Published in Trends Genet on May 01, 2014
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. Cancer Cell (2015) 1.47
DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal. Nucleic Acids Res (2014) 1.34
BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Mol Cell (2015) 1.12
RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells. Nat Commun (2014) 1.07
The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability. Front Genet (2015) 0.98
Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1). J Biol Chem (2014) 0.84
End of the beginning: elongation and termination features of alternative modes of chromosomal replication initiation in bacteria. PLoS Genet (2015) 0.83
Intron Invasions Trace Algal Speciation and Reveal Nearly Identical Arctic and Antarctic Micromonas Populations. Mol Biol Evol (2015) 0.83
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences. Nucleic Acids Res (2016) 0.81
hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes. Oncogene (2015) 0.79
Nascent Connections: R-Loops and Chromatin Patterning. Trends Genet (2016) 0.78
RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome. Adv Immunol (2015) 0.78
Evolution of the Antisense Overlap between Genes for Thyroid Hormone Receptor and Rev-erbα and Characterization of an Exonic G-Rich Element That Regulates Splicing of TRα2 mRNA. PLoS One (2015) 0.78
Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability. Trends Genet (2017) 0.77
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression. Genes (Basel) (2017) 0.77
The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA. J Biol Chem (2016) 0.77
Identification of Multiple Proteins Coupling Transcriptional Gene Silencing to Genome Stability in Arabidopsis thaliana. PLoS Genet (2016) 0.77
Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability. J Mol Biol (2016) 0.77
RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression. J Biol Chem (2015) 0.77
The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast. Nucleic Acids Res (2015) 0.76
Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep (2016) 0.75
Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. Genome Biol (2016) 0.75
BPTF Is Essential for T Cell Homeostasis and Function. J Immunol (2016) 0.75
RNA Binding Proteins and Genome Integrity. Int J Mol Sci (2017) 0.75
Genome Instability and γH2AX. Int J Mol Sci (2017) 0.75
Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell (2012) 11.69
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med (2003) 11.17
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Lessons from the cancer genome. Cell (2013) 8.12
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature (2012) 8.03
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med (2011) 7.89
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
Exploring the genomes of cancer cells: progress and promise. Science (2011) 6.16
Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol Cell (2003) 5.48
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet (2006) 5.26
DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19
APOBEC3B is an enzymatic source of mutation in breast cancer. Nature (2013) 5.18
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell (2005) 4.91
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev (2010) 4.75
Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61
Regulatory roles of natural antisense transcripts. Nat Rev Mol Cell Biol (2009) 4.48
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell (2009) 4.17
R loops: from transcription byproducts to threats to genome stability. Mol Cell (2012) 3.71
R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters. Mol Cell (2012) 3.56
Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol (2002) 3.18
Replication stress links structural and numerical cancer chromosomal instability. Nature (2013) 3.11
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol Cell (2011) 3.02
Transcriptional regulation and its misregulation in disease. Cell (2013) 2.92
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes. Mol Cell (2011) 2.66
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet (2012) 2.64
The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J (2002) 2.62
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol (2009) 2.60
Yeast Sen1 helicase protects the genome from transcription-associated instability. Mol Cell (2011) 2.59
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol (2012) 2.51
RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Mol Cell (2011) 2.48
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes Dev (2011) 2.45
Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev (2010) 2.44
The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol Cell (2008) 2.36
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma. Nat Genet (2013) 2.20
R loops are linked to histone H3 S10 phosphorylation and chromatin condensation. Mol Cell (2013) 1.95
Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence. Nat Struct Mol Biol (2013) 1.95
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev (2005) 1.93
R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes Dev (2011) 1.82
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. Mol Cell Biol (2006) 1.73
Lsm1 promotes genomic stability by controlling histone mRNA decay. EMBO J (2011) 1.73
Interdependence between transcription and mRNP processing and export, and its impact on genetic stability. Mol Cell (2005) 1.72
GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination. Genome Res (2013) 1.71
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants. Genes Dev (2012) 1.69
SF3B1 mutations are associated with alternative splicing in uveal melanoma. Cancer Discov (2013) 1.68
Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. Nat Genet (2012) 1.61
Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem (2003) 1.60
The yeast SEN1 gene is required for the processing of diverse RNA classes. Nucleic Acids Res (1997) 1.55
Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell (2012) 1.51
Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J (2011) 1.49
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet (2011) 1.41
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genet (2011) 1.41
The homologous recombination machinery modulates the formation of RNA-DNA hybrids and associated chromosome instability. Elife (2013) 1.40
The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. PLoS One (2012) 1.38
Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance. Am J Hematol (2013) 1.35
Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip. PLoS Genet (2014) 1.30
Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Hum Mol Genet (2009) 1.30
Contribution of Trf4/5 and the nuclear exosome to genome stability through regulation of histone mRNA levels in Saccharomyces cerevisiae. Genetics (2006) 1.30
RNA polymerase II collision interrupts convergent transcription. Mol Cell (2012) 1.28
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol (2012) 1.27
Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nat Rev Cancer (2013) 1.26
DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation. Genes Cells (2012) 1.26
R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. Proc Natl Acad Sci U S A (2013) 1.23
Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. PLoS Genet (2012) 1.21
The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion. Nucleic Acids Res (2010) 1.12
The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers. J Pathol (2013) 1.12
The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening. EMBO J (2013) 1.07
Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res (2012) 1.06
Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer. Cancer Res (2012) 1.04
Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet (2013) 1.03
The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability. Genes Dev (2013) 1.03
Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis. Biochim Biophys Acta (2012) 0.96
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. Proc Natl Acad Sci U S A (2012) 0.96
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. Genes Dev (2013) 0.93
R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity. PLoS One (2013) 0.92
Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway. PLoS Genet (2008) 0.92
Cyclins and cell cycle control in cancer and disease. Genes Cancer (2012) 0.90
Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma. Neoplasia (2012) 0.89
Pronounced and extensive microtubule defects in a Saccharomyces cerevisiae DIS3 mutant. Yeast (2011) 0.84
Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae. PLoS One (2013) 0.81