Published in Inflammopharmacology on May 27, 2014
Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain. Inflammopharmacology (2013) 1.61
Endocannabinoids control spasticity in a multiple sclerosis model. FASEB J (2000) 1.44
The use of sorbitol- and xylitol-sweetened chewing gum in caries control. J Am Dent Assoc (2006) 1.20
Prophylactic efficacy of N-2-hydroxyethyl palmitamide (impulsin) in acute respiratory tract infections. Eur J Clin Pharmacol (1974) 0.95
The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. Cell Death Dis (2013) 0.92
UK academic drug discovery. Nat Rev Drug Discov (2014) 0.90
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice. Br J Nutr (2012) 0.88
An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin Ther (2013) 0.87
Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold. Int J Inflam (2013) 0.83
A case series of a luteolin formulation (NeuroProtek®) in children with autism spectrum disorders. Int J Immunopathol Pharmacol (2012) 0.83
Excipient selection can significantly affect solid-state phase transformation in formulation during wet granulation. AAPS PharmSciTech (2005) 0.79
Excipients with specialized functions for effective drug delivery. Expert Opin Drug Deliv (2011) 0.78
The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. J Thromb Haemost (2008) 0.78
Non-specific resistance induced by palmitoylethanolamide. Toxicon (1972) 0.77
Mechanism of platelet activation induced by endocannabinoids in blood and plasma. Platelets (2013) 0.75
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature (2009) 2.13
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors. Br J Pharmacol (2005) 1.84
CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Neuron (2009) 1.79
The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB J (2009) 1.71
Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain. Inflammopharmacology (2013) 1.61
DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med (2008) 1.49
Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Glia (2008) 1.44
Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. Br J Pharmacol (2002) 1.40
The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness. Exp Cell Res (2003) 1.34
Alpha-synuclein and Parkinson's disease. FASEB J (2004) 1.27
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation. Bioorg Med Chem (2005) 1.26
Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression. Cancer Res (2004) 1.26
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J Biol Chem (2006) 1.20
Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J (2012) 1.18
Opioids in Italy: is marketing more powerful than the law? Lancet (2003) 1.13
Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Psychiatr Genet (2009) 1.13
MET overexpression turns human primary osteoblasts into osteosarcomas. Cancer Res (2006) 1.09
Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis. Cancer Res (2010) 1.05
Abeta(1-42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: a quantitative analysis. J Neurosci Methods (2008) 1.04
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. J Med Chem (2012) 1.03
P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro. Glia (2006) 1.02
The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. Br J Pharmacol (2010) 1.01
Mast cells, glia and neuroinflammation: partners in crime? Immunology (2014) 0.99
Evaluation of the prescription and utilization patterns of statins in an Italian local health unit during the period 1994-2003. Eur J Clin Pharmacol (2007) 0.97
Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator. Mol Neurobiol (2013) 0.95
Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization. J Med Chem (2009) 0.95
Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. Biochem Pharmacol (2004) 0.95
MAP kinase pathways in neuronal cell death. CNS Neurol Disord Drug Targets (2008) 0.93
Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. J Med Chem (2008) 0.93
Opioid prescription for terminally ill outpatients in a district of northern Italy: a retrospective survey. Pharmacol Res (2003) 0.92
Reduction of GAG storage in MPS II mouse model following implantation of encapsulated recombinant myoblasts. J Gene Med (2005) 0.92
On the death Trk. Dev Neurobiol (2010) 0.92
Neuroinflammation, microglia and mast cells in the pathophysiology of neurocognitive disorders: a review. CNS Neurol Disord Drug Targets (2014) 0.91
Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide. Philos Trans R Soc Lond B Biol Sci (2012) 0.91
Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy. Bioorg Med Chem (2005) 0.91
N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor. J Med Chem (2004) 0.90
Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke? J Cereb Blood Flow Metab (2005) 0.89
Generation of a alpha-synuclein-based rat model of Parkinson's disease. Neurobiol Dis (2007) 0.89
Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism. J Neuroimmunol (2011) 0.88
Endocannabinoids: a unique opportunity to develop multitarget analgesics. Pain (2013) 0.88
Runx transcription factors: lineage-specific regulators of neuronal precursor cell proliferation and post-mitotic neuron subtype development. J Cell Biochem (2009) 0.88
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species. Bioorg Med Chem (2007) 0.88
CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice. J Clin Invest (2012) 0.88
alpha-Synuclein- and MPTP-generated rodent models of Parkinson's disease and the study of extracellular striatal dopamine dynamics: a microdialysis approach. CNS Neurol Disord Drug Targets (2010) 0.88
Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets. Innate Immun (2010) 0.87
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. J Med Chem (2012) 0.87
TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells. Biochim Biophys Acta (2007) 0.87
Ventricular cerebrospinal fluid melatonin concentrations investigated with an endoscopic technique. J Pineal Res (2007) 0.86
Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum. Biochem Pharmacol (2008) 0.86
N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution. Mol Neurobiol (2015) 0.86
WIS-NeuroMath enables versatile high throughput analyses of neuronal processes. Dev Neurobiol (2012) 0.85
Up-regulation of A(2A) adenosine receptors by proinflammatory cytokines in rat PC12 cells. Biochem Pharmacol (2002) 0.84
A proteomic approach in the study of an animal model of Parkinson's disease. Clin Chim Acta (2005) 0.84
Mesenchymal stem cells enhance GABAergic transmission in co-cultured hippocampal neurons. Mol Cell Neurosci (2012) 0.84
Inhibition of lipid a stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides. Angew Chem Int Ed Engl (2007) 0.83
Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. Vet J (2011) 0.83
PK 11195 differentially affects cell survival in human wild-type and 18 kDa translocator protein-silenced ADF astrocytoma cells. J Cell Biochem (2008) 0.83
Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved. Phytother Res (2008) 0.83
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem (2011) 0.82
Rimonabant, a cannabinoid CB1 receptor antagonist, attenuates mechanical allodynia and counteracts oxidative stress and nerve growth factor deficit in diabetic mice. Eur J Pharmacol (2010) 0.82
A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment. Int J Neuropsychopharmacol (2011) 0.82
MicroRNAs: emerging role in the endogenous μ opioid system. CNS Neurol Disord Drug Targets (2015) 0.82
A dimeric version of the short N-cadherin binding motif HAVDI promotes neuronal cell survival by activating an N-cadherin/fibroblast growth factor receptor signalling cascade. Mol Cell Neurosci (2004) 0.81
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J Med Chem (2005) 0.81
A(2A) adenosine receptor ligands and proinflammatory cytokines induce PC 12 cell death through apoptosis. Biochem Pharmacol (2003) 0.81
Astrocyte-microglia cooperation in the expression of a pro-inflammatory phenotype. CNS Neurol Disord Drug Targets (2013) 0.81
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists. J Med Chem (2005) 0.80
Thiol-ene mediated neoglycosylation of collagen patches: a preliminary study. Langmuir (2014) 0.80
Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage. Neurobiol Aging (2006) 0.80
Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors. Brain Res (2008) 0.80
Oligodendrocytes are a novel source of amyloid peptide generation. Neurochem Res (2009) 0.80
Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide. CNS Neurol Disord Drug Targets (2013) 0.80
Mast cells in chronic inflammation, pelvic pain and depression in women. Gynecol Endocrinol (2014) 0.79
Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress. Phytother Res (2009) 0.79
PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a new mitochondrial benzodiazepine-receptor ligand, induces apoptosis in C6 glioma cells. Chembiochem (2005) 0.79
Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res (2012) 0.79
Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives. Pharmacol Biochem Behav (2010) 0.79
Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics. Pharmacol Res (2013) 0.79
Responsiveness of hepatic and cerebral cytochrome P450 in rat offspring prenatally and lactationally exposed to a reconstituted PCB mixture. Environ Toxicol (2012) 0.79
Effects of the neurotoxin MPTP and pargyline protection on extracellular energy metabolites and dopamine levels in the striatum of freely moving rats. Brain Res (2013) 0.79
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. Eur J Med Chem (2011) 0.78
MEK inhibition exacerbates ischemic calcium imbalance and neuronal cell death in rat cortical cultures. Eur J Pharmacol (2006) 0.78
Chronic pain and neurodegenerative processes in elderly people. Pain Pract (2014) 0.78
Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt. Org Biomol Chem (2014) 0.78
Consumption of opioid analgesics in italy: light at the end of the tunnel? Eur J Pain (2011) 0.78
P2X(7) Receptors in Neurological and Cardiovascular Disorders. Cardiovasc Psychiatry Neurol (2009) 0.78
Transgenic mouse models of Parkinson's disease and Huntington's disease. CNS Neurol Disord Drug Targets (2010) 0.78
Damaging effects of gliadin on three-dimensional cell culture model. World J Gastroenterol (2005) 0.78