Published in Drug Metab Dispos on November 01, 1997
Cancer treatment and pharmacogenetics of cytochrome P450 enzymes. Invest New Drugs (2005) 1.09
Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Breast Cancer Res (2008) 1.01
Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase. Chem Res Toxicol (2008) 0.86
Hormones and the neuromuscular control of courtship in the golden-collared manakin (Manacus vitellinus). Front Neuroendocrinol (2013) 0.86
Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-á-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2. Endocrinology (2008) 0.85
Cytochrome P450-activated prodrugs. Future Med Chem (2013) 0.82
High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening. Nat Commun (2014) 0.79
A Simple, Fast, Low Cost, HPLC/UV Validated Method for Determination of Flutamide: Application to Protein Binding Studies. Adv Pharm Bull (2016) 0.79
Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice. J Gastroenterol (2006) 0.77
The androgen receptor as an emerging target in hepatocellular carcinoma. J Hepatocell Carcinoma (2015) 0.75
Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells. Toxicol Sci (2016) 0.75
A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo. Drug Metab Dispos (2015) 0.75
Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide. Mol Ther Nucleic Acids (2016) 0.75
Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing. Toxicol Rep (2017) 0.75
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The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol (1991) 3.73
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Fractures in Flexner's foundation: recommended changes in medical education. FASEB J (1992) 2.01
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Cytochrome P450 and the arachidonate cascade. FASEB J (1992) 1.85
Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. Proc Natl Acad Sci U S A (1981) 1.69
Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions. Arch Biochem Biophys (1971) 1.63
Identification and characterization of cDNA clones encoding two homologous proteins that are part of the asialoglycoprotein receptor. Mol Cell Biol (1987) 1.62
Drug interaction with hepatic microsomal cytochrome. Mol Pharmacol (1966) 1.55
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase. Arch Biochem Biophys (1983) 1.55
Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital. Biochem Biophys Res Commun (1969) 1.47
Studies of baker's yeast metabolism. II. The role of adenine nucleotides and inorganic phosphate in the control of respiration during alcohol oxidation. Arch Biochem Biophys (1967) 1.44
Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids. Proc Natl Acad Sci U S A (1982) 1.31
The high-level expression in Escherichia coli of the membrane-bound form of human and rat cytochrome b5 and studies on their mechanism of function. Arch Biochem Biophys (1994) 1.29
Formation of functional asialoglycoprotein receptor after transfection with cDNAs encoding the receptor proteins. Proc Natl Acad Sci U S A (1986) 1.24
A quantitative test for superoxide radicals produced in biological systems. Biochem J (1982) 1.22
Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs). Arch Biochem Biophys (1985) 1.21
Temperature dependence of cytochrome P-450 reduction. A model for NADPH-cytochrome P-450 reductase:cytochrome P-450 interaction. J Biol Chem (1976) 1.20
Factors influencing the inhibitory effect of carbon monoxide on cytochrome P-450-catalyzed mixed function oxidation reactions. Ann N Y Acad Sci (1970) 1.17
Biochemical and genetic factors influencing drug metabolism. Influence of hepatic microsomal mixed function oxidation reactions on cellular metabolic control. Metabolism (1971) 1.17
Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc Natl Acad Sci U S A (1988) 1.16
High-level expression of functional human cytochrome P450 1A2 in Escherichia coli. FASEB J (1992) 1.15
A new spectral intermediate associated with cytochrome P-450 function in liver microsomes. Biochem Biophys Res Commun (1971) 1.14
Sex differences in drug metabolism by rat liver microsomes. Mol Pharmacol (1967) 1.12
Fatty acid monooxygenation by cytochrome P-450BM-3. J Biol Chem (1990) 1.12
Electron Transport in the Oxysome. Science (1963) 1.11
Kinetic studies of temperature changes and oxygen uptake in a differential calorimeter: the heat of oxidation of NADH and succinate. Arch Biochem Biophys (1967) 1.09
Cytochrome P-450 of liver microsomes--one pigment or many. Biochem Biophys Res Commun (1968) 1.09
Inhibition of rat liver microsomal cytochrome P-450 steroid hydroxylase reactions by imidazole antimycotic agents. Biochem Pharmacol (1986) 1.08
Spectroscopic studies on spinach ferredoxin and adrenodoxin. Biochemistry (1967) 1.07
The oxidative metabolism of arachidonic acid by purified cytochromes P-450. Biochem Biophys Res Commun (1981) 1.06
Microsomal electron transport reactions. 3. Cooperative interactions between reduced diphosphopyridine nucleotide and reduced triphosphopyridine nucleotide linked reactions. Arch Biochem Biophys (1971) 1.04
Mitochondrial malic enzyme: the source of reduced nicotinamide adenine dinucleotide phosphate for steroid hydroxylation in bovine adrenal cortex mitochondria. Arch Biochem Biophys (1969) 1.04
Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450. Arch Biochem Biophys (1980) 1.04
Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LA omega) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator. Cancer Res (1989) 1.03
Maple syrup urine disease in Mennonites. Evidence that the Y393N mutation in E1 alpha impedes assembly of the E1 component of branched-chain alpha-keto acid dehydrogenase complex. J Clin Invest (1991) 1.02
Observations on the inhibitor sensitivity of the choline oxidation system. Arch Biochem Biophys (1966) 1.01
Drugs, alcohol and sex hormones: a molecular perspective of the receptivity of cytochrome P-450. Ann N Y Acad Sci (1973) 1.00
Studies of the DPNH-cytochrome b segment of the respiratory chain of baker's yeast. Biochem Biophys Res Commun (1966) 1.00
Purification and enzymatic properties of a recombinant fusion protein expressed in Escherichia coli containing the domains of bovine P450 17A and rat NADPH-P450 reductase. Arch Biochem Biophys (1994) 0.98
Cloning and expression in Escherichia coli of mature E1 beta subunit of bovine mitochondrial branched-chain alpha-keto acid dehydrogenase complex. Mapping of the E1 beta-binding region on E2. J Biol Chem (1992) 0.97
Purification, characterization, and cDNA cloning of an NADPH-cytochrome P450 reductase from mung bean. Proc Natl Acad Sci U S A (1993) 0.97
Lifetime of adrenal cytochrome P-450 as influenced by ACTH. Ann N Y Acad Sci (1973) 0.97
Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase. Proc Natl Acad Sci U S A (1993) 0.97
The nucleotide sequence of rabbit liver cytochrome b5 mRNA. Protein Seq Data Anal (1988) 0.97
On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain. Arch Biochem Biophys (1971) 0.96
Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions. Biochemistry (2001) 0.96
Transformation of an arachidonic acid hydroperoxide into epoxyhydroxy and trihydroxy fatty acids by liver microsomal cytochrome P-450. Arch Biochem Biophys (1987) 0.95
In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices. Drug Metab Dispos (1995) 0.94
Mitochondrial Structure and Function--A "Compostium". Science (1964) 0.94
Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function. Methods Enzymol (1991) 0.94
Application of electrochemistry for P450-catalyzed reactions. Methods Enzymol (1996) 0.94
The preparation of microsomal fractions of rodent respiratory tract and their characterization. Cancer Res (1974) 0.94
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. J Clin Endocrinol Metab (1993) 0.93
High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein. Proc Natl Acad Sci U S A (1992) 0.93
The influence of deuterium oxide and organic solvents on the interaction of respiratory chain components. J Biol Chem (1966) 0.92
Occurrence of a Tyr393----Asn (Y393N) mutation in the E1 alpha gene of the branched-chain alpha-keto acid dehydrogenase complex in maple syrup urine disease patients from a Mennonite population. Am J Hum Genet (1991) 0.91
Microsomal electron-transport reactions: an overview. Methods Enzymol (1978) 0.91
Oxygen interaction with reduced cytochrome P-450. Hoppe Seylers Z Physiol Chem (1968) 0.91
Exercise intolerance, lactic acidosis, and abnormal cardiopulmonary regulation in exercise associated with adult skeletal muscle cytochrome c oxidase deficiency. J Clin Invest (1989) 0.91
Fatty acid monooxygenation by P450BM-3: product identification and proposed mechanisms for the sequential hydroxylation reactions. Arch Biochem Biophys (1992) 0.91
On the use of nicotinamide in assays for microsomal mixed-function oxidase activity. Biochem Pharmacol (1967) 0.91
Microsomal electron transport reactions. II. The use of reduced triphosphopyridine nucleotide and-or reduced diphosphopyridine nucleotide for the oxidative N-demethylation of aminopyrine and other drug substrates. Arch Biochem Biophys (1971) 0.90
The reaction of phenylhydrazine with microsomal cytochrome P-450. Catalysis of heme modification. J Biol Chem (1982) 0.88
Involvement of HxuC outer membrane protein in utilization of hemoglobin by Haemophilus influenzae. Infect Immun (2001) 0.88
Reconstitution of the fatty acid hydroxylation function of cytochrome P-450BM-3 utilizing its individual recombinant hemo- and flavoprotein domains. J Biol Chem (1992) 0.87
Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1. Proc Natl Acad Sci U S A (1995) 0.87
Possible higher valence states of cytochrome P-450 during oxidative reactions. Biochem Biophys Res Commun (1974) 0.87
EPR measurements of substrate interaction with cytochrome P-450. Biochem Biophys Res Commun (1966) 0.87
The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. Arch Biochem Biophys (1996) 0.87
Spin state transitions of liver microsomal cytochrome P-450. Acta Biol Med Ger (1979) 0.87
Structure of the gene encoding the entire mature E1 alpha subunit of human branched-chain alpha-keto acid dehydrogenase complex. FEBS Lett (1991) 0.86
The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain. Arch Biochem Biophys (1996) 0.86
Effect of substrate on the spin state of cytochrome P-450 in hepatic microsomes. Arch Biochem Biophys (1973) 0.85
Spectrophotometric studies of interactions between various substrates in their binding to microsomal cytochrome P-450. Biochem Biophys Res Commun (1969) 0.85
Regulation of cholesterol side-chain cleavage and 17 alpha-hydroxylase/lyase activities in proliferating human theca interna cells in long term monolayer culture. Endocrinology (1989) 0.85
Aldosterone synthesis by adrenal mitochondria. 3. Participation of cytochrome P-450. Arch Biochem Biophys (1967) 0.85
The role of oxygenated cytochrome P-450 and of cytochrome b5 in hepatic microsomal drug oxidations. Drug Metab Dispos (1974) 0.85
CCl4-induced toxicity in isolated hepatocytes: the importance of direct solvent injury. Hepatology (1986) 0.85
The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein. Arch Biochem Biophys (1995) 0.83
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1968) 0.83
Heterogeneity of liver microsomal cytochrome P-450: the spectral characterization of reactants with reduced cytochrome P-450. Arch Biochem Biophys (1975) 0.83
Nonheme iron protein as a possible site of rotenone inhibition of mitochondrial NADH dehydrogenase. Arch Biochem Biophys (1969) 0.83
Maple syrup urine disease: domain structure, mutations and exon skipping in the dihydrolipoyl transacylase (E2) component of the branched-chain alpha-keto acid dehydrogenase complex. Mol Biol Med (1991) 0.83
Snuff-induced hypertension in pheochromocytoma. JAMA (1984) 0.82
Expression of functional bovine cholesterol side chain cleavage cytochrome P450 (P450scc) in Escherichia coli. Arch Biochem Biophys (1991) 0.82
Oxycytochrome P-450: its breakdown to superoxide for the formation of hydrogen peroxide. Acta Biol Med Ger (1979) 0.82