Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.

PubWeight™: 1.67‹?› | Rank: Top 3%

🔗 View Article (PMC 4309842)

Published in Nat Immunol on April 28, 2014

Authors

Susanne Roth1, Andrea Rottach2, Amelie S Lotz-Havla3, Verena Laux1, Andreas Muschaweckh4, Søren W Gersting3, Ania C Muntau3, Karl-Peter Hopfner5, Lei Jin6, Katelynd Vanness7, John H J Petrini7, Ingo Drexler8, Heinrich Leonhardt2, Jürgen Ruland1

Author Affiliations

1: Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
2: Department Biology II and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Martinsried, Germany.
3: Kinderklinik und Kinderpoliklinik im Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität, Munich, Germany.
4: Institut für Virologie, Klinikum rechts der Isar, Technische Universität München, and Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany.
5: Department of Biochemistry, Gene Center and Center for integrated Protein Science Munich, Ludwig-Maximilians-Universität, Munich, Germany.
6: Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA.
7: Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
8: 1] Institut für Virologie, Klinikum rechts der Isar, Technische Universität München, and Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany. [2] Institut für Virologie, Universitätsklinikum Düsseldorf, Heinrich Heine Universität, Düsseldorf, Germany.

Articles citing this

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo. Nat Commun (2016) 1.43

The CARD9 Polymorphisms rs4077515, rs10870077 and rs10781499 Are Uncoupled from Susceptibility to and Severity of Pulmonary Tuberculosis. PLoS One (2016) 1.41

Innate immune recognition of DNA: A recent history. Virology (2015) 1.10

Discriminating self from non-self in nucleic acid sensing. Nat Rev Immunol (2016) 1.02

Activation and regulation of DNA-driven immune responses. Microbiol Mol Biol Rev (2015) 0.92

International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation. Immunity (2015) 0.84

The role of the gut and microbes in the pathogenesis of spondyloarthritis. Best Pract Res Clin Rheumatol (2014) 0.82

Interleukin-1- and type I interferon-dependent enhanced immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletions of type I and type II interferon-binding proteins. J Virol (2015) 0.79

The role of Card9 overexpression in peripheral blood mononuclear cells from patients with aseptic acute pancreatitis. J Cell Mol Med (2015) 0.78

Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity. Sci Rep (2015) 0.78

Cellular and molecular regulation of innate inflammatory responses. Cell Mol Immunol (2016) 0.76

CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages. Nat Commun (2016) 0.76

Kaposi sarcoma herpesvirus pathogenesis. Philos Trans R Soc Lond B Biol Sci (2017) 0.76

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency. PLoS Pathog (2017) 0.75

A new cytosolic DNA-recognition pathway for DNA-induced inflammatory responses. Cell Mol Immunol (2014) 0.75

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. Elife (2017) 0.75

Immunochip analysis identifies association of the RAD50/IL13 region with human longevity. Aging Cell (2016) 0.75

Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation. Nat Immunol (2014) 0.75

DNA Damage Response and Immune Defense: Links and Mechanisms. Front Genet (2016) 0.75

Localisation of double-strand break repair proteins to viral replication compartments following lytic reactivation of KSHV. J Virol (2017) 0.75

Kaposi's Sarcoma Herpesvirus Latency-Associated Nuclear Antigen (LANA): Replicating and Shielding Viral DNA during Viral Persistence. J Virol (2017) 0.75

Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer. Eur J Immunol (2017) 0.75

Articles cited by this

Pattern recognition receptors and inflammation. Cell (2010) 21.05

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80

Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol (2009) 11.76

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47

Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature (2009) 9.74

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol (2009) 7.93

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol (2010) 7.47

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science (2012) 7.08

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell (1998) 6.58

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol (2010) 5.79

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature (2006) 5.34

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol (2011) 5.34

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov (2012) 4.40

The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol (1997) 4.11

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature (2002) 3.99

The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 3.80

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol (2006) 3.76

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol (2009) 3.58

Cytosolic sensing of viruses. Immunity (2013) 3.54

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science (2013) 3.10

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A (1999) 3.06

Immune sensing of DNA. Immunity (2013) 2.96

MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol (2011) 2.31

Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol (2009) 2.23

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis. J Immunol (1988) 2.13

Using or abusing: viruses and the cellular DNA damage response. Trends Microbiol (2007) 2.12

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Transl Med (2011) 1.74

Vaccinia virus morphogenesis and dissemination. Trends Microbiol (2008) 1.73

Interactions of viruses with the cellular DNA repair machinery. DNA Repair (Amst) (2004) 1.72

Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. Elife (2012) 1.53

Multicolor 3D fluorescence in situ hybridization for imaging interphase chromosomes. Methods Mol Biol (2008) 1.52

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity. J Gen Virol (2013) 1.41

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A (2013) 1.41

Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN. J Immunol (2011) 1.41

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus. Arthritis Rheum (2005) 1.39

A mechanism for the inhibition of fever by a virus. Proc Natl Acad Sci U S A (1996) 1.39

Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines. J Virol (2007) 1.30

Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara. J Gen Virol (2005) 1.24

The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response. Cell Host Microbe (2011) 1.21

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J (2012) 1.14

Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol (2008) 1.13

Critical role of AIM2 in Mycobacterium tuberculosis infection. Int Immunol (2012) 1.12

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation. Trends Immunol (2013) 1.03

Subversion of cytokine networks by virally encoded decoy receptors. Immunol Rev (2012) 0.98

Bioluminescence resonance energy transfer: an emerging tool for the detection of protein-protein interaction in living cells. Methods Mol Biol (2012) 0.79

Interleukin-1β receptor expressed by modified vaccinia virus Ankara interferes with interleukin-1β activity produced in various virus-infected antigen-presenting cells. Virol J (2013) 0.77