Published in Redox Biol on March 26, 2014
LC-MS/MS suggests that hole hopping in cytochrome c peroxidase protects its heme from oxidative modification by excess H2O2. Chem Sci (2016) 0.77
Model systems of motor neuron diseases as a platform for studying pathogenic mechanisms and searching for therapeutic agents. Acta Naturae (2015) 0.75
Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1. Biophys J (2016) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Protein oxidation in aging, disease, and oxidative stress. J Biol Chem (1997) 7.35
The chronological life span of Saccharomyces cerevisiae. Aging Cell (2003) 3.98
Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Annu Rev Biochem (2005) 3.59
Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem (1996) 3.12
A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. J Biol Chem (2001) 3.01
Misfolded CuZnSOD and amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2003) 2.65
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis. J Biol Chem (2004) 2.36
Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction. J Biol Chem (2002) 1.96
Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. Proc Natl Acad Sci U S A (2004) 1.89
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (2013) 1.85
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells. Proc Natl Acad Sci U S A (2011) 1.82
Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. Free Radic Biol Med (2009) 1.82
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. J Biol Chem (2002) 1.80
Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc (2009) 1.74
Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form. Acta Neuropathol (2010) 1.49
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes. BMC Neurosci (2003) 1.46
Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? Nat Rev Neurosci (2010) 1.46
ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics. Hum Mutat (2012) 1.45
Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem (2005) 1.42
Identification of oxidized histidine generated at the active site of Cu,Zn-superoxide dismutase exposed to H2O2. Selective generation of 2-oxo-histidine at the histidine 118. J Biol Chem (1994) 1.30
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS. J Mol Biol (2007) 1.26
Yeast as a model to study mitochondrial mechanisms in ageing. Mech Ageing Dev (2010) 1.15
Import, maturation, and function of SOD1 and its copper chaperone CCS in the mitochondrial intermembrane space. Antioxid Redox Signal (2010) 1.12
Time line of redox events in aging postmitotic cells. Elife (2013) 1.10
Extensive investigations on oxidized amino acid residues in H(2)O(2)-treated Cu,Zn-SOd protein with LC-ESI-Q-TOF-MS, MS/MS for the determination of the copper-binding site. J Am Chem Soc (2001) 1.09
Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis. Proteins (2013) 1.05
Kinetic stability of Cu/Zn superoxide dismutase is dependent on its metal ligands: implications for ALS. Biochemistry (2004) 1.04
Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping: the role of copper- and carbonate radical anion-mediated oxidations. Free Radic Biol Med (2005) 1.02
Long-lived yeast as a model for ageing research. Yeast (2006) 0.97
Cytochrome c peroxidase is a mitochondrial heme-based H2O2 sensor that modulates antioxidant defense. Free Radic Biol Med (2013) 0.89
Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition. Redox Biol (2013) 0.89
Mutant superoxide dismutase-1 indistinguishable from wild-type causes ALS. Hum Mol Genet (2012) 0.87
Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma. Antioxid Redox Signal (2012) 0.86
Biological aging does not lead to the accumulation of oxidized Cu,Zn-superoxide dismutase in the liver of F344 rats. Free Radic Biol Med (2001) 0.85
Phenotypic analysis of the ccp1Delta and ccp1Delta-ccp1W191F mutant strains of Saccharomyces cerevisiae indicates that cytochrome c peroxidase functions in oxidative-stress signaling. J Inorg Biochem (2006) 0.84
Cells with impaired mitochondrial H2O2 sensing generate less •OH radicals and live longer. Antioxid Redox Signal (2014) 0.82
Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis. Biochem Soc Trans (2011) 0.79
Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate. Free Radic Biol Med (2012) 0.78
Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms. PLoS One (2013) 0.76