Published in Nat Commun on May 06, 2014
High Content Imaging (HCI) on Miniaturized Three-Dimensional (3D) Cell Cultures. Biosensors (Basel) (2015) 0.77
Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays. Biomed Res Int (2017) 0.76
Biocompatible Hydrogels for Microarray Cell Printing and Encapsulation. Biosensors (Basel) (2015) 0.75
Engineered Liver Platforms for Different Phases of Drug Development. Trends Biotechnol (2016) 0.75
High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform. Stem Cell Reports (2016) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Microarrays of cells expressing defined cDNAs. Nature (2001) 5.05
Acetaminophen-induced hepatotoxicity. Drug Metab Dispos (2003) 3.22
In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci (2005) 2.89
Microarrays of lentiviruses for gene function screens in immortalized and primary cells. Nat Methods (2006) 2.18
Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J (2006) 2.13
Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma. Clin Pharmacol Ther (2011) 1.98
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology (2011) 1.86
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc Natl Acad Sci U S A (1993) 1.71
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos (2003) 1.66
The role of metabolic activation in drug-induced hepatotoxicity. Annu Rev Pharmacol Toxicol (2005) 1.65
Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events. Hepatology (2010) 1.58
Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics (2011) 1.53
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicol Appl Pharmacol (2003) 1.49
Managing the challenge of chemically reactive metabolites in drug development. Nat Rev Drug Discov (2011) 1.45
Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol (2012) 1.31
Cell lines: a tool for in vitro drug metabolism studies. Curr Drug Metab (2008) 1.30
The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver. Br J Clin Pharmacol (2002) 1.28
Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes. Drug Metab Dispos (2010) 1.27
Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. Curr Drug Metab (2004) 1.22
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica (2009) 1.21
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. Hepatology (2008) 1.13
Mechanisms of troglitazone hepatotoxicity. Chem Res Toxicol (2003) 1.10
On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins. Anal Chem (2008) 1.06
Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. Chem Res Toxicol (1998) 1.05
Reduction of toxic metabolite formation of acetaminophen. Biochem Biophys Res Commun (2002) 1.04
New technologies and screening strategies for hepatotoxicity: use of in vitro models. Toxicol Pathol (2005) 1.02
Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants. Breast Cancer Res (2006) 1.02
3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies. Toxicol Sci (2013) 1.01
Pharmacogenomics of tamoxifen: roles of drug metabolizing enzymes and transporters. Drug Metab Pharmacokinet (2011) 0.99
3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies. Toxicol In Vitro (2013) 0.99
Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos (1997) 0.98
Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos (2000) 0.97
Site-specific gene targeting for gene expression in eukaryotes. Curr Opin Biotechnol (2000) 0.97
High-throughput human metabolism and toxicity analysis. Curr Opin Biotechnol (2006) 0.93
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved. Arch Toxicol (2013) 0.88
Pharmacogenomics: out of the lab and into the community. Trends Biotechnol (2001) 0.87
Cell based approaches for evaluation of drug-induced liver injury. Toxicology (2009) 0.87
Epigenetic effects on transgene expression. Methods Mol Biol (2001) 0.85
Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity. Cell Biol Toxicol (2007) 0.83
Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites. Chem Res Toxicol (2007) 0.81
Metabolism of trifluoperazine, fluphenazine, prochlorperazine and perphenazine in rats: in vitro and urinary metabolites. Biochem Pharmacol (1974) 0.79
Bioactivation of flutamide metabolites by human liver microsomes. Drug Metab Dispos (2008) 0.79
Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity. Drug Metab Dispos (2012) 0.77
Heterologous co-expression of human cytochrome P450 1A2 and polymorphic forms of N-acetyltransferase 2 for studies on aromatic amines in V79 Chinese hamster cells. Altern Lab Anim (2005) 0.77