
J Dev Orig Health Dis
|
2012
|
0.99
|
61
|
Ambient air pollution and oxygen saturation.
|
Am J Respir Crit Care Med
|
2004
|
0.99
|
62
|
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema.
|
Am J Respir Cell Mol Biol
|
2009
|
0.98
|
63
|
Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma.
|
Pharmacogenet Genomics
|
2008
|
0.98
|
64
|
Diversity of the gut microbiota and eczema in early life.
|
Clin Mol Allergy
|
2008
|
0.97
|
65
|
The in utero effects of maternal vitamin D deficiency: how it results in asthma and other chronic diseases.
|
Am J Respir Crit Care Med
|
2011
|
0.95
|
66
|
Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D.
|
J Allergy Clin Immunol
|
2012
|
0.95
|
67
|
Gene promoter methylation is associated with lung function in the elderly: the Normative Aging Study.
|
Epigenetics
|
2012
|
0.95
|
68
|
Bottle feeding in the bed or crib before sleep time and wheezing in early childhood.
|
Pediatrics
|
2002
|
0.94
|
69
|
Diagnostic accuracy of the bronchodilator response in children.
|
J Allergy Clin Immunol
|
2013
|
0.93
|
70
|
Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.
|
Pharmacogenet Genomics
|
2008
|
0.93
|
71
|
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report.
|
COPD
|
2011
|
0.93
|
72
|
Association of variants in innate immune genes with asthma and eczema.
|
Pediatr Allergy Immunol
|
2011
|
0.93
|
73
|
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.
|
Hum Genet
|
2013
|
0.92
|
74
|
Predicting response to short-acting bronchodilator medication using Bayesian networks.
|
Pharmacogenomics
|
2009
|
0.92
|
75
|
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.
|
Thorax
|
2011
|
0.91
|
76
|
Genetic and histologic evidence for autophagy in asthma pathogenesis.
|
J Allergy Clin Immunol
|
2011
|
0.91
|
77
|
Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.
|
PLoS One
|
2013
|
0.91
|
78
|
Cord blood cytokines and acute lower respiratory illnesses in the first year of life.
|
Pediatrics
|
2006
|
0.90
|
79
|
Day care attendance, respiratory tract illnesses, wheezing, asthma, and total serum IgE level in early childhood.
|
Arch Pediatr Adolesc Med
|
2002
|
0.90
|
80
|
Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children.
|
J Allergy Clin Immunol
|
2010
|
0.90
|
81
|
Paternal history of asthma and airway responsiveness in children with asthma.
|
Am J Respir Crit Care Med
|
2005
|
0.89
|
82
|
Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men.
|
Atherosclerosis
|
2009
|
0.89
|
83
|
Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes.
|
BMC Med Genet
|
2011
|
0.89
|
84
|
Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.
|
Genomics
|
2013
|
0.89
|
85
|
Genetic linkage and association analysis of COPD-related traits on chromosome 8p.
|
COPD
|
2006
|
0.89
|
86
|
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
|
Am J Respir Crit Care Med
|
2010
|
0.89
|
87
|
Respiratory illnesses in early life and asthma and atopy in childhood.
|
J Allergy Clin Immunol
|
2006
|
0.89
|
88
|
Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.
|
Am J Respir Crit Care Med
|
2010
|
0.88
|
89
|
Genome-wide association analysis of circulating vitamin D levels in children with asthma.
|
Hum Genet
|
2012
|
0.88
|
90
|
SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development.
|
Am J Respir Crit Care Med
|
2011
|
0.88
|
91
|
Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.
|
Am J Respir Crit Care Med
|
2010
|
0.87
|
92
|
Association between 24-hour urinary cadmium and pulmonary function among community-exposed men: the VA Normative Aging Study.
|
Environ Health Perspect
|
2008
|
0.86
|
93
|
Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.
|
J Allergy Clin Immunol
|
2011
|
0.86
|
94
|
Prenatal, perinatal, and heritable influences on cord blood immune responses.
|
Ann Allergy Asthma Immunol
|
2006
|
0.85
|
95
|
Folliculin mutations are not associated with severe COPD.
|
BMC Med Genet
|
2008
|
0.85
|
96
|
Forced expiratory volume in 1 second and cognitive aging in men.
|
J Am Geriatr Soc
|
2011
|
0.85
|
97
|
Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.
|
Environ Health Perspect
|
2009
|
0.85
|
98
|
Alu and LINE-1 methylation and lung function in the normative ageing study.
|
BMJ Open
|
2012
|
0.85
|
99
|
Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease.
|
Am J Respir Cell Mol Biol
|
2008
|
0.83
|
100
|
Very important pharmacogene summary for VDR.
|
Pharmacogenet Genomics
|
2012
|
0.82
|
101
|
Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.
|
BMC Med Genet
|
2011
|
0.82
|
102
|
Allergen sensitization is associated with increased DNA methylation in older men.
|
Int Arch Allergy Immunol
|
2012
|
0.81
|
103
|
Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1.
|
BMC Med Genet
|
2011
|
0.81
|
104
|
Early pregnancy vitamin D status and risk of preeclampsia.
|
J Clin Invest
|
2016
|
0.80
|
105
|
Serum cytokine levels, cigarette smoking and airway responsiveness among pregnant women.
|
Int Arch Allergy Immunol
|
2003
|
0.80
|
106
|
Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.
|
J Nutr
|
2012
|
0.80
|
107
|
Relevance and implication of genetic determinants to asthma pathophysiology.
|
Curr Opin Allergy Clin Immunol
|
2011
|
0.78
|
108
|
Genome-wide association studies of family data in pharmacogenetics: a case study.
|
Curr Pharm Des
|
2009
|
0.77
|
109
|
Vitamin D, the gut microbiome, and the hygiene hypothesis. How does asthma begin?
|
Am J Respir Crit Care Med
|
2015
|
0.77
|
110
|
Vitamin D insufficiency.
|
N Engl J Med
|
2011
|
0.76
|
111
|
Vitamin D and corticosteroids in asthma: synergy, interaction and potential therapeutic effects.
|
Expert Rev Respir Med
|
2013
|
0.76
|
112
|
INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.
|
Clin Med Pediatr
|
2009
|
0.75
|
113
|
Exposure to traffic and early life respiratory infection: A cohort study.
|
Pediatr Pulmonol
|
2014
|
0.75
|