Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.

PubWeight™: 3.40‹?› | Rank: Top 1%

🔗 View Article (PMID 18469643)

Published in J Trauma on May 01, 2008

Authors

Karim Brohi1, Mitchell J Cohen, Michael T Ganter, Marcus J Schultz, Marcel Levi, Robert C Mackersie, Jean-François Pittet

Author Affiliations

1: Department of Surgery, The Royal London Hospital, London, United Kingdom.

Associated clinical trials:

Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma | NCT01897792

Evaluation of the Safety and Efficacy of the Second Dose of Tranexamic Acid | NCT03846973

Articles citing this

Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65

Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09

Molecular intercommunication between the complement and coagulation systems. J Immunol (2010) 2.12

Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma (2009) 2.04

Blood transfusion and the anaesthetist: management of massive haemorrhage. Anaesthesia (2010) 1.77

Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med (2011) 1.72

Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev (2009) 1.65

Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg (2013) 1.49

Early and individualized goal-directed therapy for trauma-induced coagulopathy. Scand J Trauma Resusc Emerg Med (2012) 1.46

Major burn injury is not associated with acute traumatic coagulopathy. J Trauma Acute Care Surg (2013) 1.43

The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care (2016) 1.43

Acute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients. J Am Coll Surg (2016) 1.42

Clinical review: Canadian National Advisory Committee on Blood and Blood Products--Massive transfusion consensus conference 2011: report of the panel. Crit Care (2011) 1.40

Thrombelastography and tromboelastometry in assessing coagulopathy in trauma. Scand J Trauma Resusc Emerg Med (2009) 1.38

Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg (2012) 1.35

Resuscitative strategies in traumatic hemorrhagic shock. Ann Intensive Care (2013) 1.30

Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Crit Care (2011) 1.26

The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang (2011) 1.15

Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg (2013) 1.13

Hemostatic resuscitation with plasma and platelets in trauma. J Emerg Trauma Shock (2012) 1.08

Acute coagulopathy in trauma: with or without shock? That is the question. Crit Care (2014) 1.05

Massive Bleeding and Massive Transfusion. Transfus Med Hemother (2012) 1.05

Tranexamic acid: less bleeding and less thrombosis? Crit Care (2012) 1.04

Coagulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation. Resuscitation (2009) 1.04

Clotting factor deficiency in early trauma-associated coagulopathy. J Trauma (2011) 1.02

Transfusion practices in trauma. Indian J Anaesth (2014) 1.01

Optimal use of blood in trauma patients. Biologicals (2010) 1.00

Advances in the understanding of trauma-induced coagulopathy. Blood (2016) 0.98

The contemporary role of blood products and components used in trauma resuscitation. Scand J Trauma Resusc Emerg Med (2010) 0.98

Optimal use of blood products in severely injured trauma patients. Hematology Am Soc Hematol Educ Program (2010) 0.95

Critical care considerations in the management of the trauma patient following initial resuscitation. Scand J Trauma Resusc Emerg Med (2012) 0.94

Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients. J Trauma Acute Care Surg (2016) 0.93

Current management of massive hemorrhage in trauma. Scand J Trauma Resusc Emerg Med (2012) 0.91

Acute and delayed mild coagulopathy are related to outcome in patients with isolated traumatic brain injury. Crit Care (2011) 0.90

Plasma is the physiologic buffer of tissue plasminogen activator-mediated fibrinolysis: rationale for plasma-first resuscitation after life-threatening hemorrhage. J Am Coll Surg (2015) 0.90

Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study. Crit Care (2014) 0.89

Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients. J Thromb Haemost (2015) 0.88

Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy. Thromb Res (2014) 0.88

Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers. PLoS One (2013) 0.88

New evidence in trauma resuscitation - is 1:1:1 the answer? Perioper Med (Lond) (2013) 0.88

Comparative response of platelet fV and plasma fV to activated protein C and relevance to a model of acute traumatic coagulopathy. PLoS One (2014) 0.87

Fibrinogen metabolic responses to trauma. Scand J Trauma Resusc Emerg Med (2009) 0.87

Damage control in the injured patient. Int J Crit Illn Inj Sci (2011) 0.87

Trigger mechanisms of secondary sclerosing cholangitis in critically ill patients. Crit Care (2015) 0.86

Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery (2015) 0.85

Deep vein thrombosis prophylaxis in trauma patients. Thrombosis (2011) 0.85

Use of Activated Recombinant Factor VII in Severe Bleeding - Evidence for Efficacy and Safety in Trauma, Postpartum Hemorrhage, Cardiac Surgery, and Gastrointestinal Bleeding. Transfus Med Hemother (2012) 0.84

Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis. Shock (2015) 0.83

Mechanistic determinates of the acute coagulopathy of trauma (ACoT) in patients requiring emergency surgery. Int J Burns Trauma (2012) 0.82

Procoagulant and fibrinolytic activity after polytrauma in rat. Am J Physiol Regul Integr Comp Physiol (2015) 0.82

Hemostasis in liver transplantation: Pathophysiology, monitoring, and treatment. World J Gastroenterol (2016) 0.81

TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy. J Thromb Haemost (2015) 0.81

Evaluation of Prehospital Blood Products to Attenuate Acute Coagulopathy of Trauma in a Model of Severe Injury and Shock in Anesthetized Pigs. Shock (2015) 0.81

The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury. J Trauma Acute Care Surg (2015) 0.81

Role of fibrinogen in cerebrovascular dysfunction after traumatic brain injury. Brain Inj (2013) 0.80

What's new in Emergencies, Trauma and Shock? Coagulation is in the focus! J Emerg Trauma Shock (2010) 0.80

Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock. Shock (2015) 0.80

Interventional Algorithms for the Control of Coagulopathic Bleeding in Surgical, Trauma, and Postpartum Settings: Recommendations From the Share Network Group. Clin Appl Thromb Hemost (2014) 0.80

The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength. J Surg Res (2011) 0.79

Tranexamic acid: from trauma to routine perioperative use. Curr Opin Anaesthesiol (2015) 0.79

What's new in management of traumatic coagulopathy? Intensive Care Med (2014) 0.79

Evaluation of clotting factor activities early after severe multiple trauma and their correlation with coagulation tests and clinical data. World J Emerg Surg (2015) 0.79

Hypotensive Resuscitation. Curr Anesthesiol Rep (2014) 0.79

Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides. ACS Nano (2015) 0.79

International normalized ratio as a predictor of mortality in trauma patients in India. World J Emerg Med (2014) 0.78

Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology (2016) 0.78

Time course of soluble P-selectin and von Willebrand factor levels in trauma patients: a prospective observational study. Scand J Trauma Resusc Emerg Med (2013) 0.78

Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats. Crit Care (2013) 0.78

A non-lethal traumatic/hemorrhagic insult strongly modulates the compartment-specific PAI-1 response in the subsequent polymicrobial sepsis. PLoS One (2013) 0.78

Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid. J Trauma Acute Care Surg (2015) 0.78

Kinetic model facilitates analysis of fibrin generation and its modulation by clotting factors: implications for hemostasis-enhancing therapies. Mol Biosyst (2014) 0.78

Systemic central venous oxygen saturation is associated with clot strength during traumatic hemorrhagic shock: A preclinical observational model. Scand J Trauma Resusc Emerg Med (2010) 0.77

The trauma patient in hemorrhagic shock: how is the C-priority addressed between emergency and ICU admission? Scand J Trauma Resusc Emerg Med (2012) 0.77

In vitro combinations of red blood cell, plasma and platelet components evaluated by thromboelastography. Blood Transfus (2014) 0.77

Scudder Oration on Trauma. A century of evolution in trauma resuscitation. J Am Coll Surg (2014) 0.77

Asphyxia by Drowning Induces Massive Bleeding Due To Hyperfibrinolytic Disseminated Intravascular Coagulation. Crit Care Med (2015) 0.77

Hypercoagulability in response to elevated body temperature and central hypovolemia. J Surg Res (2013) 0.76

Bleeding related to disturbed fibrinolysis. Br J Haematol (2016) 0.76

Wells criteria for DVT is a reliable clinical tool to assess the risk of deep venous thrombosis in trauma patients. World J Emerg Surg (2016) 0.75

Tranexamic Acid (TXA) in Trauma Patients: Barriers to Use among Trauma Surgeons and Emergency Physicians. Emerg Med Int (2017) 0.75

Whole blood thromboelastometry: another Knight at the Roundtable? Crit Care (2011) 0.75

Evaluation of Potential Clinical Surrogate Markers of a Trauma Induced Alteration of Clotting Factor Activities. Biomed Res Int (2016) 0.75

Effect of hypoperfusion and the protein C pathway on the early coagulopathy after traumatic brain injury. J Trauma (2008) 0.75

Maxillofacial and neck trauma: a damage control approach. World J Emerg Surg (2015) 0.75

Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype. J Intensive Care (2017) 0.75

Resuscitation of Polytrauma Patients: The Management of Massive Skeletal Bleeding. Open Orthop J (2015) 0.75

Safety and efficacy of tranexamic acid in bleeding paediatric trauma patients: a systematic review protocol. BMJ Open (2016) 0.75

Coagulation complications following trauma. Mil Med Res (2016) 0.75

Inducing Acute Traumatic Coagulopathy In Vitro: The Effects of Activated Protein C on Healthy Human Whole Blood. PLoS One (2016) 0.75

Updated concepts on the pathophysiology and the clinical management of trauma hemorrhage and coagulopathy. Chin J Traumatol (2017) 0.75

Diverse coagulopathies in a rabbit model with different abdominal injuries. World J Emerg Med (2017) 0.75

The current understanding of trauma-induced coagulopathy (TIC): a focused review on pathophysiology. Intern Emerg Med (2017) 0.75

Engineered isopeptide bond stabilized fibrin inspired nanoscale peptide based sealants for efficient blood clotting. Sci Rep (2017) 0.75

Translational approaches to coagulopathy after trauma: Towards targeted treatment. PLoS Med (2017) 0.75

Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma. Transfusion (2017) 0.75

Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness Such as Trauma or Sepsis? Shock (2017) 0.75

Hyperfibrinolysis and Hypofibrinogenemia Diagnosed With Rotational Thromboelastometry in Dogs Naturally Infected With Angiostrongylus vasorum. J Vet Intern Med (2017) 0.75

Prevalence and Associated Factors of Acute Traumatic Coagulopathy; a Cross Sectional Study. Emerg (Tehran) (2017) 0.75

Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and Consequences. Brain Sci (2017) 0.75

Articles by these authors

Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet (2003) 7.91

Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA (2012) 6.73

Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation (2011) 6.47

Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med (2002) 6.17

Protective mechanical ventilation during general anesthesia for open abdominal surgery improves postoperative pulmonary function. Anesthesiology (2013) 5.04

Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data. Lancet (2011) 4.78

Prevention and treatment of major blood loss. N Engl J Med (2007) 4.72

High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. Lancet (2014) 4.45

Intraoperative protective mechanical ventilation for prevention of postoperative pulmonary complications: a comprehensive review of the role of tidal volume, positive end-expiratory pressure, and lung recruitment maneuvers. Anesthesiology (2015) 4.25

Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med (2004) 3.89

Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg (2007) 3.49

The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg (2013) 3.25

The Stability and Workload Index for Transfer score predicts unplanned intensive care unit patient readmission: initial development and validation. Crit Care Med (2008) 3.14

Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med (2006) 3.13

Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial. Lancet (2003) 2.86

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol (2010) 2.75

Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med (2006) 2.75

The optimal intensity of vitamin K antagonists in patients with mechanical heart valves: a meta-analysis. J Am Coll Cardiol (2003) 2.71

A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68

Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease. Arch Surg (2010) 2.65

Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J Clin Oncol (2002) 2.55

Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med (2010) 2.53

Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care (2007) 2.51

Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care (2010) 2.50

Activation of inflammation and coagulation after infusion of C-reactive protein in humans. Circ Res (2005) 2.46

Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol (2007) 2.46

Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med (2011) 2.39

Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surg (2012) 2.32

Tranexamic acid in trauma: how should we use it? J Trauma Acute Care Surg (2013) 2.32

Clinical and hemostatic responses to treatment in ventilator-associated pneumonia: role of bacterial pathogens. Crit Care Med (2007) 2.20

Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury. Anesthesiology (2006) 2.19

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 2.17

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk. Blood (2010) 2.14

Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med (2005) 2.12

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. Blood (2011) 2.05

Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care (2009) 2.05

Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood (2008) 2.03

Recommendations for sepsis management in resource-limited settings. Intensive Care Med (2012) 2.03

Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients. Crit Care Med (2013) 2.02

Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover*. Crit Care Med (2012) 2.02

Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy. Intensive Care Med (2010) 2.01

Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. Diabetes (2006) 1.97

Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension. Hypertension (2008) 1.95

Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1. Circ Res (2006) 1.95

Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. Crit Care (2009) 1.92

Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. Respir Care (2004) 1.92

Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem (2003) 1.90

Management of adult Jehovah's Witness patients with acute bleeding. Am J Med (2009) 1.89

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood (2007) 1.86

Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem (2005) 1.86

A change in the Dutch Directive on Medical Research Involving Human Subjects strongly increases the number of eligible intensive care patients: an observational study. Intensive Care Med (2006) 1.85

Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation. Am J Respir Crit Care Med (2014) 1.83

Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia. Crit Care Med (2006) 1.82

The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands. Crit Care (2008) 1.81

A comparison of RIFLE with and without urine output criteria for acute kidney injury in critically ill patients. Crit Care (2012) 1.78

The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation. Crit Care Med (2010) 1.78

Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization. Clin Infect Dis (2008) 1.75

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res (2008) 1.73

Acute pancreatitis in mice impairs bacterial clearance from the lungs, whereas concurrent pneumonia prolongs the course of pancreatitis. Crit Care Med (2004) 1.73

Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults. Crit Care (2013) 1.72

Supernatant of aged erythrocytes causes lung inflammation and coagulopathy in a "two-hit" in vivo syngeneic transfusion model. Anesthesiology (2010) 1.72

New fundamentals in hemostasis. Physiol Rev (2013) 1.70

Elimination of daily routine chest radiographs does not change on-demand radiography practice in post-cardiothoracic surgery patients. J Thorac Cardiovasc Surg (2007) 1.69

Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study. Crit Care (2013) 1.66

Struggle for implementation of new strategies in intensive care medicine: anticoagulation, insulin, and lower tidal volumes. J Crit Care (2005) 1.66

Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol (2015) 1.64

Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome. Crit Care Med (2012) 1.64

Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med (2006) 1.64

Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice. Crit Care Med (2008) 1.64

Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology (2008) 1.63

Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes. Intensive Care Med (2008) 1.63

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med (2011) 1.62

Serum levels of mannose-binding lectin and the risk of future coronary artery disease in apparently healthy men and women. Arterioscler Thromb Vasc Biol (2006) 1.62

Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix. J Trauma Acute Care Surg (2012) 1.60

Time course of platelet counts in critically ill patients. Crit Care Med (2002) 1.60

Predicting Fluid Responsiveness by Passive Leg Raising: A Systematic Review and Meta-Analysis of 23 Clinical Trials. Crit Care Med (2016) 1.60

Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats. Crit Care Med (2008) 1.58

Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide. Crit Care Med (2009) 1.55

Pulmonary activation of coagulation and inhibition of fibrinolysis after burn injuries and inhalation trauma. J Trauma (2011) 1.54

In the critically ill patient, diabetes predicts mortality independent of statin therapy but is not associated with acute lung injury: a cohort study. Crit Care Med (2012) 1.53

Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock (2009) 1.53

The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury. J Trauma (2003) 1.52

The practice of and documentation on withholding and withdrawing life support: a retrospective study in two Dutch intensive care units. Anesth Analg (2009) 1.51

Serum levels of Hsp 72 measured early after trauma correlate with survival. J Trauma (2002) 1.49

Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med (2005) 1.48

Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol (2006) 1.47

The influence of rewarming after therapeutic hypothermia on outcome after cardiac arrest. Resuscitation (2012) 1.47

Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome: a comparison between volume and pressure-regulated breathing modes. Respir Care (2005) 1.47

Effectiveness and Clinical Outcomes of a Two-Step Implementation of Conservative Oxygenation Targets in Critically Ill Patients: A Before and After Trial. Crit Care Med (2016) 1.47

Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study. Resuscitation (2011) 1.46

Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med (2008) 1.46