Published in Science on June 23, 1989
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Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. J Gen Physiol (1997) 1.49
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Demonstration of a [K+,Cl-]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive [Na+,K+,Cl-]-cotransport system. Mol Pharmacol (1988) 1.43
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Inhibition of na/h antiport activity in sugar beet tonoplast by analogs of amiloride. Plant Physiol (1987) 1.36
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Separation of the osmotically driven fusion event from vesicle-planar membrane attachment in a model system for exocytosis. J Cell Biol (1984) 1.33
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Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors. Biophys J (1999) 1.32
Regulation of cell pH by Ca+2-mediated exocytotic insertion of H+-ATPases. J Cell Biol (1986) 1.30
Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes. J Biol Chem (1993) 1.28
Structure-activity relationships of amiloride and certain of its analogues in relation to the blockade of the Na+/H+ exchange system. Mol Pharmacol (1984) 1.28
Modulation of the hyperpolarization-activated Cl- current in human intestinal T84 epithelial cells by phosphorylation. J Physiol (1996) 1.25
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Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. J Biol Chem (1986) 1.24
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pH regulation in spread cells and round cells. J Biol Chem (1990) 1.22
Inhibition of Na+/Ca2+ exchange in pituitary plasma membrane vesicles by analogues of amiloride. Biochemistry (1985) 1.20
Regulation of the sodium permeability of the luminal border of toad bladder by intracellular sodium and calcium: role of sodium-calcium exchange in the basolateral membrane. J Gen Physiol (1981) 1.20
Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3. J Biol Chem (1992) 1.19
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Interaction between sodium and chloride transport in canine tracheal mucosa. J Appl Physiol Respir Environ Exerc Physiol (1979) 1.19
Characterization of potent Na+/H+ exchange inhibitors from the amiloride series in A431 cells. Biochemistry (1984) 1.19
Hensin remodels the apical cytoskeleton and induces columnarization of intercalated epithelial cells: processes that resemble terminal differentiation. J Cell Biol (1999) 1.18
Inhibition of chemotactic factor-activated Na+/H+ exchange in human neutrophils by analogues of amiloride: structure-activity relationships in the amiloride series. Mol Pharmacol (1986) 1.18
Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol (1987) 1.17
Hensin, a new collecting duct protein involved in the in vitro plasticity of intercalated cell polarity. J Clin Invest (1996) 1.17
Amiloride, a specific inhibitor for the Na+-driven flagellar motors of alkalophilic Bacillus. J Biol Chem (1988) 1.15
Proton-translocating adenosinetriphosphatase in rough and smooth microsomes from rat liver. Biochemistry (1984) 1.15
Interferon-gamma downregulates CFTR gene expression in epithelial cells. Am J Physiol (1994) 1.14
Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin. J Biol Chem (1985) 1.13
Regulation of intracellular pH in cultured hippocampal neurons by an amiloride-insensitive Na+/H+ exchanger. J Biol Chem (1991) 1.13
An endothelial growth factor involved in rat renal development. J Clin Invest (1998) 1.12
Location of a high affinity Zn2+ binding site in the channel of alpha1beta1 gamma-aminobutyric acidA receptors. Mol Pharmacol (1998) 1.12
Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive. J Biol Chem (1987) 1.12
Specific inhibition of the Na(+)-driven flagellar motors of alkalophilic Bacillus strains by the amiloride analog phenamil. J Bacteriol (1990) 1.12
Photolabeling of tonoplast from sugar beet cell suspensions by [h]5-(N-methyl-N-isobutyl)-amiloride, an inhibitor of the vacuolar na/h antiport. Plant Physiol (1990) 1.11
The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+/H+ antiport. Circ Res (1989) 1.11
Rescue from programmed cell death in leukemic and normal myeloid cells. Blood (1991) 1.10
Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange. J Biol Chem (1985) 1.09
Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. Biochimie (1988) 1.09
Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol. J Gen Physiol (1990) 1.08
Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy. Br J Cancer (1993) 1.07
Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step. J Biol Chem (1986) 1.07
Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins. J Cell Sci (1995) 1.06
Fusion of phospholipid vesicles with a planar membrane depends on the membrane permeability of the solute used to create the osmotic pressure. J Gen Physiol (1989) 1.05
Estimation of the number and turnover rate of Na+/H+ exchangers in lymphocytes. Effect of phorbol ester and osmotic shrinking. J Biol Chem (1987) 1.05
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Arg352 is a major determinant of charge selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel. Biochemistry (1999) 1.04
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Chemical modification of cell proliferation and fluid secretion in renal cysts. Kidney Int (1989) 1.03
NMR measurements of Na+ and cellular energy in ischemic rat heart: role of Na(+)-H+ exchange. Am J Physiol (1993) 1.03
Blastocoel expansion in the preimplantation mouse embryo: role of extracellular sodium and chloride and possible apical routes of their entry. Dev Biol (1989) 1.02
Urinary acidification in turtle bladder is due to a reversible proton-translocating ATPase. Proc Natl Acad Sci U S A (1979) 1.02
Characterization of Na+-linked and Na+-independent Cl-/HCO3- exchange systems in Chinese hamster lung fibroblasts. J Biol Chem (1988) 1.02
Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform. J Biol Chem (1993) 1.02
Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am J Physiol (1999) 1.01
Effect of plant cytokinins on microfilaments and tight junction permeability. Nature (1976) 1.01
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