Published in J Cardiovasc Pharmacol on January 01, 1989
Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest (1991) 3.18
Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest (1990) 2.61
Endothelial modulation and changes in endothelin pressor activity during hypoxia in the rat isolated perfused superior mesenteric arterial bed. Br J Pharmacol (1991) 0.88
Endothelin-1 does not mediate hypoxic vasoconstriction in canine isolated blood vessels: effect of BQ-123. Br J Pharmacol (1993) 0.78
Increase in immunoreactivity to endothelin-1 in the mucosal vasculature and epithelium of the large intestine during chronic hypoxia. J Anat (1994) 0.77
The effect of endothelins on nitric oxide and prostacyclin production from human umbilical vein, porcine aorta and bovine carotid artery endothelial cells in culture. Br J Pharmacol (1993) 0.77
Tetramisole (R 8299), a new, potent broad spectrum anthelmintic. Nature (1966) 30.39
Protein interaction mapping in C. elegans using proteins involved in vulval development. Science (2000) 11.61
GATEWAY recombinational cloning: application to the cloning of large numbers of open reading frames or ORFeomes. Methods Enzymol (2000) 7.46
Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nat Genet (2001) 7.16
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell (1992) 6.32
Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Genome Res (2001) 5.10
A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature (1989) 4.17
Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. Genes Dev (1998) 4.06
Open-reading-frame sequence tags (OSTs) support the existence of at least 17,300 genes in C. elegans. Nat Genet (2001) 4.03
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. J Mol Biol (1994) 3.85
The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75
Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci (1981) 3.71
The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro. Cancer Res (1976) 3.52
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. J Pharmacol Exp Ther (1981) 3.47
Identification of a family of human F-box proteins. Curr Biol (1999) 3.31
High-throughput yeast two-hybrid assays for large-scale protein interaction mapping. Methods (2001) 3.09
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99
RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev (1996) 2.92
Hepatitis C virus infection protein network. Mol Syst Biol (2008) 2.91
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron (2000) 2.82
Modulation of vascular smooth muscle contraction by the endothelium. Annu Rev Physiol (1986) 2.76
A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome. EMBO Rep (2001) 2.74
Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J (1990) 2.56
A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc Natl Acad Sci U S A (1996) 2.54
Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development. Differentiation (1994) 2.53
The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol Cell Biol (1989) 2.52
High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation (1997) 2.51
Yeast two-hybrid systems and protein interaction mapping projects for yeast and worm. Yeast (2000) 2.51
Screening patients for heterozygous p53 mutations using a functional assay in yeast. Nat Genet (1993) 2.40
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives. Proc Natl Acad Sci U S A (1991) 2.37
KEEPS: The Kronos Early Estrogen Prevention Study. Climacteric (2005) 2.32
Protein interaction maps for model organisms. Nat Rev Mol Cell Biol (2001) 2.32
The preparation and antimycotic properties of derivatives of 1-phenethylimidazole. J Med Chem (1969) 2.28
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev (1997) 2.26
Ketoconazole -- a new broad spectrum orally active antimycotic. Experientia (1979) 2.24
Isolation and Characterization of an Enterobacter cloacae Strain That Reduces Hexavalent Chromium under Anaerobic Conditions. Appl Environ Microbiol (1989) 2.23
Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals. Biochem Soc Trans (1990) 2.22
Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development (2001) 2.21
Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity. J Virol (1990) 2.19
Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction. J Vasc Surg (1994) 2.13
RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J (1999) 2.11
[Evaluation of functional capability after hospital admission of nonagenarian patients]. Med Clin (Barc) (2000) 2.01
Inhibition and induction of microsomal enzymes in rat. A comparative study of four antimycotics: miconazole, econazole, clotrimazole and ketoconazole. Arch Int Pharmacodyn Ther (1981) 2.00
Survival benefit of high ligation of the inferior mesenteric artery in sigmoid colon or rectal cancer surgery. Br J Surg (2006) 1.95
Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke (2000) 1.83
Itraconazole, a new triazole that is orally active in aspergillosis. Antimicrob Agents Chemother (1984) 1.83
Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2001) 1.79
Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. J Pharm Pharmacol (1978) 1.76
Endothelium and control of vascular function. State of the Art lecture. Hypertension (1989) 1.75
A heterodimeric DNA polymerase: evidence that members of Euryarchaeota possess a distinct DNA polymerase. Proc Natl Acad Sci U S A (1998) 1.70
Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke (1989) 1.70
Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J (1997) 1.67
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol (1996) 1.65
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine. Arzneimittelforschung (1974) 1.65
Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models. Rev Infect Dis (1987) 1.64
Transient bilateral cortical blindness after coronary angiography. Lancet (1998) 1.64
High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes. Genes Dev (1989) 1.63
Adventitia-dependent relaxations of canine basilar arteries transduced with recombinant eNOS gene. Am J Physiol (1999) 1.62
Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. Am J Pathol (2001) 1.61
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease. Am J Physiol Regul Integr Comp Physiol (2000) 1.60
The effect of estrogen replacement therapy on plasma nitric oxide and endothelin-1 levels in postmenopausal women. Ann Intern Med (1998) 1.60
Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ (2008) 1.58
Effect of 17 beta-estradiol on endothelium-dependent responses in the rabbit. J Pharmacol Exp Ther (1988) 1.57
eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis. Cardiovasc Res (2000) 1.53
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat Struct Biol (1995) 1.53
Licensed midwife-attended, out-of-hospital births in Washington state: are they safe? Birth (1994) 1.52
The antiinflammatory effects of ketoconazole. A comparative study with hydrocortisone acetate in a model using living and killed Staphylococcus aureus on the skin of guinea-pigs. J Am Acad Dermatol (1991) 1.52
A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res (1991) 1.51
In vitro evaluation of endothelial and smooth muscle function of primary varicose veins. J Vasc Surg (1992) 1.51
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues. Arzneimittelforschung (1974) 1.51
Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice. Development (2000) 1.50
Effect of statin therapy on restenosis after coronary stent implantation. Am J Cardiol (2000) 1.50
In vitro activity of R 61837, a new antirhinovirus compound. Arch Virol (1988) 1.49
Crystal structure of the archaeal holliday junction resolvase Hjc and implications for DNA recognition. Structure (2001) 1.47
Crystal structure of an archaeal intein-encoded homing endonuclease PI-PfuI. J Mol Biol (2000) 1.46
Functional interactions of a homolog of proliferating cell nuclear antigen with DNA polymerases in Archaea. J Bacteriol (1999) 1.45
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. Bioorg Med Chem Lett (2001) 1.44
Production of monoclonal antibodies against mammalian Ring1B proteins. Hybridoma (2001) 1.44
Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse. Kidney Int (2008) 1.43
Dominant-negative p53 mutations selected in yeast hit cancer hot spots. Proc Natl Acad Sci U S A (1996) 1.42
Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation. Circ Res (1992) 1.42
Statin therapy is associated with reduced restenosis rates after coronary stent implantation in carriers of the Pl(A2)allele of the platelet glycoprotein IIIa gene. Eur Heart J (2001) 1.42
In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity. Antimicrob Agents Chemother (1992) 1.42
Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection. Antimicrob Agents Chemother (1992) 1.41
Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. Mol Biol Cell (2001) 1.41
New best estimates for radionuclide solid-liquid distribution coefficients in soils. Part 3: miscellany of radionuclides (Cd, Co, Ni, Zn, I, Se, Sb, Pu, Am, and others). J Environ Radioact (2008) 1.40
Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses (1989) 1.38
A novel DNA polymerase family found in Archaea. J Bacteriol (1998) 1.37
Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins. Circ Res (1990) 1.37
Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice. Proc Natl Acad Sci U S A (1989) 1.37
The archaeal DNA primase: biochemical characterization of the p41-p46 complex from Pyrococcus furiosus. J Biol Chem (2001) 1.36
The absolute configurations of the optical isomers of the broad spectrum anthelmintic tetramisole. Tetrahedron Lett (1967) 1.36
Exosomes released during reticulocyte maturation bind to fibronectin via integrin alpha4beta1. Eur J Biochem (2000) 1.35
Suppression of colds in human volunteers challenged with rhinovirus by a new synthetic drug (R61837). Antimicrob Agents Chemother (1989) 1.33
Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced "Cheroing" and "agitation" in rats. Arzneimittelforschung (1967) 1.33
Endothelial alpha 2-adrenoceptors in canine pulmonary and systemic blood vessels. Eur J Pharmacol (1985) 1.33
Hepatic reactions during ketoconazole treatment. Am J Med (1983) 1.32
Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins. J Virol (1997) 1.32
Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function. J Biol Chem (2000) 1.31
Distribution and properties of excitatory and inhibitory junction potentials in circular muscle of the guinea-pig stomach. J Physiol (1986) 1.31