Published in Trials on May 02, 2014
Protective Variable Ventilation for Open Abdominal Surgery (PROVAR) | NCT01683578
Variable ventilation from bench to bedside. Crit Care (2016) 0.96
Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way. World J Crit Care Med (2015) 0.78
Variable lung protective mechanical ventilation decreases incidence of postoperative delirium and cognitive dysfunction during open abdominal surgery. Int J Clin Exp Med (2015) 0.77
Ultra-low-dose sequential computed tomography for quantitative lung aeration assessment-a translational study. Intensive Care Med Exp (2017) 0.75
Variable mechanical ventilation. Rev Bras Ter Intensiva (2017) 0.75
Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia. Respir Res (2016) 0.75
Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial. Oxid Med Cell Longev (2017) 0.75
Protective mechanical ventilation during general anesthesia for open abdominal surgery improves postoperative pulmonary function. Anesthesiology (2013) 5.04
Effects of different levels of pressure support variability in experimental lung injury. Anesthesiology (2009) 2.38
Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation of pressure support. Crit Care Med (2011) 2.34
Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia. Am J Respir Crit Care Med (2004) 1.86
Comparative effects of proportional assist and variable pressure support ventilation on lung function and damage in experimental lung injury. Crit Care Med (2012) 1.83
Life-support system benefits from noise. Nature (1998) 1.81
Noisy pressure support ventilation: a pilot study on a new assisted ventilation mode in experimental lung injury. Crit Care Med (2008) 1.79
Comparison of variable and conventional ventilation in a sheep saline lavage lung injury model. Crit Care Med (2006) 1.67
Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomy. Anesthesiology (2004) 1.65
Biologically variable or naturally noisy mechanical ventilation recruits atelectatic lung. Am J Respir Crit Care Med (2000) 1.60
Physiological noise versus white noise to drive a variable ventilator in a porcine model of lung injury. Can J Anaesth (2008) 1.48
Improved arterial oxygenation after oleic acid lung injury in the pig using a computer-controlled mechanical ventilator. Am J Respir Crit Care Med (1996) 1.44
Lung collapse and gas exchange during general anesthesia: effects of spontaneous breathing, muscle paralysis, and positive end-expiratory pressure. Anesthesiology (1987) 1.37
Breathing patterns. 1. Normal subjects. Chest (1983) 1.33
Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury. Am J Respir Crit Care Med (2009) 1.27
Breathing patterns. 2. Diseased subjects. Chest (1983) 1.27
Variable ventilation induces endogenous surfactant release in normal guinea pigs. Am J Physiol Lung Cell Mol Physiol (2003) 1.25
Late postoperative episodic and constant hypoxaemia and associated ECG abnormalities. Br J Anaesth (1990) 1.22
Relationship between hypoxaemic and cardiac ischaemic events in the perioperative period. Br J Anaesth (1992) 1.20
Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis. Acta Anaesthesiol Scand (1986) 1.10
Design of a new variable-ventilation method optimized for lung recruitment in mice. J Appl Physiol (1985) (2008) 0.97
Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury. J Appl Physiol (1985) (2011) 0.96
Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases. Eur Radiol (2000) 0.94
Effects of recruitment/derecruitment dynamics on the efficacy of variable ventilation. J Appl Physiol (1985) (2011) 0.93
Biologically variable ventilation in patients with acute lung injury: a pilot study. Can J Anaesth (2013) 0.90
The influence of surgical sites on early postoperative hypoxemia in adults undergoing elective surgery. Anesth Analg (1999) 0.88
Airway closure: the silent killer of peripheral airways. Crit Care (2007) 0.83
Comparison of perioperative spirometric data following spinal or general anaesthesia in normal-weight and overweight gynaecological patients. Acta Anaesthesiol Scand (2005) 0.80
Mortality after surgery in Europe: a 7 day cohort study. Lancet (2012) 9.96
Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet (2003) 7.91
Protective mechanical ventilation during general anesthesia for open abdominal surgery improves postoperative pulmonary function. Anesthesiology (2013) 5.04
Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study. Crit Care Med (2005) 4.61
High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. Lancet (2014) 4.45
Intraoperative protective mechanical ventilation for prevention of postoperative pulmonary complications: a comprehensive review of the role of tidal volume, positive end-expiratory pressure, and lung recruitment maneuvers. Anesthesiology (2015) 4.25
Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med (2007) 3.45
Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma (2008) 3.40
Percutaneous dilatational tracheostomy with a double-lumen endotracheal tube: a comparison of feasibility, gas exchange, and airway pressures. Chest (2015) 3.20
Concern Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Eur Heart J (2009) 3.14
The Stability and Workload Index for Transfer score predicts unplanned intensive care unit patient readmission: initial development and validation. Crit Care Med (2008) 3.14
Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med (2006) 3.13
Prospective external validation of a predictive score for postoperative pulmonary complications. Anesthesiology (2014) 3.01
Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med (2013) 2.95
Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med (2006) 2.75
Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med (2004) 2.56
Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med (2010) 2.53
Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care (2010) 2.50
Effects of different levels of pressure support variability in experimental lung injury. Anesthesiology (2009) 2.38
Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation of pressure support. Crit Care Med (2011) 2.34
Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med (2015) 2.25
Clinical and hemostatic responses to treatment in ventilator-associated pneumonia: role of bacterial pathogens. Crit Care Med (2007) 2.20
Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury. Anesthesiology (2006) 2.19
The application of esophageal pressure measurement in patients with respiratory failure. Am J Respir Crit Care Med (2014) 2.16
Characteristics and outcomes of ventilated patients according to time to liberation from mechanical ventilation. Am J Respir Crit Care Med (2011) 2.15
Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med (2009) 2.07
Recommendations for sepsis management in resource-limited settings. Intensive Care Med (2012) 2.03
Outcomes of patients ventilated with synchronized intermittent mandatory ventilation with pressure support: a comparative propensity score study. Chest (2009) 2.03
Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients. Crit Care Med (2013) 2.02
Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover*. Crit Care Med (2012) 2.02
Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy. Intensive Care Med (2010) 2.01
Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients. Intensive Care Med (2004) 1.96
Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. Crit Care (2009) 1.92
A change in the Dutch Directive on Medical Research Involving Human Subjects strongly increases the number of eligible intensive care patients: an observational study. Intensive Care Med (2006) 1.85
Comparative effects of proportional assist and variable pressure support ventilation on lung function and damage in experimental lung injury. Crit Care Med (2012) 1.83
Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation. Am J Respir Crit Care Med (2014) 1.83
The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands. Crit Care (2008) 1.81
Noisy pressure support ventilation: a pilot study on a new assisted ventilation mode in experimental lung injury. Crit Care Med (2008) 1.79
A comparison of RIFLE with and without urine output criteria for acute kidney injury in critically ill patients. Crit Care (2012) 1.78
An Official ATS/ERS/ESICM/SCCM/SRLF Statement: Prevention and Management of Acute Renal Failure in the ICU Patient: an international consensus conference in intensive care medicine. Am J Respir Crit Care Med (2010) 1.77
Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization. Clin Infect Dis (2008) 1.75
Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats. J Appl Physiol (1985) (2007) 1.74
Acute pancreatitis in mice impairs bacterial clearance from the lungs, whereas concurrent pneumonia prolongs the course of pancreatitis. Crit Care Med (2004) 1.73
Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults. Crit Care (2013) 1.72
Supernatant of aged erythrocytes causes lung inflammation and coagulopathy in a "two-hit" in vivo syngeneic transfusion model. Anesthesiology (2010) 1.72
Elimination of daily routine chest radiographs does not change on-demand radiography practice in post-cardiothoracic surgery patients. J Thorac Cardiovasc Surg (2007) 1.69
Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study. Crit Care (2013) 1.66
Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol (2015) 1.64
Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome. Crit Care Med (2012) 1.64
Spontaneous breathing during general anesthesia prevents the ventral redistribution of ventilation as detected by electrical impedance tomography: a randomized trial. Anesthesiology (2012) 1.64
Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice. Crit Care Med (2008) 1.64
Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology (2008) 1.63
Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition. Crit Care Med (2012) 1.63
Circadian rhythms: from basic mechanisms to the intensive care unit. Crit Care Med (2012) 1.63
Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes. Intensive Care Med (2008) 1.63
Effects of partial ventilatory support modalities on respiratory function in severe hypoxemic lung injury. Crit Care Med (2006) 1.60
Predicting Fluid Responsiveness by Passive Leg Raising: A Systematic Review and Meta-Analysis of 23 Clinical Trials. Crit Care Med (2016) 1.60
Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats. Crit Care Med (2008) 1.58
Acute effects of intracranial hypertension and ARDS on pulmonary and neuronal damage: a randomized experimental study in pigs. Intensive Care Med (2011) 1.57
Tandem autologous-allogeneic nonmyeloablative sibling transplantation in relapsed follicular lymphoma leads to impressive progression-free survival with minimal toxicity. Biol Blood Marrow Transplant (2011) 1.55
Pulmonary activation of coagulation and inhibition of fibrinolysis after burn injuries and inhalation trauma. J Trauma (2011) 1.54
Early and small changes in serum creatinine concentrations are associated with mortality in mechanically ventilated patients. Shock (2010) 1.54
In the critically ill patient, diabetes predicts mortality independent of statin therapy but is not associated with acute lung injury: a cohort study. Crit Care Med (2012) 1.53
N(omega)-nitro-L-arginine methyl ester effects on neutrophil function and bacterial clearance. Shock (2004) 1.53
Clinical review: Positive end-expiratory pressure and cardiac output. Crit Care (2005) 1.51
The practice of and documentation on withholding and withdrawing life support: a retrospective study in two Dutch intensive care units. Anesth Analg (2009) 1.51
Impact of pressure profile and duration of recruitment maneuvers on morphofunctional and biochemical variables in experimental lung injury. Crit Care Med (2011) 1.51
Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice. Crit Care Med (2008) 1.49
Modifying the baricity of local anesthetics for spinal anesthesia by temperature adjustment: model calculations. Anesthesiology (2006) 1.48
Effect of different cycling-off criteria and positive end-expiratory pressure during pressure support ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med (2007) 1.48
Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med (2005) 1.48
Development and validation of a score to predict postoperative respiratory failure in a multicentre European cohort: A prospective, observational study. Eur J Anaesthesiol (2015) 1.47
The influence of rewarming after therapeutic hypothermia on outcome after cardiac arrest. Resuscitation (2012) 1.47
Higher levels of spontaneous breathing reduce lung injury in experimental moderate acute respiratory distress syndrome. Crit Care Med (2014) 1.47
Intact nitric oxide production is obligatory for the sustained flow response during hypercapnic acidosis in guinea pig heart. Cardiovasc Res (2004) 1.47
Effectiveness and Clinical Outcomes of a Two-Step Implementation of Conservative Oxygenation Targets in Critically Ill Patients: A Before and After Trial. Crit Care Med (2016) 1.47
High-resolution ultrasound-guided high interscalene plexus block for carotid endarterectomy. Reg Anesth Pain Med (2007) 1.47
Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med (2006) 1.46
Hemodynamics and vasopressor support during targeted temperature management at 33°C Versus 36°C after out-of-hospital cardiac arrest: a post hoc study of the target temperature management trial*. Crit Care Med (2015) 1.46