Published in J Biol Chem on May 06, 2014
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature (1994) 4.78
AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem (2004) 3.84
Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature (1992) 3.39
I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol (1997) 2.47
Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci (1998) 2.32
Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27
Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature (1990) 2.06
Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA (2003) 1.97
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood (2007) 1.92
Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem (1996) 1.89
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci U S A (2001) 1.79
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci (2008) 1.71
Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci (2000) 1.45
Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev (2012) 1.38
Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane. Protein Sci (2005) 1.23
Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature (1997) 1.21
Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc Natl Acad Sci U S A (1994) 1.19
Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice. Blood (1997) 1.18
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A (1997) 1.15
Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration. Invest Ophthalmol Vis Sci (1999) 1.14
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle. Cell (1994) 1.14
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor. J Virol (2009) 1.14
Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease. Neurobiol Dis (2001) 1.07
Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes. FEBS Lett (1992) 1.05
Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures. J Neurosci (1991) 1.05
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem (2003) 1.04
Ciliary neurotrophic factor is a regulator of muscular strength in aging. J Neurosci (1999) 1.04
The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes. Proteins (1997) 1.04
IL-6 receptor independent stimulation of human gp130 by viral IL-6. J Immunol (2000) 1.03
Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice. Endocrinology (2006) 1.03
Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system. J Neurosci (1996) 1.02
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. J Biol Chem (2012) 1.01
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6. J Biol Chem (1999) 0.97
Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proc Natl Acad Sci U S A (1993) 0.95
Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease. Proc Natl Acad Sci U S A (1996) 0.94
Circumventing leptin resistance for weight control. Proc Natl Acad Sci U S A (2001) 0.93
Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha expression in astrocytes and neurons of the fascia dentata after entorhinal cortex lesion. J Neurosci (1997) 0.90
Ciliary neurotrophic factor receptor alpha-immunoreactivity in the monkey central nervous system. J Comp Neurol (1997) 0.87
Characterization of the responses of Purkinje cells to neurotrophin treatment. J Neurochem (1996) 0.82
The cytokines cardiotrophin-like cytokine/cytokine-like factor-1 (CLC/CLF) and ciliary neurotrophic factor (CNTF) differ in their receptor specificities. Cytokine (2012) 0.81
The anorectic effect of CNTF does not require action in leptin-responsive neurons. Endocrinology (2012) 0.81
Human CNTF and related cytokines: effects on DRG neurone survival. Neuroreport (1995) 0.79
Human ciliary neurotrophic factor: a structure-function analysis. Biochem J (1995) 0.78
Axokine (Regeneron). IDrugs (2003) 0.77