Published in Stem Cell Res Ther on June 10, 2014
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. J Extracell Vesicles (2015) 1.30
Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming. Stem Cell Res Ther (2015) 1.09
Exosomes/miRNAs as mediating cell-based therapy of stroke. Front Cell Neurosci (2014) 1.03
Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. Mol Ther (2015) 1.02
Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies. BMC Med (2015) 0.91
Mechanisms of mesenchymal stem/stromal cell function. Stem Cell Res Ther (2016) 0.88
Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release (2015) 0.86
Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche. Stem Cells Int (2016) 0.85
Extracellular Vesicles: Evolving Factors in Stem Cell Biology. Stem Cells Int (2015) 0.84
Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions. Sci Rep (2016) 0.83
Exosomes in liver pathology. J Hepatol (2016) 0.83
Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application. Front Physiol (2016) 0.83
Exosome and Microvesicle-Enriched Fractions Isolated from Mesenchymal Stem Cells by Gradient Separation Showed Different Molecular Signatures and Functions on Renal Tubular Epithelial Cells. Stem Cell Rev (2017) 0.83
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy. Chin J Cancer (2015) 0.82
Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles. Int J Mol Sci (2016) 0.82
MSCs-Derived Exosomes: Cell-Secreted Nanovesicles with Regenerative Potential. Front Pharmacol (2016) 0.82
Hepatic Stellate Cell-Derived Microvesicles Prevent Hepatocytes from Injury Induced by APAP/H2O2. Stem Cells Int (2016) 0.80
Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases. Expert Opin Biol Ther (2016) 0.79
Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model. Sci Rep (2015) 0.78
Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair. Stem Cell Res Ther (2015) 0.78
Exosomes as Tools to Suppress Primary Brain Tumor. Cell Mol Neurobiol (2016) 0.77
Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury. Redox Biol (2015) 0.77
Acellular approaches for regenerative medicine: on the verge of clinical trials with extracellular membrane vesicles? Stem Cell Res Ther (2015) 0.76
Exosomes as miRNA Carriers: Formation-Function-Future. Int J Mol Sci (2016) 0.76
Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation. J Cell Mol Med (2017) 0.75
Regenerative medicine using dental pulp stem cells for liver diseases. World J Gastrointest Pharmacol Ther (2017) 0.75
Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure. Stem Cell Res Ther (2017) 0.75
Stem Cell Extracellular Vesicles: Extended Messages of Regeneration. Annu Rev Pharmacol Toxicol (2016) 0.75
Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy. Stem Cell Res Ther (2017) 0.75
hucMSC Exosome-Derived GPX1 Is Required for the Recovery of Hepatic Oxidant Injury. Mol Ther (2017) 0.75
Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells. J Extracell Vesicles (2017) 0.75
CCR2 Positive Exosome Released by Mesenchymal Stem Cells Suppresses Macrophage Functions and Alleviates Ischemia/Reperfusion-Induced Renal Injury. Stem Cells Int (2016) 0.75
Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles. Int J Mol Sci (2017) 0.75
The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury. Stem Cell Res Ther (2017) 0.75
Exosomal MicroRNAs Derived From Umbilical Mesenchymal Stem Cells Inhibit Hepatitis C Virus Infection. Stem Cells Transl Med (2016) 0.75
The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration. Int J Biol Sci (2016) 0.75
Extracellular vesicles in liver diseases. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets. Nat Rev Gastroenterol Hepatol (2017) 0.75
Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents. Int J Mol Sci (2017) 0.75
Liver Regeneration: Analysis of the Main Relevant Signaling Molecules. Mediators Inflamm (2017) 0.75
Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine. Int J Mol Sci (2017) 0.75
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol (2007) 37.10
Shedding microvesicles: artefacts no more. Trends Cell Biol (2009) 8.84
Liver regeneration. Hepatology (2006) 7.52
Drug-related hepatotoxicity. N Engl J Med (2006) 7.49
Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci (2011) 5.42
Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci U S A (1997) 4.33
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res (2010) 4.06
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity (1996) 3.66
Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Invest (2003) 3.02
Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res (1989) 2.71
Surveillance for acute viral hepatitis - United States, 2007. MMWR Surveill Summ (2009) 2.69
Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J (2004) 2.30
Mesenchymal stem cells: progress toward promise. Cytotherapy (2005) 2.19
Hepatic stem cells in liver regeneration. FASEB J (1996) 2.07
Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Pharmacol Exp Ther (2004) 1.97
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc Natl Acad Sci U S A (1993) 1.71
Selective protein covalent binding and target organ toxicity. Toxicol Appl Pharmacol (1997) 1.66
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J Clin Invest (2005) 1.63
Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice. Toxicol Appl Pharmacol (1988) 1.58
Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics (2007) 1.51
Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model. PLoS One (2011) 1.43
Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem (2002) 1.42
Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation. Cell Growth Differ (1999) 1.37
Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome. Int J Proteomics (2012) 1.36
Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int (2008) 1.31
Proliferative effects of CXC chemokines in rat hepatocytes in vitro and in vivo. Shock (1998) 1.22
Mitogenic properties of endogenous and pharmacological doses of macrophage inflammatory protein-2 after 70% hepatectomy in the mouse. Am J Pathol (2003) 1.21
CXC chemokines play a critical role in liver injury, recovery, and regeneration. Am J Surg (2009) 1.16
Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles. J Mol Cell Cardiol (2010) 1.13
Autonomous growth in serum-free medium and production of hepatocellular carcinomas by differentiated hepatocyte lines that overexpress transforming growth factor alpha 1. Cancer Res (1994) 1.11
Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. Am J Physiol (1997) 1.10
Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD. J Hepatol (2004) 1.03
Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration. J Biol Chem (2008) 1.02
Nitric oxide is released in regenerating liver after partial hepatectomy. Hepatology (1995) 0.96
Hepatocyte growth factor/scatter factor, liver regeneration and cancer metastasis. Br J Surg (1993) 0.95
Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening. Chem Res Toxicol (2007) 0.94
Role of mitochondrial dysfunction in hydrogen peroxide-induced apoptosis of intestinal epithelial cells. World J Gastroenterol (2003) 0.89
New insights into liver regeneration. Clin Res Hepatol Gastroenterol (2011) 0.89
Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats. J Biochem (1995) 0.88
Cytokine expression in hepatocytes: role of oxidant stress. J Interferon Cytokine Res (1998) 0.87
IL-6, a key cytokine in liver regeneration. Hepatology (1997) 0.85
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med (2013) 7.48
Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state. Stem Cells (2005) 3.16
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucleic Acids Res (2009) 2.66
Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells (2006) 2.11
Management of chronic hepatitis C: consensus guidelines. Can J Gastroenterol (2007) 2.06
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics (2010) 1.97
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res (2013) 1.96
Management of chronic hepatitis B: consensus guidelines. Can J Gastroenterol (2007) 1.78
Myocardial infarction in the C57BL/6J mouse: a quantifiable and highly reproducible experimental model. Cardiovasc Pathol (2004) 1.67
Intragastric balloon significantly improves nonalcoholic fatty liver disease activity score in obese patients with nonalcoholic steatohepatitis: a pilot study. Gastrointest Endosc (2012) 1.55
Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics (2007) 1.51
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem Cell Res (2011) 1.50
Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. Adv Drug Deliv Rev (2012) 1.38
Mesenchymal stem cells secrete immunologically active exosomes. Stem Cells Dev (2014) 1.30
Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med (2011) 1.29
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Biochem Biophys Res Commun (2009) 1.20
Carbon nanotubes for delivery of small molecule drugs. Adv Drug Deliv Rev (2013) 1.18
CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis. Cell Cycle (2008) 1.12
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. Hepatology (2008) 1.08
Bioactivation and hepatotoxicity of nitroaromatic drugs. Curr Drug Metab (2006) 1.07
Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Mol Pharmacol (2010) 1.05
Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. Cancer Res (2007) 1.04
Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: a meta-analysis. Cancer Treat Rev (2012) 0.97
Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening. Chem Res Toxicol (2007) 0.94
Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering. Biotechnol Adv (2012) 0.93
Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes. FEBS Lett (2002) 0.93
Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation. Free Radic Biol Med (2003) 0.91
AFP(+), ESC-derived cells engraft and differentiate into hepatocytes in vivo. Stem Cells (2002) 0.90
Complexity and health coaching: synergies in nursing. Nurs Res Pract (2013) 0.89
Cytokines as mediators of chemotherapy-associated cognitive changes: current evidence, limitations and directions for future research. PLoS One (2013) 0.89
Role of sunitinib and SU12662 on dermatological toxicities in metastatic renal cell carcinoma patients: in vitro, in vivo, and outcomes investigation. Cancer Chemother Pharmacol (2013) 0.89
Recovery of locked-in syndrome following liver transplantation with calcineurin inhibitor cessation and supportive treatment. Am J Case Rep (2013) 0.88
Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence. Breast Cancer Res Treat (2012) 0.88
Vascular endothelial growth factor inhibitors and cognitive impairment: evidence and controversies. Expert Opin Drug Saf (2013) 0.87
An investigation of the bioactivation potential and metabolism profile of Zebrafish versus human. J Biomol Screen (2012) 0.87
Controlled delivery of heat shock protein using an injectable microsphere/hydrogel combination system for the treatment of myocardial infarction. J Control Release (2009) 0.87
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint. J Biol Chem (2008) 0.87
Rapid determination of vertebral fat fraction over a large range of vertebral bodies. J Med Imaging Radiat Oncol (2013) 0.85
Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review. Expert Opin Drug Metab Toxicol (2014) 0.85
Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma. Mol Cancer (2012) 0.85
Investigating the role of nucleoside transporters in the resistance of colorectal cancer to 5-fluorouracil therapy. Cancer Chemother Pharmacol (2012) 0.83
Metabolism-related pharmacokinetic drug-drug interactions with tyrosine kinase inhibitors: current understanding, challenges and recommendations. Br J Clin Pharmacol (2015) 0.83
Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin. Biomaterials (2013) 0.82
Cholangiocarcinoma: has there been any progress? Can J Gastroenterol (2010) 0.82
Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner. FEBS Lett (2003) 0.82
Ultrasound biomicroscopy of the anterior segment of the enucleated chicken eye during accommodation. Ophthalmic Physiol Opt (2002) 0.81
Whole bone marrow transplantation induces angiogenesis following acute ischemia. Redox Rep (2002) 0.81
GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease. J Alzheimers Dis (2013) 0.81
Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus. Diabetes Metab Res Rev (2005) 0.80
Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.80
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. Gastroenterology (2009) 0.80
A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B. Antivir Ther (2006) 0.80
Incremental changes verses a technological quantum leap: the additional value of intensity-modulated radiotherapy beyond image-guided radiotherapy for prostate irradiation. J Med Imaging Radiat Oncol (2014) 0.79
Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes. Toxicol Lett (2010) 0.79
Embryonic cell lines with endothelial potential: an in vitro system for studying endothelial differentiation. Arterioscler Thromb Vasc Biol (2004) 0.79
Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity. Toxicol Lett (2009) 0.79
Interaction of lapatinib with cytochrome P450 3A5. Drug Metab Dispos (2012) 0.78
Health care costs of persons with newly diagnosed hepatitis C virus: a population-based, observational study. J Viral Hepat (2008) 0.78
Do different lamivudine-resistant hepatitis B genotypes carry the same risk of entecavir resistance? J Med Virol (2012) 0.77
The incidence and prevalence of diabetes in patients with serious mental illness in North West Wales: two cohorts, 1875-1924 & 1994-2006 compared. BMC Psychiatry (2008) 0.77
Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties. Eur J Pharmacol (2012) 0.77
Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis. J Clin Gastroenterol (2011) 0.77
Labour force participation among individuals with hepatitis C in the US. Pharmacoeconomics (2003) 0.77
PI3 K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell lines. J Mol Signal (2007) 0.77
Establishing clonal cell lines with endothelial-like potential from CD9(hi), SSEA-1(-) cells in embryonic stem cell-derived embryoid bodies. PLoS One (2006) 0.77
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease. J Med Chem (2015) 0.76
Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury. Exp Brain Res (2002) 0.76
Association of drug exposure with toxicity and clinical response in metastatic renal cell carcinoma patients receiving an attenuated dosing regimen of sunitinib. Target Oncol (2014) 0.76
Prevalence and Outcome of Upper Gastrointestinal Bleeding Post-coronary Artery Bypass Graft. Int J Health Sci (Qassim) (2008) 0.75
Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance. World J Gastroenterol (2010) 0.75
Bioengineering the artificial liver with non-hepatic cells: where are we headed? J Gastroenterol Hepatol (2009) 0.75
Acute management and secondary prophylaxis of esophageal variceal bleeding: a western Canadian survey. Can J Gastroenterol (2006) 0.75
Liver disease progression and virological response: entecavir rescue still possible in the setting of rtM204I lamivudine-resistant mutation. Gut (2012) 0.75
Transplantation of autologous bone marrow-derived cells into the myocardium of patients undergoing coronary bypass. Heart Surg Forum (2005) 0.75
Applicability of cost-effectiveness analysis to management of chronic hepatitis B. J Gastroenterol Hepatol (2007) 0.75
Immobilisation of quantum dots by bio-orthogonal PCR amplification and labelling for direct gene detection and quantitation. Chem Commun (Camb) (2012) 0.75
Blood pressure measurement in noise intensive environments using adaptive interference cancellation. Ann Biomed Eng (2002) 0.75
Mitochondria-acting hexokinase II peptides carried by short-length carbon nanotubes with increased cellular uptake, endosomal evasion, and enhanced bioactivity against cancer cells. Nanoscale (2015) 0.75
Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis. Analyst (2017) 0.75
Generation of hybrid cell lines with endothelial potential from spontaneous fusion of adult bone marrow cells with embryonic fibroblast feeder. In Vitro Cell Dev Biol Anim (2004) 0.75
Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation. Toxicol Lett (2011) 0.75