Published in PLoS Biol on April 29, 2014
Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. Proc Natl Acad Sci U S A (2015) 1.07
Lytic Cycle of Toxoplasma gondii: 15 Years Later. Annu Rev Microbiol (2015) 0.88
Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System. MBio (2015) 0.87
An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell. Elife (2015) 0.84
Calcium Signaling throughout the Toxoplasma gondii Lytic Cycle: A STUDY USING GENETICALLY ENCODED CALCIUM INDICATORS. J Biol Chem (2015) 0.83
A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. MBio (2016) 0.81
Dense granule trafficking in Toxoplasma gondii requires a unique class 27 myosin and actin filaments. Mol Biol Cell (2016) 0.79
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity. PLoS Genet (2016) 0.79
Microsporidia: Why Make Nucleotides if You Can Steal Them? PLoS Pathog (2016) 0.79
Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles. Eukaryot Cell (2015) 0.78
Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis? Parasite Immunol (2015) 0.78
In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis. MBio (2016) 0.76
MAF1 sequesters mitochondria for Toxoplasma gondii. PLoS Biol (2014) 0.75
Host Mitochondrial Association Evolved in the Human Parasite Toxoplasma gondii via Neofunctionalization of a Gene Duplicate. Genetics (2016) 0.75
Pyrimidine Pathway-Dependent and -Independent Functions of the Toxoplasma gondii Mitochondrial Dihydroorotate Dehydrogenase. Infect Immun (2016) 0.75
Toxoplasma gondii MAF1b Binds the Host Cell MIB Complex To Mediate Mitochondrial Association. mSphere (2017) 0.75
Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii. PLoS Pathog (2017) 0.75
The Sequence Alignment/Map format and SAMtools. Bioinformatics (2009) 232.39
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
BLAT--the BLAST-like alignment tool. Genome Res (2002) 126.78
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics (2010) 53.23
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. J Exp Med (1972) 8.66
Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell (2010) 8.29
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med (1983) 7.65
Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease. J Infect Dis (1995) 6.79
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell (2002) 5.45
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature (2006) 4.50
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science (2006) 4.44
Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science (2006) 4.23
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation. J Biol Chem (1996) 4.06
Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31
Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries. Science (2001) 3.21
Poxviruses deploy genomic accordions to adapt rapidly against host antiviral defenses. Cell (2012) 2.94
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J Exp Med (2011) 2.87
Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space. Cell (2006) 2.79
Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion. Cell Host Microbe (2008) 2.66
Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii. Nucleic Acids Res (2005) 2.64
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe (2010) 2.57
Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol (2005) 2.37
Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. J Immunol (2004) 2.35
A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis. J Leukoc Biol (2003) 2.29
Mitofusin 2 inhibits mitochondrial antiviral signaling. Sci Signal (2009) 2.25
The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries. Cell Host Microbe (2011) 2.25
Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. Infect Immun (2005) 2.21
Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat Rev Microbiol (2012) 2.18
Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction. J Cell Sci (1997) 2.16
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc Natl Acad Sci U S A (2011) 2.13
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J Exp Med (2009) 2.11
The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum. Appl Environ Microbiol (1996) 2.04
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A (2011) 2.02
Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii. Genetics (1992) 2.01
Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway. EMBO Rep (2009) 1.97
From protozoa to mammalian cells: a new paradigm in the life cycle of intracellular bacterial pathogens. Environ Microbiol (2000) 1.93
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. J Biol Chem (2010) 1.87
The Toxoplasma gondii protein ROP2 mediates host organelle association with the parasitophorous vacuole membrane. J Cell Biol (2001) 1.69
Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. PLoS Pathog (2010) 1.66
Migration of Toxoplasma gondii across biological barriers. Trends Microbiol (2003) 1.61
Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep (2010) 1.61
Morphological studies of the association of mitochondria with chlamydial inclusions and the fusion of chlamydial inclusions. J Electron Microsc (Tokyo) (1991) 1.54
The role of mitochondria in cellular defense against microbial infection. Semin Immunol (2009) 1.52
Prediction of mitochondrial proteins using support vector machine and hidden Markov model. J Biol Chem (2005) 1.42
Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast. EMBO J (2006) 1.42
The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins. J Biol Chem (2005) 1.40
Mitochondria in innate immunity. EMBO Rep (2011) 1.31
Toxoplasma gondii: purine synthesis and salvage in mutant host cells and parasites. Exp Parasitol (1982) 1.27
Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages. J Immunol (2006) 1.26
Toxoplasma gondii: genetic recombination between drug resistant mutants. Exp Parasitol (1980) 1.25
Biochemical and structural characterization of the paralogous benzoate CoA ligases from Burkholderia xenovorans LB400: defining the entry point into the novel benzoate oxidation (box) pathway. J Mol Biol (2007) 1.20
Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii. Infect Immun (2007) 1.18
Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death. Proc Natl Acad Sci U S A (2011) 1.08
The DNA helicase, Hmi1p, is transported into mitochondria by a C-terminal cleavable targeting signal. J Biol Chem (1999) 1.05
Keeping mitochondria in shape: a matter of life and death. Eur J Clin Invest (2013) 1.04
Infection of murine peritoneal macrophages with Toxoplasma gondii exposed to ultraviolet light. Z Parasitenkd (1981) 1.03
Calcium and mitochondria: mechanisms and functions of a troubled relationship. Biochim Biophys Acta (2004) 1.00
Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. Eukaryot Cell (2008) 0.98
Mitochondria and viruses. Mitochondrion (2010) 0.98
A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites. PLoS Pathog (2013) 0.96
Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8. Int J Parasitol (2010) 0.89
Small variant surface antigens and Plasmodium evasion of immunity. Future Microbiol (2010) 0.85