Published in Lancet on April 29, 2000
Oat Products in the Treatment of Coeliac Disease in Children | NCT00808301
Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol (2009) 2.63
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut (2008) 2.30
Environmental enteropathy: critical implications of a poorly understood condition. Trends Mol Med (2012) 2.29
Alterations in intestinal permeability. Gut (2006) 2.17
Between celiac disease and irritable bowel syndrome: the "no man's land" of gluten sensitivity. Am J Gastroenterol (2009) 2.02
Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology (2008) 1.98
Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut (2003) 1.84
Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A (2009) 1.67
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A (2005) 1.65
Intestinal permeability--a new target for disease prevention and therapy. BMC Gastroenterol (2014) 1.52
Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci (2009) 1.39
Intestinal permeability in coeliac disease. Lancet (2001) 1.39
Novel therapies for coeliac disease. J Intern Med (2011) 1.17
Intestinal permeability in long-term follow-up of patients with celiac disease on a gluten-free diet. Dig Dis Sci (2005) 1.14
The immune recognition of gluten in coeliac disease. Clin Exp Immunol (2005) 1.10
Host responses to intestinal microbial antigens in gluten-sensitive mice. PLoS One (2009) 1.08
Immune reaction against the cytoskeleton in coeliac disease. Gut (2000) 1.07
Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients (2015) 1.06
Review article: coeliac disease, new approaches to therapy. Aliment Pharmacol Ther (2012) 1.04
Silent celiac disease activated by pancreaticoduodenectomy. Dig Dis Sci (2007) 1.00
Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci (2012) 1.00
Increased plasma zonulin in patients with sepsis. Biochem Med (Zagreb) (2013) 0.98
Intestinal zonulin: open sesame! Gut (2001) 0.97
Mechanisms of disease: protease functions in intestinal mucosal pathobiology. Nat Clin Pract Gastroenterol Hepatol (2007) 0.94
Dietary gluten and the development of type 1 diabetes. Diabetologia (2014) 0.94
Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease. Virchows Arch (2010) 0.93
Campylobacter concisus and inflammatory bowel disease. World J Gastroenterol (2014) 0.93
IBD candidate genes and intestinal barrier regulation. Inflamm Bowel Dis (2014) 0.92
Intestinal epithelial cells and their role in innate mucosal immunity. Cell Tissue Res (2010) 0.92
Hepatic manifestations of celiac disease. Clin Exp Gastroenterol (2010) 0.91
The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease. Tissue Barriers (2013) 0.91
Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system. Am J Physiol Lung Cell Mol Physiol (2013) 0.89
Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. Am J Pathol (2008) 0.89
A comparison of antibody testing, permeability testing, and zonulin levels with small-bowel biopsy in celiac disease patients on a gluten-free diet. Dig Dis Sci (2009) 0.87
The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. Therap Adv Gastroenterol (2016) 0.86
Novel therapeutic/integrative approaches for celiac disease and dermatitis herpetiformis. Clin Dev Immunol (2012) 0.85
Antibodies to the wheat storage globulin Glo-3A in children before and at diagnosis of celiac disease. J Pediatr Gastroenterol Nutr (2011) 0.85
Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol (2013) 0.83
Does celiac disease trigger autoimmune thyroiditis? Nat Rev Endocrinol (2009) 0.83
Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease. World J Gastroenterol (2014) 0.82
Biomarkers of postoperative delirium and cognitive dysfunction. Front Aging Neurosci (2015) 0.82
Anti-microbial antibodies in celiac disease: trick or treat? World J Gastroenterol (2009) 0.82
Intestinal permeability and antigliadin antibody test for monitoring adult patients with celiac disease. Dig Dis Sci (2007) 0.82
Protective Effects of Bifidobacterium on Intestinal Barrier Function in LPS-Induced Enterocyte Barrier Injury of Caco-2 Monolayers and in a Rat NEC Model. PLoS One (2016) 0.81
Etiopathogenesis of type 1 diabetes mellitus: prognostic factors for the evolution of residual beta cell function. Diabetol Metab Syndr (2009) 0.81
Therapeutic approaches for celiac disease. Best Pract Res Clin Gastroenterol (2015) 0.81
A metabolomic perspective on coeliac disease. Autoimmune Dis (2014) 0.80
Emerging therapeutic options for celiac disease: potential alternatives to a gluten-free diet. Gastroenterol Hepatol (N Y) (2012) 0.80
The Role of Gluten in Celiac Disease and Type 1 Diabetes. Nutrients (2015) 0.79
What role does wheat play in the symptoms of irritable bowel syndrome? Gastroenterol Hepatol (N Y) (2013) 0.79
New and developing therapies for celiac disease. Therap Adv Gastroenterol (2009) 0.79
Celiac disease: a disorder emerging from antiquity, its evolving classification and risk, and potential new treatment paradigms. Gut Liver (2015) 0.79
Celiac disease in patients with type 1 diabetes: a condition with distinct changes in intestinal immunity? Cell Mol Immunol (2011) 0.79
The immunopathogenesis of celiac disease reveals possible therapies beyond the gluten-free diet. Semin Immunopathol (2012) 0.78
Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue Barriers (2016) 0.78
Coherent somatic mutation in autoimmune disease. PLoS One (2014) 0.78
Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study. PLoS One (2015) 0.78
Intestinal stem cells and celiac disease. World J Stem Cells (2014) 0.78
The intestinal epithelial barrier: a therapeutic target? Nat Rev Gastroenterol Hepatol (2016) 0.78
Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial. BMC Gastroenterol (2015) 0.78
Current and emerging therapy for celiac disease. Front Med (Lausanne) (2014) 0.78
Retracted Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin. J Drug Target (2006) 0.77
Circulating Zonulin Correlates with Density of Enteroviruses and Tolerogenic Dendritic Cells in the Small Bowel Mucosa of Celiac Disease Patients. Dig Dis Sci (2016) 0.77
Abnormal apical-to-basal transport of dietary ovalbumin by secretory IgA stimulates a mucosal Th1 response. Mucosal Immunol (2013) 0.76
Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1. PLoS One (2015) 0.76
Beta-cell autoimmunity in pediatric celiac disease: the case for routine screening? Diabetes Care (2008) 0.76
Role of the gastrointestinal ecosystem in the development of type 1 diabetes. Pediatr Diabetes (2015) 0.76
Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial. EBioMedicine (2016) 0.76
Celiac disease: Alternatives to a gluten free diet. World J Gastrointest Pharmacol Ther (2010) 0.75
Human Intestinal Barrier Function in Health and Disease. Clin Transl Gastroenterol (2016) 0.75
Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model. Ann N Y Acad Sci (2017) 0.75
Regulation of intestinal permeability: The role of proteases. World J Gastroenterol (2017) 0.75
Immunopathogenesis and therapeutic approaches in pediatric celiac disease. Expert Rev Clin Immunol (2016) 0.75
The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome. Pediatrics (2016) 0.75
Coeliac disease: a unique model for investigating broken tolerance in autoimmunity. Clin Transl Immunology (2016) 0.75
Severe refractory coeliac disease with response only to parenteral nutrition. Case Rep Gastroenterol (2014) 0.75
Celiac crisis with ataxia in a child. Clinics (Sao Paulo) (2011) 0.75
Relationship between plasma levels of zonulin, bacterial lipopolysaccharides, D-lactate and markers of inflammation in haemodialysis patients. Int Urol Nephrol (2017) 0.75
Gliadin-Specific T-Cells Mobilized in the Peripheral Blood of Coeliac Patients by Short Oral Gluten Challenge: Clinical Applications. Nutrients (2015) 0.75
A role for intestinal TLR4-driven inflammatory response during activity-based anorexia. Sci Rep (2016) 0.75
Bio-physical characteristics of gastrointestinal mucosa of celiac patients: comparison with control subjects and effect of gluten free diet-. BMC Gastroenterol (2011) 0.75
Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women. Sci Rep (2017) 0.75
Zonulin: A Potential Marker of Intestine Injury in Newborns. Dis Markers (2017) 0.75
Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD. Sci Rep (2017) 0.75
Treatment with Entinostat heals experimental cholera by affecting physical and chemical barrier functions of intestinal epithelia. Antimicrob Agents Chemother (2017) 0.75
Fecal zonulin is elevated in Crohn's disease and in cigarette smokers. Pract Lab Med (2017) 0.75
Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models. Acc Chem Res (2000) 10.78
A new class of membrane-bound chemokine with a CX3C motif. Nature (1997) 7.87
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell (1998) 7.58
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science (1999) 7.51
Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science (1994) 5.47
Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature (2011) 5.41
Rapid evolution of male reproductive genes in the descent of man. Nature (2000) 5.33
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development (1995) 5.18
"Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc Natl Acad Sci U S A (1998) 5.02
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell (1998) 4.95
Bone development. Annu Rev Cell Dev Biol (2000) 4.24
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. Proc Natl Acad Sci U S A (2000) 3.16
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell (2000) 2.94
The humoral response in the pathogenesis of gluten ataxia. Neurology (2002) 2.84
Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette. Proc Natl Acad Sci U S A (1993) 2.81
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature (2005) 2.74
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
Paternal population history of East Asia: sources, patterns, and microevolutionary processes. Am J Hum Genet (2001) 2.71
A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol Cell Biol (2000) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
The intermediate endpoint effect in logistic and probit regression. Clin Trials (2007) 2.67
Variable assortment of prophages provides a transferable repertoire of pathogenic determinants in Salmonella. Mol Microbiol (2001) 2.63
Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol (1994) 2.59
Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood (1999) 2.59
Atrial G protein-activated K+ channel: expression cloning and molecular properties. Proc Natl Acad Sci U S A (1993) 2.57
Sino-MONICA project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part i: morbidity and mortality monitoring. Circulation (2001) 2.56
Use of MM-PBSA in reproducing the binding free energies to HIV-1 RT of TIBO derivatives and predicting the binding mode to HIV-1 RT of efavirenz by docking and MM-PBSA. J Am Chem Soc (2001) 2.55
Mass screening for coeliac disease using antihuman transglutaminase antibody assay. Arch Dis Child (2004) 2.54
Hormonal changes in the grains of rice subjected to water stress during grain filling. Plant Physiol (2001) 2.52
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev (1999) 2.52
Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther (2001) 2.51
Genetic influence on the structural variations of the abnormal prion protein. Proc Natl Acad Sci U S A (2000) 2.46
Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains. Infect Immun (1995) 2.45
All-cause mortality and cardiovascular disease mortality in three American Indian populations, aged 45-74 years, 1984-1988. The Strong Heart Study. Am J Epidemiol (1998) 2.43
Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine. J Natl Cancer Inst (2001) 2.41
Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J Appl Physiol (1985) (1985) 2.40
Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease. Blood (1990) 2.38
Pattern of marine mass extinction near the Permian-Triassic boundary in South China. Science (2000) 2.38
De novo amyloid proteins from designed combinatorial libraries. Proc Natl Acad Sci U S A (1999) 2.38
Enterotoxigenicity of Vibrio parahaemolyticus with and without genes encoding thermostable direct hemolysin. Infect Immun (1992) 2.35
Enteroaggregative Escherichia coli elaborate a heat-stable enterotoxin demonstrable in an in vitro rabbit intestinal model. J Clin Invest (1991) 2.35
Predicting caries in permanent teeth from caries in primary teeth: an eight-year cohort study. J Dent Res (2002) 2.35
ATPase activity of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (1996) 2.33
A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia. Blood (1993) 2.29
Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J Clin Invest (1998) 2.29
Enteroaggregative Escherichia coli heat-stable enterotoxin 1 represents another subfamily of E. coli heat-stable toxin. Proc Natl Acad Sci U S A (1993) 2.28
A family of chromatin remodeling factors related to Williams syndrome transcription factor. Proc Natl Acad Sci U S A (2000) 2.24
CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med (1997) 2.24
The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proc Natl Acad Sci U S A (1996) 2.24
TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport. Mol Cell (2001) 2.20
Cloning of a gene (zot) encoding a new toxin produced by Vibrio cholerae. Infect Immun (1992) 2.18
Quality of life for children with fecal incontinence after surgically corrected anorectal malformation. J Pediatr Surg (2000) 2.17
Mortality and cardiovascular disease among older live kidney donors. Am J Transplant (2014) 2.16
The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma. Oncogene (2000) 2.15
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest (1995) 2.14
The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science (1998) 2.11
Validity of the ten questions screened for childhood disability: results from population-based studies in Bangladesh, Jamaica, and Pakistan. Epidemiology (1994) 2.10
Hydration of fat-free body mass: new physiological modeling approach. Am J Physiol (1999) 2.09
Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies. Ultrasound Obstet Gynecol (2015) 2.07
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry (2000) 2.03
Repeatability of the Pedar-X in-shoe pressure measuring system. Foot Ankle Surg (2009) 2.03
Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. J Cell Physiol (2001) 2.02
Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation (2000) 2.01
A frame shift mutation in the DNA-binding domain of the androgen receptor gene associated with complete androgen insensitivity, persistent müllerian structures, and germ cell tumors in dysgenetic gonads. Fertil Steril (1999) 2.00
Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Pediatrics (1996) 1.98
The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes (2004) 1.96
Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol (2000) 1.95
HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene (2006) 1.94
The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo. RNA (2001) 1.94
Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover. Mol Cell Biol (2000) 1.93
Safety and immunogenicity of live oral cholera vaccine candidate CVD 110, a delta ctxA delta zot delta ace derivative of El Tor Ogawa Vibrio cholerae. J Infect Dis (1993) 1.93
Molecular characterization of ciprofloxacin-resistant Salmonella enterica serovar Typhi and Paratyphi A causing enteric fever in India. J Antimicrob Chemother (2006) 1.91
Intraocular lens power calculation after laser in situ keratomileusis for myopia and hyperopia: a standardized approach. Cornea (2001) 1.90
H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis. J Cell Biol (1992) 1.89
Curbing the nonsense: the activation and regulation of mRNA surveillance. Genes Dev (2001) 1.87
Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness. J Appl Physiol (1985) (2009) 1.86
Harvesting energy from the marine sediment--water interface. Environ Sci Technol (2001) 1.85
Non-invasive prenatal testing for fetal chromosomal abnormalities by low-coverage whole-genome sequencing of maternal plasma DNA: review of 1982 consecutive cases in a single center. Ultrasound Obstet Gynecol (2014) 1.85
Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut (2003) 1.84
Chemical constituents from Dendrobium densiflorum. Phytochemistry (2001) 1.82
A computational approach to simplifying the protein folding alphabet. Nat Struct Biol (1999) 1.82
Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cells. J Biol Chem (2000) 1.82
The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J (1999) 1.82
Evaluating a ten questions screen for childhood disability: reliability and internal structure in different cultures. J Clin Epidemiol (1995) 1.79
The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity (1997) 1.78
Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure. J Appl Physiol (1985) (1999) 1.78
Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci (2000) 1.78
Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology (2011) 1.77
The prevalence of celiac disease in at-risk groups of children in the United States. J Pediatr (2000) 1.76
Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007. Clin Microbiol Infect (2009) 1.76
Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets. Mol Psychiatry (2011) 1.76
Nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Gene (2001) 1.75
Complete sequence of the RNA genome of human rhinovirus 16, a clinically useful common cold virus belonging to the ICAM-1 receptor group. Virus Genes (1995) 1.74
Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer. Ann Oncol (2011) 1.74