Published in J Gerontol A Biol Sci Med Sci on December 01, 2006
Cognitive impairment in the aging dialysis and chronic kidney disease populations: an occult burden. Adv Chronic Kidney Dis (2008) 1.98
Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence. J Gerontol A Biol Sci Med Sci (2008) 1.61
The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*. Crit Care Med (2012) 1.51
Insulin-like growth factor-1 and delirium in critically ill mechanically ventilated patients: a preliminary investigation. Int Psychogeriatr (2011) 1.44
Predisposing factors for postoperative delirium after hip fracture repair in individuals with and without dementia. J Am Geriatr Soc (2011) 1.26
White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults. J Am Geriatr Soc (2010) 1.16
Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive Care Med (2009) 1.06
Measures of executive function and depression identify patients at risk for postoperative delirium. Anesthesiology (2009) 1.06
The neuroinflammatory response of postoperative cognitive decline. Br Med Bull (2013) 1.01
Improving delirium care in the intensive care unit: the design of a pragmatic study. Trials (2011) 0.96
Study protocol for the recreational stimulation for elders as a vehicle to resolve delirium superimposed on dementia (Reserve For DSD) trial. Trials (2011) 0.89
Screening for delirium using family caregivers: convergent validity of the Family Confusion Assessment Method and interviewer-rated Confusion Assessment Method. J Am Geriatr Soc (2012) 0.88
Design and methods of the Hospital Elder Life Program (HELP), a multicomponent targeted intervention to prevent delirium in hospitalized older patients: efficacy and cost-effectiveness in Dutch health care. BMC Geriatr (2013) 0.88
Cardiac surgery, the brain, and inflammation. J Extra Corpor Technol (2014) 0.88
An inpatient rehabilitation model of care targeting patients with cognitive impairment. BMC Geriatr (2012) 0.80
Vitamin D and delirium in critically ill patients: a preliminary investigation. J Crit Care (2012) 0.79
Gender differences in factors associated with delirium severity in older adults with dementia. Arch Psychiatr Nurs (2014) 0.77
Pathogenesis and treatment of post-operative cognitive dysfunction. Electron Physician (2017) 0.75
A year of excellence in geriatric research and some new dishes on the menu. J Gerontol A Biol Sci Med Sci (2007) 0.75
Licensed Nurse and Nursing Assistant Recognition of Delirium in Nursing Home Residents With Dementia. Ann Longterm Care (2015) 0.75
NeurimmiRs and Postoperative Delirium in Elderly Patients Undergoing Total Hip/Knee Replacement: A Pilot Study. Front Aging Neurosci (2017) 0.75
The plasma levels of brain-derived neurotrophic factor are positively associated with emergence agitation in the elderly after gastrointestinal surgery. J Anesth (2016) 0.75
Perioperative Management of Neurological Conditions. Health Serv Insights (2017) 0.75
A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med (1999) 11.80
Delirium in older persons. N Engl J Med (2006) 9.70
Delirium. The occurrence and persistence of symptoms among elderly hospitalized patients. Arch Intern Med (1992) 2.92
Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc (2000) 2.89
The association between delirium and cognitive decline: a review of the empirical literature. Neuropsychol Rev (2004) 2.72
The reversible dementias: do they reverse? Ann Intern Med (1988) 2.46
Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care. Am J Med (1999) 2.01
Delirium in elderly patients. Am J Geriatr Psychiatry (2004) 1.84
Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci (2006) 1.83
The course of delirium in older medical inpatients: a prospective study. J Gen Intern Med (2003) 1.82
The prognostic significance of subsyndromal delirium in elderly medical inpatients. J Am Geriatr Soc (2003) 1.66
Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci (2006) 1.45
The occurrence and duration of symptoms in elderly patients with delirium. J Gerontol (1993) 1.39
Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. J Gerontol A Biol Sci Med Sci (2006) 1.32
Regional cerebral blood flow in delirium patients. Psychiatry Clin Neurosci (2003) 1.12
Does educational attainment contribute to risk for delirium? A potential role for cognitive reserve. J Gerontol A Biol Sci Med Sci (2006) 1.07
Do delirium and Alzheimer's dementia share specific pathogenetic mechanisms? Dement Geriatr Cogn Disord (1999) 1.03
The role of neuroimaging in elucidating delirium pathophysiology. J Gerontol A Biol Sci Med Sci (2006) 1.02
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Gait speed and survival in older adults. JAMA (2011) 15.01
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci (2004) 12.46
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci (2006) 8.00
Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc (2006) 6.81
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curability. J Natl Cancer Inst (2006) 6.02
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood (2004) 5.86
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985) (2003) 5.73
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med (2010) 5.20
Frailty: an emerging research and clinical paradigm--issues and controversies. J Gerontol A Biol Sci Med Sci (2007) 4.98
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
Hearing loss and incident dementia. Arch Neurol (2011) 4.65
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms. JAMA (2004) 4.27
Hearing loss and cognitive decline in older adults. JAMA Intern Med (2013) 4.25
Hearing loss prevalence in the United States. Arch Intern Med (2011) 4.22
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci (2004) 3.96
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med (2009) 3.71
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
Hearing loss prevalence and risk factors among older adults in the United States. J Gerontol A Biol Sci Med Sci (2011) 3.63
Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care (2008) 3.54
Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc (2004) 3.48
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc (2003) 3.30
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21
Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci (2009) 3.14
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA (2012) 3.10
Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals. JAMA Intern Med (2013) 3.08
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Hypercortisolemic depression is associated with the metabolic syndrome in late-life. Psychoneuroendocrinology (2007) 2.98
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. Arch Intern Med (2007) 2.88
Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci (2006) 2.85
The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci (2014) 2.84
Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci (2012) 2.82
Uric acid and inflammatory markers. Eur Heart J (2006) 2.81
Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry (2003) 2.77
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Executive function correlates with walking speed in older persons: the InCHIANTI study. J Am Geriatr Soc (2005) 2.75
Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol (2008) 2.75
Physical performance in peripheral arterial disease: a slower rate of decline in patients who walk more. Ann Intern Med (2006) 2.73
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
Measures of physical performance and risk for progressive and catastrophic disability: results from the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci (2005) 2.59
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet (2009) 2.58
Hearing loss and cognition in the Baltimore Longitudinal Study of Aging. Neuropsychology (2011) 2.54
Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol (1985) (2006) 2.50
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet (2006) 2.44
Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging. Neuroepidemiology (2010) 2.39
Associations of borderline and low normal ankle-brachial index values with functional decline at 5-year follow-up: the WALCS (Walking and Leg Circulation Study). J Am Coll Cardiol (2009) 2.37
A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more? J Gerontol A Biol Sci Med Sci (2003) 2.36
Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc (2011) 2.34
Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies. Ann Intern Med (2008) 2.33
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet (2011) 2.33
Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci (2009) 2.32
Hemoglobin levels and skeletal muscle: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci (2004) 2.28
Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study. Clin Endocrinol (Oxf) (2010) 2.24
Personality predictors of longevity: activity, emotional stability, and conscientiousness. Psychosom Med (2008) 2.19
From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ (2005) 2.19
Assessing the building blocks of function: utilizing measures of functional limitation. Am J Prev Med (2003) 2.18
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med (2013) 2.18
What constitutes normal hemoglobin concentration in community-dwelling disabled older women? J Am Geriatr Soc (2004) 2.18
Metabolic factors associated with benign prostatic hyperplasia. J Clin Endocrinol Metab (2006) 2.17
A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16
Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging. Hypertension (2013) 2.15
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care (2010) 2.14
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Methodology, design, and analytic techniques to address measurement of comorbid disease. J Gerontol A Biol Sci Med Sci (2007) 2.12
Thyroid status and 6-year mortality in elderly people living in a mildly iodine-deficient area: the aging in the Chianti Area Study. J Am Geriatr Soc (2013) 2.10
Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab (2003) 2.09
Should prostate specific antigen be adjusted for body mass index? Data from the Baltimore Longitudinal Study of Aging. J Urol (2009) 2.09
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women's Health and Aging Studies I and II. J Gerontol A Biol Sci Med Sci (2005) 2.08
Report of the national institute on aging task force on comorbidity. J Gerontol A Biol Sci Med Sci (2007) 2.06