Cardiac surgery, the brain, and inflammation.

Postoperative cognitive dysfunction: current developments in mechanism and prevention. Med Sci Monit (2014) 0.84

Hypoxemia, oxygen content, and the regulation of cerebral blood flow. Am J Physiol Regul Integr Comp Physiol (2015) 0.78

Neurological injuries and extracorporeal membrane oxygenation: the challenge of the new ECMO era. Neurol Sci (2016) 0.75

Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology (Berl) (2014) 0.75

Expression of S100β protein in patients with vascular dementia after basal ganglia hemorrhage and its clinical significance. Exp Ther Med (2017) 0.75

Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med (2001) 11.56

Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med (2002) 9.74

Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet (1998) 7.70

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 6.84

Comparing predictors of conversion and decline in mild cognitive impairment. Neurology (2010) 5.69

Monitoring brain oxygen saturation during coronary bypass surgery: a randomized, prospective study. Anesth Analg (2007) 5.26

Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology (2008) 5.15

Cognitive outcome after off-pump and on-pump coronary artery bypass graft surgery: a randomized trial. JAMA (2002) 5.06

Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Neurology (2010) 3.83

Adverse cerebral effects of anaesthesia on old people. Lancet (1955) 3.53

A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia (2012) 3.47

Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. J Gen Intern Med (1998) 3.21

Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg (2003) 2.31

Statement of consensus on assessment of neurobehavioral outcomes after cardiac surgery. Ann Thorac Surg (1995) 2.27

The impact of microemboli during cardiopulmonary bypass on neuropsychological functioning. Stroke (1994) 2.25

Intraoperative cerebral high-intensity transient signals and postoperative cognitive function: a systematic review. Am J Surg (2008) 1.92

The assessment of postoperative cognitive function. Acta Anaesthesiol Scand (2001) 1.90

Delirium: an independent predictor of functional decline after cardiac surgery. J Am Geriatr Soc (2010) 1.82

The effects of cardiopulmonary bypass on the number of cerebral microemboli and the incidence of cognitive dysfunction after coronary artery bypass graft surgery. Anesth Analg (2009) 1.74

Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth (2009) 1.72

The apolipoprotein E epsilon4 allele is not associated with cognitive dysfunction in cardiac surgery. Ann Thorac Surg (2008) 1.71

Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia. J Alzheimers Dis (2011) 1.66

Delirium after coronary artery bypass graft surgery and late mortality. Ann Neurol (2010) 1.63

Review articles: postoperative delirium: acute change with long-term implications. Anesth Analg (2011) 1.60

Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA (2012) 1.59

A prospective cohort study evaluating associations among delirium, postoperative cognitive dysfunction, and apolipoprotein E genotype following open aortic repair. Can J Anaesth (2011) 1.52

Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery. Psychosom Med (2006) 1.51

Premature death associated with delirium at 1-year follow-up. Arch Intern Med (2005) 1.48

Delirium and long-term cognitive impairment. Int Rev Psychiatry (2009) 1.38

The effects of anesthesia and elective surgery on old people. Lancet (1961) 1.30

Delirium in hospitalized older patients: recognition and risk factors. J Geriatr Psychiatry Neurol (1998) 1.28

New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol Scand (2010) 1.28

Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth Analg (2011) 1.27

Elucidating the pathophysiology of delirium and the interrelationship of delirium and dementia. J Gerontol A Biol Sci Med Sci (2006) 1.26

The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery. Anesth Analg (2002) 1.24

Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials. Eur Heart J (2008) 1.22

Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg (1999) 1.20

Meta-analysis of factors which influence delirium following cardiac surgery. J Card Surg (2012) 1.13

The cardiotomy trial: a randomized, double-blind study to assess the effect of processing of shed blood during cardiopulmonary bypass on transfusion and neurocognitive function. Circulation (2007) 1.13

Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery. Stroke (2002) 1.10

Depth of anaesthesia and post-operative cognitive dysfunction. Acta Anaesthesiol Scand (2009) 1.08

Intraoperative hyperglycemia and cognitive decline after CABG. Ann Thorac Surg (2007) 1.06

The (un)importance of cerebral microemboli. Semin Cardiothorac Vasc Anesth (2010) 1.03

The role of inflammation in the pathogenesis of delirium and dementia in older adults: a review. CNS Neurosci Ther (2010) 1.02

Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med (2012) 1.02

Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery. Stroke (2009) 1.02

Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer's disease. Anaesthesia (2010) 1.01

Measuring clinical progression in MCI and pre-MCI populations: enrichment and optimizing clinical outcomes over time. Alzheimers Res Ther (2012) 0.99

Microemboli from cardiopulmonary bypass are associated with a serum marker of brain injury. J Extra Corpor Technol (2010) 0.98

Low-dose ketamine affects immune responses in humans during the early postoperative period. Br J Anaesth (2007) 0.97

Genetic polymorphisms and the risk of stroke after cardiac surgery. Stroke (2005) 0.96

Postoperative cognitive dysfunction: toward the Alzheimer's disease pathomechanism hypothesis. J Alzheimers Dis (2010) 0.96

Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res (2011) 0.94

Neuroprotection by ketamine: a review of the experimental and clinical evidence. J Cardiothorac Vasc Anesth (2009) 0.94

Anesthesia and incident dementia: a population-based, nested, case-control study. Mayo Clin Proc (2013) 0.93

Preexisting cognitive impairment and mild cognitive impairment in subjects presenting for total hip joint replacement. Anesthesiology (2011) 0.93

Neurogenesis in the adult brain: implications for Alzheimer's disease. CNS Neurol Disord Drug Targets (2007) 0.92

Reduced cerebral oxygen saturation during thoracic surgery predicts early postoperative cognitive dysfunction. Br J Anaesth (2012) 0.91

Brain injury and neuropsychological outcome after coronary artery surgery are affected by complement activation. Ann Thorac Surg (2005) 0.90

A longitudinal study of motor subtypes in delirium: frequency and stability during episodes. J Psychosom Res (2012) 0.89

Meloxicam improves object recognition memory and modulates glial activation after splenectomy in mice. Eur J Anaesthesiol (2012) 0.88

Intravenous antiarrhythmic doses of lidocaine increase the survival rate of CA1 neurons and improve cognitive outcome after transient global cerebral ischemia in rats. Neuroscience (2011) 0.88

A comparison of the effect of high- and low-dose fentanyl on the incidence of postoperative cognitive dysfunction after coronary artery bypass surgery in the elderly. Anesthesiology (2006) 0.88

Cerebral emboli detected by transcranial Doppler during cardiopulmonary bypass are not correlated with postoperative cognitive deficits. Stroke (2010) 0.88

Cardiac surgical patients exposed to heparin-bonded circuits develop less postoperative cerebral dysfunction than patients exposed to non-heparin-bonded circuits. Perfusion (2001) 0.83

Neurological complications of coronary artery bypass graft surgery: six month follow-up study. Br Med J (Clin Res Ed) (1986) 0.82

The effects of ketamine-isomers on neuronal injury and regeneration in rat hippocampal neurons. Anesth Analg (1996) 0.82

Emboli, inflammation, and CNS impairment: an overview. Heart Surg Forum (2002) 0.81

Cognitive outcome after on- and off-pump coronary artery bypass grafting surgery: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth (2013) 0.80

Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model. J Neurochem (2011) 0.80

Why are cerebral microemboli not associated with cognitive decline? Anesth Analg (2009) 0.80

Brain emboli distribution and differentiation during cardiopulmonary bypass. J Cardiothorac Vasc Anesth (2013) 0.80

Centrifugal versus roller head pumps for cardiopulmonary bypass: effect on early neuropsychologic outcomes after coronary artery surgery. J Cardiothorac Vasc Anesth (2002) 0.79

Cognitive impairment before and six months after cardiac surgery increase mortality risk at median 11 year follow-up: a cohort study. Int J Cardiol (2013) 0.78

Heparin-bonded cardiopulmonary bypass circuits reduce cognitive dysfunction. J Cardiothorac Vasc Anesth (2002) 0.78

Postoperative neurocognitive function and microembolus detection in patients undergoing neck dissection: a pilot study. Eur J Anaesthesiol (2010) 0.78

Predictors of cognitive recovery after cardiac surgery. Anesth Analg (2013) 0.78

Successful management of excited delirium syndrome with prehospital ketamine: two case examples. Prehosp Emerg Care (2012) 0.78

Anesthesia and Alzheimer's disease: time to wake up! Int Psychogeriatr (2012) 0.77

Ketamine decreases cerebral infarct volume and improves neurological outcome following experimental head trauma in rats. J Neurosurg Anesthesiol (1992) 0.77

Do miniaturized extracorporeal circuits confer significant clinical benefit without compromising safety? A meta-analysis of randomized controlled trials. ASAIO J (2011) 0.76

The effect of etanercept on lung leukocyte margination and fibrin deposition after cardiac surgery. Am J Respir Crit Care Med (2013) 0.76

Cognitive dysfunction after off-pump versus on-pump coronary artery bypass surgery: a meta-analysis. J Int Med Res (2012) 0.76

Mini-forum: Roles of amyloid-beta and tau phosphorylation in neuronal repair and protection. J Alzheimers Dis (2009) 0.76

Lignocaine: neuro-protective or wishful thinking? J Extra Corpor Technol (2009) 0.75

DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37

Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology (2007) 6.17

Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet (2002) 5.27

Perioperative epidural analgesia and outcome after major abdominal surgery in high-risk patients. Anesth Analg (2003) 4.15

Mechanisms of action of environmental factors--tobacco smoking. J Clin Periodontol (2005) 2.96

Conducting indirect-treatment-comparison and network-meta-analysis studies: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 2. Value Health (2011) 2.88

Determining the extent of cognitive change after coronary surgery: a review of statistical procedures. Ann Thorac Surg (2002) 2.17

Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. Science (2008) 1.93

A review of neuraxial epidural morbidity: experience of more than 8,000 cases at a single teaching hospital. Anesthesiology (2007) 1.80

The apolipoprotein E epsilon4 allele is not associated with cognitive dysfunction in cardiac surgery. Ann Thorac Surg (2008) 1.71

Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial. Anesth Analg (2010) 1.62

No study left behind: a network meta-analysis in non-small-cell lung cancer demonstrating the importance of considering all relevant data. Value Health (2009) 1.61

Plasma amyloid beta42 and amyloid beta40 levels are associated with early cognitive dysfunction after cardiac surgery. Ann Thorac Surg (2009) 1.50

Preexisting cognitive impairment is associated with postoperative cognitive dysfunction after hip joint replacement surgery. Anesthesiology (2015) 1.50

The influence of different error estimates in the detection of postoperative cognitive dysfunction using reliable change indices with correction for practice effects. Arch Clin Neuropsychol (2007) 1.47

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res (2012) 1.46

Tobacco use increases susceptibility to bacterial infection. Tob Induc Dis (2008) 1.45

N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways. J Biol Chem (2006) 1.42

First hand transplant procedure in Australia: outcome at 2 years. Med J Aust (2013) 1.40

Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis. Mol Microbiol (2005) 1.38

Examination of the use of cognitive domains in postoperative cognitive dysfunction after coronary artery bypass graft surgery. Ann Thorac Surg (2005) 1.38

Preexisting cognitive impairment in patients scheduled for elective coronary artery bypass graft surgery. Anesth Analg (2007) 1.30

Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth Analg (2011) 1.27

Network meta-analysis on the log-hazard scale, combining count and hazard ratio statistics accounting for multi-arm trials: a tutorial. BMC Med Res Methodol (2010) 1.21

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron (2013) 1.21

A comparison of dexmedetomidine versus conventional therapy for sedation and hemodynamic control during carotid endarterectomy performed under regional anesthesia. Anesth Analg (2006) 1.20

Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts. J Biol Chem (2011) 1.19

Direct evidence of 1,900 years of indigenous silver production in the Lake Titicaca Basin of Southern Peru. Proc Natl Acad Sci U S A (2009) 1.17

Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response. J Bacteriol (2007) 1.17

Continuous femoral nerve blockade or epidural analgesia after total knee replacement: a prospective randomized controlled trial. Anesth Analg (2005) 1.15

Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells. Biochim Biophys Acta (2007) 1.15

Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity. PLoS One (2010) 1.10

Valuing health care using willingness to pay: a comparison of the payment card and dichotomous choice methods. J Health Econ (2004) 1.09

Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage. Proc Natl Acad Sci U S A (2010) 1.08

Tobacco smoke augments Porphyromonas gingivalis-Streptococcus gordonii biofilm formation. PLoS One (2011) 1.06

Functional specialization in proline biosynthesis of melanoma. PLoS One (2012) 1.06

Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolyzable polyphosphate. J Biol Chem (2002) 1.04

Predicting outcomes of steady-state ¹³C isotope tracing experiments using Monte Carlo sampling. BMC Syst Biol (2012) 1.02

Early cognitive impairment after sedation for colonoscopy: the effect of adding midazolam and/or fentanyl to propofol. Anesth Analg (2009) 1.02

Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma. Pigment Cell Melanoma Res (2012) 1.00

Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. Mol Immunol (2008) 0.99

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases. J Med Chem (2008) 0.98

Tobacco-induced alterations to Porphyromonas gingivalis-host interactions. Environ Microbiol (2009) 0.98

Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic (2012) 0.98

Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655. Appl Environ Microbiol (2010) 0.98

Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major. Mol Microbiol (2009) 0.97

Effects of smoking and gingival inflammation on salivary antioxidant capacity. J Clin Periodontol (2006) 0.96

Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem (2014) 0.95

Cost-effectiveness of heptavalent conjugate pneumococcal vaccine (Prevenar) in Germany: considering a high-risk population and herd immunity effects. Eur J Health Econ (2007) 0.93

Clinical and cost-effectiveness of left ventricular assist devices as destination therapy for people with end-stage heart failure: a systematic review and economic evaluation. Int J Technol Assess Health Care (2007) 0.93

Preexisting cognitive impairment and mild cognitive impairment in subjects presenting for total hip joint replacement. Anesthesiology (2011) 0.93

The effectiveness and cost-effectiveness of treatments for idiopathic pulmonary fibrosis: systematic review, network meta-analysis and health economic evaluation. BMC Pharmacol Toxicol (2014) 0.92

How far do you go? Efficient searching for indirect evidence. Med Decis Making (2009) 0.92

The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells. J Immunol (2013) 0.91

Tagaturonate-fructuronate epimerase UxaE, a novel enzyme in the hexuronate catabolic network in Thermotoga maritima. Environ Microbiol (2012) 0.91

Concurrent validity of written and OSCE components of the Canadian dental certification examinations. J Dent Educ (2003) 0.90

Biomolecular characterisation of leucocytes by infrared spectroscopy. Br J Haematol (2007) 0.90

Cost-effectiveness of left ventricular-assist devices in end-stage heart failure. Expert Rev Cardiovasc Ther (2008) 0.89

A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution. Nat Protoc (2011) 0.89

Salivary antioxidants in patients with type 1 or 2 diabetes and inflammatory periodontal disease: a case-control study. J Periodontol (2009) 0.89

The metabolic origins of mannose in glycoproteins. J Biol Chem (2014) 0.89

The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release. BMC Cell Biol (2008) 0.88

A comparison of the effect of high- and low-dose fentanyl on the incidence of postoperative cognitive dysfunction after coronary artery bypass surgery in the elderly. Anesthesiology (2006) 0.88

Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence. J Biol Chem (2006) 0.87

Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: rationale and design. Am Heart J (2009) 0.87

The slow axonal transport of alpha-synuclein--mechanistic commonalities amongst diverse cytosolic cargoes. Cytoskeleton (Hoboken) (2012) 0.87

Cognitive decline in the elderly: is anaesthesia implicated? Best Pract Res Clin Anaesthesiol (2011) 0.85

Modeling payback from research into the efficacy of left-ventricular assist devices as destination therapy. Int J Technol Assess Health Care (2007) 0.85

A proton pumping pyrophosphatase in the Golgi apparatus and plasma membrane vesicles of Trypanosoma cruzi. Mol Biochem Parasitol (2002) 0.84

Anesthesiology must play a greater role in patients with Alzheimer's disease. Anesth Analg (2011) 0.84

Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitis. J Periodontol (2013) 0.83

Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria. MBio (2014) 0.83

Bilateral vocal cord palsy during carotid endarterectomy under cervical plexus block. Anesth Analg (2006) 0.82

Trypanosoma cruzi H+-ATPase 1 (TcHA1) and 2 (TcHA2) genes complement yeast mutants defective in H+ pumps and encode plasma membrane P-type H+-ATPases with different enzymatic properties. J Biol Chem (2002) 0.82

Epidural anesthesia for coronary artery bypass surgery compared with general anesthesia alone does not reduce biochemical markers of myocardial damage. Anesth Analg (2005) 0.82

Major bleeding rates after prophylaxis against venous thromboembolism: systematic review, meta-analysis, and cost implications. Int J Technol Assess Health Care (2004) 0.82

Postoperative cognitive dysfunction and aortic atheroma. Ann Thorac Surg (2010) 0.82

EVEREST II high risk study based UK cost-effectiveness analysis of MitraClip® in patients with severe mitral regurgitation ineligible for conventional repair/replacement surgery. J Med Econ (2013) 0.81

Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice. FASEB J (2014) 0.81

Is fast-track cardiac anesthesia now the global standard of care? Anesth Analg (2009) 0.81

Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice. Mol Med (2012) 0.81

Carbon dioxide field flooding versus mechanical de-airing during open-heart surgery: a prospective randomized controlled trial. Perfusion (2003) 0.80

Detection of postoperative cognitive decline after coronary artery bypass graft surgery is affected by the number of neuropsychological tests in the assessment battery. Ann Thorac Surg (2006) 0.80

Progression of periodontal disease in a maintenance population of smokers and non-smokers: a 3-year longitudinal study. J Periodontol (2008) 0.80

The importance of baseline viral load when assessing relative efficacy in treatment-naïve HBeAg-positive chronic hepatitis B: a systematic review and network meta-analysis. Syst Rev (2014) 0.80

Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells. Tob Induc Dis (2012) 0.79

Cost-effectiveness of low-level heat wrap therapy for low back pain. Value Health (2004) 0.79

Centrifugal versus roller head pumps for cardiopulmonary bypass: effect on early neuropsychologic outcomes after coronary artery surgery. J Cardiothorac Vasc Anesth (2002) 0.79

Synergy between intrathecal omega-conotoxin CVID and dexmedetomidine to attenuate mechanical hypersensitivity in the rat. Eur J Pharmacol (2004) 0.78

Overexpression of the Leishmania amazonensis Ca2+-ATPase gene lmaa1 enhances virulence. Cell Microbiol (2002) 0.78

The influence of different error estimates in the detection of post-operative cognitive dysfunction using reliable change indices with correction for practice effects. Arch Clin Neuropsychol (2006) 0.78