Published in Nature on February 28, 2013
The causes and consequences of genetic heterogeneity in cancer evolution. Nature (2013) 5.91
Causes and consequences of replication stress. Nat Cell Biol (2014) 3.70
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. Nat Cell Biol (2014) 1.86
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy. Cancer Discov (2015) 1.76
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov (2014) 1.69
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene (2015) 1.65
Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition. Ann Oncol (2014) 1.64
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol (2014) 1.62
The mitotic origin of chromosomal instability. Curr Biol (2014) 1.60
Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Mol Cell (2014) 1.58
Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. JAMA Oncol (2016) 1.51
Cell Fusion Connects Oncogenesis with Tumor Evolution. Am J Pathol (2015) 1.44
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science (2016) 1.40
A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming. Cell (2016) 1.38
Tracking genomic cancer evolution for precision medicine: the lung TRACERx study. PLoS Biol (2014) 1.34
Whole chromosome gain does not in itself confer cancer-like chromosomal instability. Proc Natl Acad Sci U S A (2013) 1.34
Replication stress and cancer: it takes two to tango. Exp Cell Res (2014) 1.33
Exploiting replicative stress to treat cancer. Nat Rev Drug Discov (2015) 1.27
How unfinished business from S-phase affects mitosis and beyond. EMBO J (2013) 1.26
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer. Cell Stem Cell (2015) 1.11
APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity. Cancer Discov (2015) 1.10
DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Res (2013) 1.09
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos. Cell Div (2015) 1.07
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Cell Death Differ (2013) 1.06
Unique features of the transcriptional response to model aneuploidy in human cells. BMC Genomics (2014) 1.06
Mechanisms of genome instability induced by RNA-processing defects. Trends Genet (2014) 1.04
Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX. Nat Commun (2015) 1.03
Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma. Cancer Discov (2015) 1.01
A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability. Front Oncol (2013) 1.00
Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions. Am J Gastroenterol (2014) 0.98
Genomic instability and colon carcinogenesis: from the perspective of genes. Front Oncol (2013) 0.97
Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell (2013) 0.96
The presence of extra chromosomes leads to genomic instability. Nat Commun (2016) 0.95
DNA-damage response during mitosis induces whole-chromosome missegregation. Cancer Discov (2014) 0.95
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc Natl Acad Sci U S A (2014) 0.95
RB1: a prototype tumor suppressor and an enigma. Genes Dev (2016) 0.93
Regulation and roles of Cdc7 kinase under replication stress. Cell Cycle (2014) 0.92
Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability. Front Genet (2015) 0.90
Cancer karyotypes: survival of the fittest. Front Oncol (2013) 0.90
Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum. Cell Rep (2015) 0.90
Taxane benefit in breast cancer--a role for grade and chromosomal stability. Nat Rev Clin Oncol (2013) 0.89
Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast. Mol Biol Cell (2015) 0.89
RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene (2015) 0.89
Cyclin E deregulation promotes loss of specific genomic regions. Curr Biol (2015) 0.88
The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia. Dis Model Mech (2014) 0.88
Multi-layered cancer chromosomal instability phenotype. Front Oncol (2013) 0.88
Oncogenes create a unique landscape of fragile sites. Nat Commun (2015) 0.87
MCM10: one tool for all-Integrity, maintenance and damage control. Semin Cell Dev Biol (2014) 0.87
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy. Mol Cell Oncol (2015) 0.86
Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells. Proc Natl Acad Sci U S A (2013) 0.85
The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress. Nat Cell Biol (2016) 0.85
Replication stress in Mammalian cells and its consequences for mitosis. Genes (Basel) (2015) 0.85
Increased global transcription activity as a mechanism of replication stress in cancer. Nat Commun (2016) 0.84
Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion. EMBO J (2015) 0.84
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun (2016) 0.84
Characterization at nucleotide resolution of the homogeneously staining region sites of insertion in two cancer cell lines. Nucleic Acids Res (2013) 0.84
MYC and the control of DNA replication. Cold Spring Harb Perspect Med (2014) 0.84
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. Cell Death Differ (2014) 0.83
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. Nucleic Acids Res (2015) 0.83
Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nat Commun (2015) 0.83
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. Genome Biol (2016) 0.83
Synthetic genetic targeting of genome instability in cancer. Cancers (Basel) (2013) 0.83
Tumour Cell Heterogeneity. F1000Res (2016) 0.83
Challenges of deciphering gastric cancer heterogeneity. World J Gastroenterol (2015) 0.82
The CINs of the centromere. Biochem Soc Trans (2013) 0.82
Parkin and mitophagy in cancer. Oncogene (2016) 0.81
Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen. J Virol (2013) 0.81
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle (2014) 0.81
Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability. Stem Cell Reports (2016) 0.81
Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition. Front Biol (Beijing) (2014) 0.81
The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription. EMBO Rep (2014) 0.80
Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements. Nat Commun (2015) 0.80
Fos-dependent induction of Chk1 protects osteoblasts from replication stress. Cell Cycle (2014) 0.80
Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia. Cancers (Basel) (2013) 0.80
JNK signaling is needed to tolerate chromosomal instability. Cell Cycle (2013) 0.80
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer. Cancer Cell (2017) 0.79
Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs. Biomark Res (2015) 0.79
Aurea mediocritas: the importance of a balanced genome. Cold Spring Harb Perspect Biol (2014) 0.79
Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction. Mutat Res (2014) 0.79
Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment. Nucleic Acids Res (2016) 0.78
Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation. EMBO Rep (2015) 0.78
Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll. Oncotarget (2015) 0.78
The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress. Nucleic Acids Res (2014) 0.78
Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression. EMBO Rep (2016) 0.78
Chromosomal instability, aneuploidy, and cancer. Front Oncol (2014) 0.78
MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. J Pathol (2016) 0.77
Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer. Cancer Res (2014) 0.77
p21 shapes cancer evolution. Nat Cell Biol (2016) 0.77
The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. Oncogene (2015) 0.77
Patterns of Chromosomal Aberrations in Solid Tumors. Recent Results Cancer Res (2015) 0.77
Reliable FASP-based procedures for optimal quantitative proteomic and phosphoproteomic analysis on samples from acute myeloid leukemia patients. Biol Proced Online (2016) 0.77
BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity. Nat Commun (2016) 0.77
Protective role for lipid modifications of Src-family kinases against chromosome missegregation. Sci Rep (2016) 0.77
Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal Carcinomas. Gastroenterology (2015) 0.77
A population genetics perspective on the determinants of intra-tumor heterogeneity. Biochim Biophys Acta (2017) 0.76
Molecular mechanisms involved in initiation of the DNA damage response. Mol Cell Oncol (2015) 0.76
CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis. Hum Mol Genet (2014) 0.76
Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity. G3 (Bethesda) (2015) 0.76
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med (2012) 44.56
Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13
Genetic instabilities in human cancers. Nature (1998) 22.76
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A (2007) 18.83
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33
An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60
BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis. Bioinformatics (2005) 9.84
DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19
Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol (2008) 4.95
Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell (2011) 4.83
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer. Genome Biol (2007) 4.70
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57
PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data. Biostatistics (2009) 4.31
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol (2009) 4.15
Chromosomal instability confers intrinsic multidrug resistance. Cancer Res (2011) 3.70
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (2011) 3.29
Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays. Genome Biol (2009) 2.88
Cancer chromosomal instability: therapeutic and diagnostic challenges. EMBO Rep (2012) 2.28
Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18
A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. Nat Methods (2012) 2.13
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat Struct Mol Biol (2009) 2.08
Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res (2002) 1.86
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology (2010) 1.83
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol Cell (2011) 1.77
Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia. Gastroenterology (2008) 1.47
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress. Mol Oncol (2011) 1.26
On the origins of ultra-fine anaphase bridges. Cell Cycle (2009) 1.21
Chromosomes and cancer cells. Chromosome Res (2011) 1.21
Classification of chromosome segregation errors in cancer. Chromosoma (2008) 1.17
Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage. J Mol Biol (2010) 1.16
Refining molecular analysis in the pathways of colorectal carcinogenesis. Clin Gastroenterol Hepatol (2005) 1.14
Whole chromosome loss is promoted by telomere dysfunction in primary cells. Genes Chromosomes Cancer (2010) 1.13
Approximate p-values for local sequence alignments: numerical studies. J Comput Biol (2001) 1.11
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS One (2010) 1.10
Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res (2006) 1.09
Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. Am J Gastroenterol (2000) 1.00
DNA copy number alterations correlate with survival of esophageal adenocarcinoma patients. Mod Pathol (2008) 0.91
Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies. FEBS J (2015) 0.87
PrimPol breaks replication barriers. Nat Struct Mol Biol (2013) 0.84
Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice. Curr Opin Oncol (2013) 0.84
Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol (2017) 0.83
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nat Med (2017) 0.81
Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry. DNA Repair (Amst) (2015) 0.78
Production, Purification, and Characterization of (15)N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements. Methods Enzymol (2015) 0.75
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget (2015) 0.75
With me or against me: Tumor suppressor and drug resistance activities of SAMHD1. Exp Hematol (2017) 0.75