Published in Mol Cancer on June 03, 2014
Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment. Mol Cancer (2016) 1.51
High tumor budding stratifies breast cancer with metastatic properties. Breast Cancer Res Treat (2015) 0.94
Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. Expert Rev Mol Med (2015) 0.87
HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma. J Exp Clin Cancer Res (2015) 0.86
MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1. Oncotarget (2015) 0.84
The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer. Br J Cancer (2015) 0.83
Identifying and targeting tumor-initiating cells in the treatment of breast cancer. Endocr Relat Cancer (2015) 0.81
Combination of cyclopamine and tamoxifen promotes survival and migration of mcf-7 breast cancer cells--interaction of hedgehog-gli and estrogen receptor signaling pathways. PLoS One (2014) 0.81
The hedgehog pathway in triple-negative breast cancer. Cancer Med (2016) 0.80
KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis. Am J Cancer Res (2014) 0.80
The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer. Breast Cancer (Dove Med Press) (2015) 0.80
Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells. Cancer Gene Ther (2016) 0.80
The Role of Hedgehog Signaling in Tumor Induced Bone Disease. Cancers (Basel) (2015) 0.77
Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERα-ΔNp63-Integrin β4 Signaling Pathway. PLoS One (2016) 0.77
Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells. Oncotarget (2016) 0.77
Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide. J Biol Chem (2016) 0.76
Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. Semin Cancer Biol (2016) 0.76
FOXA1 expression affects the proliferation activity of luminal breast cancer stem cell populations. Cancer Sci (2016) 0.76
Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression. Technol Cancer Res Treat (2016) 0.76
Ubiquitin-specific protease 28 is overexpressed in human glioblastomas and contributes to glioma tumorigenicity by regulating MYC expression. Exp Biol Med (Maywood) (2015) 0.76
Ubiquitin-specific protease 4 inhibits breast cancer cell growth through the upregulation of PDCD4. Int J Mol Med (2016) 0.76
Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression. BMC Cancer (2015) 0.75
Essential role of endogenous prolactin and CDK7 in estrogen-induced upregulation of the prolactin receptor in breast cancer cells. Oncotarget (2017) 0.75
Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt. Int J Mol Med (2015) 0.75
Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma. Int J Mol Med (2016) 0.75
New paradigms for the Hedgehog signaling network in mammary gland development and breast Cancer. Biochim Biophys Acta (2017) 0.75
Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression. Am J Cancer Res (2017) 0.75
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett (2017) 0.75
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell (2009) 12.96
Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene (2010) 9.66
The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res (2008) 7.65
Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res (1997) 4.22
Identification of an amplified, highly expressed gene in a human glioma. Science (1987) 4.21
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland. J Cell Biol (2006) 3.24
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol (2008) 2.87
A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res (2009) 2.84
Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development (1999) 2.77
Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene (2011) 2.73
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A (2010) 2.46
Cancer stem cells and self-renewal. Clin Cancer Res (2010) 2.37
NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene (2011) 2.22
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle (2007) 2.16
Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res (2011) 1.96
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer (2011) 1.75
Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. Proc Natl Acad Sci U S A (2004) 1.66
Epithelial-mesenchymal transition: a hallmark in metastasis formation linking circulating tumor cells and cancer stem cells. Pathobiology (2012) 1.43
Prognostic and predictive factors in breast cancer. Cancer Treat Rev (2001) 1.38
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med (2013) 1.33
Effects of estrogen on the proportion of stem cells in the breast. Breast Cancer Res Treat (2010) 1.31
The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective. Cancer Manag Res (2013) 1.22
Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast Cancer Res (2013) 1.02
Resistance to endocrine therapy: are breast cancer stem cells the culprits? J Mammary Gland Biol Neoplasia (2009) 1.02
Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem (2010) 1.00
Cancer stem cells and EMT in carcinoma. Cancer Metastasis Rev (2012) 0.95
Breast cancer stem cells and their role in resistance to endocrine therapy. Horm Cancer (2011) 0.95
Stem cells: their role in breast cancer development and resistance to treatment. Curr Pharm Biotechnol (2011) 0.95
CD44 is associated with the aggressive phenotype of nasopharyngeal carcinoma through redox regulation. Int J Mol Sci (2013) 0.86
Expression of Gli1 correlates with the transition of breast cancer cells to estrogen-independent growth. Breast Cancer Res Treat (2009) 0.84
Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1. Oncol Rep (2013) 0.80
Sequential deposition as a route to high-performance perovskite-sensitized solar cells. Nature (2013) 7.52
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell (2011) 6.23
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med (2008) 4.58
How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys (2010) 4.14
An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev Cell (2007) 3.46
Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis. Hepatology (2011) 3.38
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
Observation of conducting filament growth in nanoscale resistive memories. Nat Commun (2012) 3.02
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A (2013) 2.95
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies. Diabetes (2007) 2.91
Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors. Nat Cell Biol (2009) 2.76
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol (2011) 2.75
Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis (2011) 2.59
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. J Lipid Res (2005) 2.56
Open mesh techniques for inguinal hernia repair: a meta-analysis of randomized controlled trials. Ann Surg (2009) 2.44
PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1. Nat Cell Biol (2011) 2.28
B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer (2006) 2.27
Mesoscopic CH3NH3PbI3/TiO2 heterojunction solar cells. J Am Chem Soc (2012) 2.17
A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res (2007) 2.13
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing. Ann Neurol (2011) 2.11
Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther (2010) 2.09
Baseline serum lactate dehydrogenase levels for patients treated with intensity-modulated radiotherapy for nasopharyngeal carcinoma: a predictor of poor prognosis and subsequent liver metastasis. Int J Radiat Oncol Biol Phys (2011) 1.99
Alcohol consumption and visual impairment in a rural Northern Chinese population. Ophthalmic Epidemiol (2014) 1.98
Is the seventh edition of the UICC/AJCC TNM staging system reasonable for patients with tumor deposits in colorectal cancer? Ann Surg (2012) 1.87
Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans. Vaccine (2005) 1.79
A general approach to site-specific antibody drug conjugates. Proc Natl Acad Sci U S A (2014) 1.77
Is primary tumor volume still a prognostic factor in intensity modulated radiation therapy for nasopharyngeal carcinoma? Radiother Oncol (2012) 1.72
Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. Blood (2009) 1.70
CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis. Hepatology (2015) 1.70
Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J (2006) 1.69
Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients. J Clin Rheumatol (2009) 1.64
Tumor-induced osteomalacia: an important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature. J Bone Miner Res (2012) 1.63
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci U S A (2014) 1.62
The seventh edition of the UICC/AJCC staging system for nasopharyngeal carcinoma is prognostically useful for patients treated with intensity-modulated radiotherapy from an endemic area in China. Radiother Oncol (2011) 1.60
Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications. J Am Chem Soc (2009) 1.59
Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. Cancer Res (2013) 1.58
SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One (2008) 1.58
Co-suppression of MDR1 (multidrug resistance 1) and GCS (glucosylceramide synthase) restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi). Cancer Biol Ther (2009) 1.56
A single-sample microarray normalization method to facilitate personalized-medicine workflows. Genomics (2012) 1.55
Domain dynamics during ferroelectric switching. Science (2011) 1.51
MMP-9 and IL-6 are potential biomarkers for disease activity in Takayasu's arteritis. Int J Cardiol (2012) 1.51
Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Crit Care (2007) 1.50
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res (2013) 1.48
Exogenous surfactant may improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome: a meta-analysis of 9 clinical trials. J Cardiothorac Vasc Anesth (2012) 1.47
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol (2004) 1.46
Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway. J Neurochem (2013) 1.46
The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma: analysis of the spread patterns in lymph nodes by magnetic resonance imaging. Cancer (2009) 1.45
Extension of local disease in nasopharyngeal carcinoma detected by magnetic resonance imaging: improvement of clinical target volume delineation. Int J Radiat Oncol Biol Phys (2009) 1.45
How does magnetic resonance imaging influence staging according to AJCC staging system for nasopharyngeal carcinoma compared with computed tomography? Int J Radiat Oncol Biol Phys (2008) 1.44
Roles of PSF protein and VL30 RNA in reversible gene regulation. Proc Natl Acad Sci U S A (2005) 1.43
Highly efficient extraction of serum peptides by ordered mesoporous carbon. Angew Chem Int Ed Engl (2011) 1.43
The N staging system in nasopharyngeal carcinoma with radiation therapy oncology group guidelines for lymph node levels based on magnetic resonance imaging. Clin Cancer Res (2008) 1.41
Drug-loaded, magnetic, hollow silica nanocomposites for nanomedicine. Nanomedicine (2005) 1.38
Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells. J Med Chem (2008) 1.37
Mixed-organic-cation perovskite photovoltaics for enhanced solar-light harvesting. Angew Chem Int Ed Engl (2014) 1.37
Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology (2009) 1.36
Problematic Internet use in Chinese adolescents and its relation to psychosomatic symptoms and life satisfaction. BMC Public Health (2011) 1.34
Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. J Lipid Res (2009) 1.34
Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma detected by magnetic resonance imaging : prognostic value and staging categories. Cancer (2008) 1.33
Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. Biochemistry (2008) 1.32
Re-evaluation of 6th edition of AJCC staging system for nasopharyngeal carcinoma and proposed improvement based on magnetic resonance imaging. Int J Radiat Oncol Biol Phys (2009) 1.29
Comparative genome analysis of lignin biosynthesis gene families across the plant kingdom. BMC Bioinformatics (2009) 1.29
Characterization of a heart-specific fatty acid transport protein. J Biol Chem (2003) 1.28
Prognostic value of subclassification using MRI in the t4 classification nasopharyngeal carcinoma intensity-modulated radiotherapy treatment. Int J Radiat Oncol Biol Phys (2012) 1.28
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov (2013) 1.27
Prenatal life events stress: implications for preterm birth and infant birthweight. Am J Obstet Gynecol (2010) 1.27
Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem (2003) 1.26
Altered architecture and enhanced drought tolerance in rice via the down-regulation of indole-3-acetic acid by TLD1/OsGH3.13 activation. Plant Physiol (2009) 1.25
MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma. Cancer Lett (2012) 1.23
Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res (2010) 1.22
MiR-410 regulates MET to influence the proliferation and invasion of glioma. Int J Biochem Cell Biol (2012) 1.22
NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. Exp Cell Res (2009) 1.21
Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets. Vaccine (2011) 1.20
Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. J Biol Chem (2006) 1.20
A nerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells. Biomaterials (2010) 1.20
Imbalanced intrahepatic cytokine expression of interferon-gamma, tumor necrosis factor-alpha, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection. J Clin Gastroenterol (2009) 1.20
Locoregional extension patterns of nasopharyngeal carcinoma and suggestions for clinical target volume delineation. Chin J Cancer (2012) 1.20
Increased expression of miR-148b in ovarian carcinoma and its clinical significance. Mol Med Rep (2012) 1.18
Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia. Front Biosci (2007) 1.18
FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression. J Exp Med (2010) 1.17
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Res (2013) 1.16
Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med (2010) 1.15
The role of uPAR in epithelial-mesenchymal transition in small airway epithelium of patients with chronic obstructive pulmonary disease. Respir Res (2013) 1.15
A study of the interaction between malachite green and lysozyme by steady-state fluorescence. J Fluoresc (2009) 1.14
Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol (2005) 1.13
AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett (2011) 1.13
microRNA-192, -194 and -215 are frequently downregulated in colorectal cancer. Exp Ther Med (2011) 1.12
Simultaneous detection and identification of Candida, Aspergillus, and Cryptococcus species by reverse line blot hybridization. J Clin Microbiol (2006) 1.12
A coiled-coil- and C2-domain-containing protein is required for FAZ assembly and cell morphology in Trypanosoma brucei. J Cell Sci (2011) 1.12
Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction. Hypertension (2005) 1.12
Subclinical brain injury caused by H5N1 influenza virus infection. J Virol (2011) 1.11
SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res (2011) 1.11
Characterization of Gpr101 expression and G-protein coupling selectivity. Brain Res (2006) 1.11
A four-miRNA signature identified from genome-wide serum miRNA profiling predicts survival in patients with nasopharyngeal carcinoma. Int J Cancer (2013) 1.10
4,4,5,5-Tetra-methyl-2-(3,4,5-trimethoxy-phen-yl)imidazolidine-1-oxyl 3-oxide. Acta Crystallogr Sect E Struct Rep Online (2009) 1.10
Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem (2009) 1.10
Prognostic value and staging categories of anatomic masticator space involvement in nasopharyngeal carcinoma: a study of 924 cases with MR imaging. Radiology (2010) 1.10
A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation. Cancer Res (2013) 1.09