The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3943850)

Published in Tissue Barriers on December 10, 2013

Authors

Tim Vanuytsel1, Séverine Vermeire1, Isabelle Cleynen1

Author Affiliations

1: Department of Clinical and Experimental Medicine; TARGID; KU Leuven.

Articles citing this

Methods to determine intestinal permeability and bacterial translocation during liver disease. J Immunol Methods (2015) 0.90

The role of the microbiota in ageing: current state and perspectives. Wiley Interdiscip Rev Syst Biol Med (2015) 0.85

Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue Barriers (2016) 0.78

Role of Haptoglobin in Health and Disease: A Focus on Diabetes. Clin Diabetes (2016) 0.75

Higher Levels of Serum Zonulin May Rather Be Associated with Increased Risk of Obesity and Hyperlipidemia, Than with Gastrointestinal Symptoms or Disease Manifestations. Int J Mol Sci (2017) 0.75

Tissue Barriers: Introducing an exciting new journal. Temperature (Austin) (2014) 0.75

Calprotectin in serum and zonulin in serum and feces are elevated after introduction of a diet with lower carbohydrate content and higher fiber, fat and protein contents. Biomed Rep (2017) 0.75

Celiac Disease: Role of the Epithelial Barrier. Cell Mol Gastroenterol Hepatol (2017) 0.75

Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model. Ann N Y Acad Sci (2017) 0.75

Rosuvastatin Decreases Intestinal Fatty Acid Binding Protein (I-FABP), but Does Not Alter Zonulin or Lipopolysaccharide Binding Protein (LBP) Levels, in HIV-Infected Subjects on Antiretroviral Therapy. Pathog Immun (2016) 0.75

Identification of a protein associated with the activity of cytokine-induced killer cells. Oncol Lett (2017) 0.75

Fecal zonulin is elevated in Crohn's disease and in cigarette smokers. Pract Lab Med (2017) 0.75

Zonulin: A Potential Marker of Intestine Injury in Newborns. Dis Markers (2017) 0.75

Articles cited by this

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57

Unravelling the pathogenesis of inflammatory bowel disease. Nature (2007) 18.52

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology (2011) 12.09

The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol (2003) 8.28

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98

Intestinal mucosal barrier function in health and disease. Nat Rev Immunol (2009) 7.15

The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem (1998) 5.34

Proteinase-activated receptors. Pharmacol Rev (2001) 5.02

Claudins and epithelial paracellular transport. Annu Rev Physiol (2006) 4.79

Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology (2001) 4.44

Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem (1996) 4.02

Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study. Gastroenterology (2013) 3.55

Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proc Natl Acad Sci U S A (1991) 3.43

Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet (1993) 3.42

Barrier function of epithelia. Am J Physiol (1981) 3.21

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A (1998) 2.88

Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet (2000) 2.82

Clinical practice. Celiac disease. N Engl J Med (2012) 2.79

Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol (2011) 2.67

A persistent defect in intestinal permeability in coeliac disease demonstrated by a 51Cr-labelled EDTA absorption test. Lancet (1983) 2.62

Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther (2012) 2.46

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol (2008) 2.42

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci (2008) 2.36

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut (2008) 2.30

Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes (2006) 2.29

Cloning of a gene (zot) encoding a new toxin produced by Vibrio cholerae. Infect Immun (1992) 2.18

Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut (2005) 2.17

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest (1995) 2.14

Haptoglobin phenotype is an independent risk factor for cardiovascular disease in individuals with diabetes: The Strong Heart Study. J Am Coll Cardiol (2002) 2.08

Duplication within the haptoglobin Hp2 gene. Nature (1984) 2.08

Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology (2002) 2.02

Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology (2008) 1.98

Haptoglobin: basic and clinical aspects. Antioxid Redox Signal (2010) 1.94

Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR. Clin Chem (2002) 1.90

Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm Bowel Dis (1999) 1.88

Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev (2011) 1.85

Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut (2003) 1.84

Clustering of increased small intestinal permeability in families with Crohn's disease. Gastroenterology (1997) 1.84

Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol (2006) 1.81

Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci (2000) 1.78

Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A (2009) 1.67

Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet (2004) 1.66

Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A (2005) 1.65

Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology (2000) 1.63

Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction. Diabetes (2005) 1.53

The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther (2007) 1.49

Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr Opin Gastroenterol (2006) 1.48

Intestinal permeability in patients with Crohn's disease and their first degree relatives. Gut (1992) 1.42

Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores. J Cell Sci (2005) 1.40

Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release. Immunology (2003) 1.31

Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J Clin Invest (1997) 1.31

Haptoglobin phenotypes in health and disorders. Am J Clin Pathol (2004) 1.31

Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res (1998) 1.27

Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin. Atherosclerosis (2006) 1.26

Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J Biol Chem (2001) 1.25

Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. PLoS One (2012) 1.23

The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology (1997) 1.23

Haptoglobin polymorphisms and iron homeostasis in health and in disease. Clin Chim Acta (2004) 1.18

Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology (2005) 1.11

Proteomic analysis of plasma from patients with systemic lupus erythematosus: increased presence of haptoglobin alpha2 polypeptide chains over the alpha1 isoforms. Proteomics (2006) 1.10

Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Diabetologia (2010) 1.06

A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am J Gastroenterol (2012) 1.05

Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci. Inflamm Bowel Dis (2002) 1.04

The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation. FASEB J (2010) 1.00

Hemolytic anemias. Diagnosis and management. Med Clin North Am (1992) 0.99

Increased plasma zonulin in patients with sepsis. Biochem Med (Zagreb) (2013) 0.98

Gut microbiota, microinflammation, metabolic profile, and zonulin concentration in obese and normal weight subjects. Int J Endocrinol (2013) 0.98

Expression of Vibrio cholerae zonula occludens toxin and analysis of its subcellular localization. Microb Pathog (1999) 0.95

Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides (2012) 0.95

Protease-activated receptor 2 and gut permeability: a review. Neurogastroenterol Motil (2008) 0.94

Haptoglobin and the Th1/Th2 balance: hints from in vitro and in vivo studies. Redox Rep (2001) 0.90

Isolation and characterization of bovine haptoglobin from acute phase sera. J Biol Chem (1991) 0.90

Increased small intestinal permeability in ulcerative colitis: rather genetic than environmental and a risk factor for extensive disease? Inflamm Bowel Dis (2012) 0.89

Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system. Am J Physiol Lung Cell Mol Physiol (2013) 0.89

Haptoglobin deficiency facilitates the development of autoimmune inflammation. Eur J Immunol (2009) 0.88

TaqMan-based real-time PCR for genotyping common polymorphisms of haptoglobin (HP1 and HP2). Clin Chem (2008) 0.87

Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm (2008) 0.85

Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test. World J Gastroenterol (2011) 0.84

Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis. Gut (2011) 0.84

A comparison of serum mucoprotein with serum alpha 1 acid glycoprotein, haptoglobin, and alpha 1 antitrypsin assays in monitoring inflammatory bowel disease. Clin Chim Acta (1990) 0.82

Haptoglobin polymorphisms are associated with Crohn's disease, disease behavior, and extraintestinal manifestations in Hungarian patients. Dig Dis Sci (2007) 0.82

Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus. Diabetes Metab Res Rev (2007) 0.81

Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A. Int J Pharm (2007) 0.80

PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat. Am J Physiol Gastrointest Liver Physiol (2012) 0.80

Haptoglobin genotype and endothelial function in diabetes mellitus: a pilot study. Eur J Appl Physiol (2009) 0.79

Structure-activity relationship studies of permeability modulating peptide AT-1002. Bioorg Med Chem Lett (2008) 0.79

The impact of AT1002 on the delivery of ritonavir in the presence of bioadhesive polymer, carrageenan. Arch Pharm Res (2012) 0.79

Characterization of the mouse haptoglobin gene. Genomics (1993) 0.77

The association of Haptoglobin polymorphism with Crohn's disease in Israel. J Crohns Colitis (2008) 0.76