Published in Genetics on June 14, 2014
A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction. Elife (2015) 0.98
Genetic architecture of colorectal cancer. Gut (2015) 0.97
Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex. Mol Biol Cell (2014) 0.84
Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol (2015) 0.78
The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2. J Biol Chem (2016) 0.78
Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome. Cancers (Basel) (2016) 0.77
Regulatory single nucleotide polymorphisms (rSNPs) at the promoters 1A and 1B of the human APC gene. BMC Genet (2016) 0.75
Reconstituting regulation of the canonical Wnt pathway by engineering a minimal βcatenin destruction machine. Mol Biol Cell (2016) 0.75
The cell survival pathways of the primordial RNA-DNA complex remain conserved in the extant genomes and may function as proto-oncogenes. Eur J Microbiol Immunol (Bp) (2015) 0.75
The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling. Mol Biol Cell (2015) 0.75
The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma. Einstein (Sao Paulo) (2016) 0.75
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An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A (2007) 12.13
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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science (2007) 5.45
wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development (1994) 4.04
beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene (2006) 3.43
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03
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Wnt signaling in cancer. Cold Spring Harb Perspect Biol (2012) 2.75
The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum Mol Genet (2002) 2.69
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Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J Biol Chem (1999) 2.38
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J Cell Biol (1999) 2.36
Wnt signaling in stem and cancer stem cells. Curr Opin Cell Biol (2013) 2.35
Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol (2004) 2.33
ovo/svb integrates Wingless and DER pathways to control epidermis differentiation. Nature (1999) 2.32
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Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J Cell Biol (1999) 2.04
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Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res (1997) 1.91
Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci (2007) 1.87
Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell (1998) 1.82
Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention. J Cell Sci (2006) 1.78
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A new Drosophila APC homologue associated with adhesive zones of epithelial cells. Nat Cell Biol (1999) 1.66
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. Oncogene (2000) 1.62
APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. Mol Cell (2008) 1.54
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies. Science (2013) 1.43
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43
Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development (2002) 1.41
Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development (2006) 1.37
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun (2013) 1.34
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. Mol Cell (2004) 1.29
Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. Dev Biol (2002) 1.27
Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr Biol (2010) 1.24
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol Biol Cell (2011) 1.21
Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature (1994) 1.20
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr Biol (1999) 1.19
Wnt signaling in bone development and disease: making stronger bone with Wnts. Cold Spring Harb Perspect Biol (2012) 1.18
Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo. Dev Biol (2008) 1.18
Wnt signaling in the vertebrate central nervous system: from axon guidance to synaptic function. Cold Spring Harb Perspect Biol (2012) 1.18
The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J Mol Biol (2006) 1.13
Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3. Biochemistry (2007) 1.06
Wnt signaling in vertebrate axis specification. Cold Spring Harb Perspect Biol (2013) 1.03
Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. Hum Mol Genet (2008) 0.98
Engrailed and hedgehog make the range of Wingless asymmetric in Drosophila embryos. Cell (1999) 0.94
α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes. Genes Dev (2013) 0.93
A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. PLoS One (2012) 0.93
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization. Mol Biol Cell (2012) 0.92
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation. PLoS One (2013) 0.90
Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. J Cell Sci (2011) 0.89
Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. Oncogene (2009) 0.84
Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo. Genetics (2011) 0.84
Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. PLoS One (2012) 0.82
different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli. PLoS One (2014) 0.80
Regulation of the phosphorylation and nuclear import and export of β-catenin by APC and its cancer-related truncated form. J Cell Sci (2014) 0.79