Epithelial-mesenchymal transitions in development and disease.

Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34

Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol (2014) 10.04

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene (2010) 9.66

Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37

TGFβ signalling in context. Nat Rev Mol Cell Biol (2012) 8.08

A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44

Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13

MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol (2010) 5.44

Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44

TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev (2010) 4.75

The Hippo pathway: regulators and regulations. Genes Dev (2013) 4.55

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51

VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell (2012) 4.47

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol (2011) 4.06

The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer? EMBO Rep (2010) 4.05

Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol (2010) 4.04

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell (2012) 4.01

The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96

The many faces and functions of β-catenin. EMBO J (2012) 3.85

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82

Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol (2011) 3.68

Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68

Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev (2013) 3.63

Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61

To differentiate or not--routes towards metastasis. Nat Rev Cancer (2012) 3.59

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res (2012) 3.48

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest (2012) 3.45

Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res (2010) 3.40

Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol (2011) 3.36

Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (2013) 3.32

CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell (2011) 3.31

Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet (2011) 3.27

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med (2012) 3.21

Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell (2012) 3.19

Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00

Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer (2010) 2.94

MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res (2010) 2.83

Classifying collective cancer cell invasion. Nat Cell Biol (2012) 2.83

Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82

MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer (2012) 2.78

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin Cancer Biol (2010) 2.75

Tumor metastasis: moving new biological insights into the clinic. Nat Med (2013) 2.71

EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature (2013) 2.70

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59

Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov (2014) 2.55

EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Cancer Cell (2011) 2.54

An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell (2011) 2.49

Origins of metastatic traits. Cancer Cell (2013) 2.49

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev (2011) 2.48

Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Reports (2013) 2.47

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem (2011) 2.46

Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol (2012) 2.46

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest (2011) 2.43

Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene (2011) 2.42

An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J (2010) 2.42

TGF-β Tumor Suppression through a Lethal EMT. Cell (2016) 2.37

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. Blood (2012) 2.35

Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell (2013) 2.34

Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev (2012) 2.31

Decoding the regulatory network of early blood development from single-cell gene expression measurements. Nat Biotechnol (2015) 2.30

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J (2011) 2.29

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev (2010) 2.27

Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res (2011) 2.26

Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat Med (2012) 2.24

The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res (2011) 2.21

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol (2011) 2.19

Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer. Br J Cancer (2011) 2.19

Epithelial junctions maintain tissue architecture by directing planar spindle orientation. Nature (2013) 2.17

Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol (2010) 2.15

Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am J Pathol (2011) 2.15

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer (2011) 2.14

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12

The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (2010) 2.12

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med (2015) 2.12

Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell (2013) 2.08

Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.07

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A (2011) 2.06

miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J Biol Chem (2010) 2.05

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J (2010) 2.04

Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater (2015) 2.02

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2014) 2.01

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest (2014) 2.01

Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res (2012) 2.00

Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell (2014) 1.99

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance. Drug Resist Updat (2010) 1.98

Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res (2012) 1.97

Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev (2012) 1.96

Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res (2011) 1.96

The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol (2010) 1.96

A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas. Br J Cancer (2011) 1.95

A systems view of epithelial-mesenchymal transition signaling states. Clin Exp Metastasis (2010) 1.95

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria. Kidney Int (2011) 1.94

The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell (2012) 5.53

Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene (2002) 4.20

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med (2009) 3.05

Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes. Mol Cancer Res (2002) 2.01

Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition. Trends Cell Biol (2008) 1.82

Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development (2003) 1.74

In situ hybridization analysis of chick embryos in whole-mount and tissue sections. Methods Cell Biol (2008) 1.51

Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J Cell Sci (2004) 1.50

Overexpression of Snail family members highlights their ability to promote chick neural crest formation. Development (2002) 1.45

The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells. Development (2007) 1.42

The physiology and pathology of the EMT. Meeting on the epithelial-mesenchymal transition. EMBO Rep (2008) 1.36

The class I bHLH factors E2-2A and E2-2B regulate EMT. J Cell Sci (2009) 1.34

LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest. Development (2004) 1.29

Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26

Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (2007) 1.23

Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev Cell (2007) 1.19

Snail family members and cell survival in physiological and pathological cleft palates. Dev Biol (2004) 1.17

Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proc Natl Acad Sci U S A (2002) 1.15

Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes. J Cell Sci (2010) 1.14

Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia. Am J Med Genet A (2010) 1.14

Evolutionary history of the Snail/Scratch superfamily. Trends Genet (2009) 1.13

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. J Cell Sci (2009) 1.12

Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle (2007) 1.03

Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J (2009) 1.00

How to become neural crest: from segregation to delamination. Semin Cell Dev Biol (2005) 0.98

Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. Dev Cell (2011) 0.98

Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice. Kidney Int (2009) 0.97

Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo. Dev Dyn (2004) 0.95

Ectopic expression of Cvh (Chicken Vasa homologue) mediates the reprogramming of chicken embryonic stem cells to a germ cell fate. Dev Biol (2009) 0.95

Induced pluripotent stem cells derived from rabbits exhibit some characteristics of naïve pluripotency. Biol Open (2013) 0.93

Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A. J Cell Sci (2009) 0.92

Biological potential of a functional human SNAIL retrogene. J Biol Chem (2002) 0.92

The expression of Scratch genes in the developing and adult brain. Dev Dyn (2006) 0.90

A new regulatory loop in cancer-cell invasion. EMBO Rep (2008) 0.86

A celebration of the new head and an evaluation of the new mouth. Neuron (2003) 0.86

The endogenous retrovirus ENS-1 provides active binding sites for transcription factors in embryonic stem cells that specify extra embryonic tissue. Retrovirology (2012) 0.84

eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex. Cell Rep (2013) 0.83

Expression of chicken slug and snail in mesenchymal components of the developing central nervous system. Dev Dyn (2004) 0.82

Evolution of the neural crest. Adv Exp Med Biol (2006) 0.81

Snail genes at the crossroads of symmetric and asymmetric processes in the developing mesoderm. EMBO Rep (2006) 0.81

Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family. Dev Genes Evol (2003) 0.80

Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons. J Neurosci (2013) 0.79

Epithelial plasticity, stemness and pluripotency. Cell Res (2010) 0.79

Expression of EphA receptors and ligands during chick cerebellar development. Mech Dev (2002) 0.78

[The "Snail" genes and renal diseases: what we learn from organogenesis]. Med Sci (Paris) (2008) 0.77

Jawsfest: new perspectives on neural crest lineages and morphogenesis. Development (2003) 0.76

An epigenetic mark that protects the epithelial phenotype in health and disease. Cell Stem Cell (2011) 0.76

Erratum: Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med (2016) 0.75

Mutual exclusion of transcription factors and cell behaviour in the definition of vertebrate embryonic territories. Curr Opin Genet Dev (2012) 0.75

Riding the right wave: would the real neural crest please stand up? Evol Dev (2008) 0.75