The pericyte: a forgotten cell type with important implications for Alzheimer's disease?

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMC 4423607)

Published in Brain Pathol on July 01, 2014

Authors

Ethan A Winkler1, Abhay P Sagare, Berislav V Zlokovic

Author Affiliations

1: Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, CA; Department of Neurosurgery, University of California San Francisco, San Francisco, CA.

Articles citing this

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Neuron (2015) 1.93

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest (2016) 1.39

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci (2015) 1.07

Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab (2016) 1.05

Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension (2016) 0.87

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J Cereb Blood Flow Metab (2015) 0.86

The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline. Cell Mol Neurobiol (2016) 0.85

Pericytes as targets in hereditary hemorrhagic telangiectasia. Front Genet (2015) 0.84

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta (2015) 0.82

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci (2017) 0.82

Brain and Retinal Pericytes: Origin, Function and Role. Front Cell Neurosci (2016) 0.81

Age-associated physiological and pathological changes at the blood-brain barrier: A review. J Cereb Blood Flow Metab (2016) 0.80

Vasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and Interventions. J Alzheimers Dis (2015) 0.77

Organotypic brain slice cultures as a model to study angiogenesis of brain vessels. Front Cell Dev Biol (2015) 0.77

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci (2017) 0.76

Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders. Ageing Res Rev (2016) 0.75

Molecular, Cellular, and Genetic Determinants of Sporadic Brain Arteriovenous Malformations. Neurosurgery (2016) 0.75

Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease. Sleep Med Rev (2016) 0.75

Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling. Front Physiol (2016) 0.75

Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology. Mol Cell Neurosci (2016) 0.75

Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer's disease. Neuro Oncol (2017) 0.75

Articles cited by this

(truncated to the top 100)

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science (1996) 19.72

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36

Alzheimer's disease. N Engl J Med (2010) 13.13

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA (1997) 10.75

Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med (2003) 10.61

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science (1997) 10.54

The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19

Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci (2004) 9.29

Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science (2010) 8.04

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci (2007) 7.96

Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development (1999) 7.12

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature (1996) 7.04

Pericytes regulate the blood-brain barrier. Nature (2010) 6.62

Glial and neuronal control of brain blood flow. Nature (2010) 6.61

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (2006) 6.47

The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell (2011) 6.12

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci (2011) 5.64

Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature (2010) 5.47

Bidirectional control of CNS capillary diameter by pericytes. Nature (2006) 5.27

Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron (2010) 5.20

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol (2001) 5.17

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med (2003) 5.14

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07

Viability thresholds and the penumbra of focal ischemia. Ann Neurol (1994) 4.49

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature (2009) 4.43

Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res (2003) 4.39

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron (2004) 4.29

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science (2010) 3.98

Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci (2005) 3.84

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80

Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler Thromb Vasc Biol (2009) 3.78

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci (2008) 3.78

Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis. Neurobiol Aging (2007) 3.63

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci (2010) 3.61

Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol (2001) 3.49

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest (2008) 3.36

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab (2006) 3.35

Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci (2009) 3.10

The pathobiology of vascular dementia. Neuron (2013) 3.07

APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42. J Neurosci (2010) 2.99

Central nervous system pericytes in health and disease. Nat Neurosci (2011) 2.90

Pericyte physiology. FASEB J (1993) 2.88

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med (2010) 2.88

Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol (2009) 2.85

beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature (1996) 2.82

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 2.81

Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol (2005) 2.80

The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain. Development (2001) 2.78

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med (2009) 2.76

Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol (2009) 2.74

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood (2009) 2.73

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J (2002) 2.73

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med (2005) 2.71

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell (1997) 2.68

Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol (2003) 2.57

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience (2008) 2.55

Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol (2006) 2.50

Synaptic energy use and supply. Neuron (2012) 2.40

Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease. Neuron (2010) 2.37

APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry (2011) 2.31

The genetics of Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.20

Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell (2011) 2.17

Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. J Nucl Med (2006) 2.17

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest (2011) 2.09

Altered glucose metabolism in microvessels from patients with Alzheimer's disease. Ann Neurol (1989) 2.08

Microvascular injury and blood-brain barrier leakage in Alzheimer's disease. Neurobiol Aging (2006) 2.03

RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease. Acta Neuropathol (2006) 1.94

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc Natl Acad Sci U S A (2010) 1.91

Review: cerebral microvascular pathology in ageing and neurodegeneration. Neuropathol Appl Neurobiol (2011) 1.91

Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med (2007) 1.91

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A (2007) 1.91

Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol (2003) 1.91

Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis (2003) 1.89

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol (2008) 1.83

Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain (2011) 1.82

Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization. Blood (2010) 1.81

Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease. Neurology (1999) 1.80

Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res (2005) 1.76

Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA Neurol (2013) 1.75

Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation (2003) 1.69

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. Genes Dev (2007) 1.68

Brain injury after intracerebral hemorrhage: the role of thrombin and iron. Stroke (2007) 1.68

Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease. J Neuroinflammation (2011) 1.68

New insights into the dementia epidemic. N Engl J Med (2013) 1.67

Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci U S A (2000) 1.66

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain (2013) 1.64

Pericytes: pluripotent cells of the blood brain barrier. Curr Pharm Des (2008) 1.63

Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan. Angiogenesis (2004) 1.62

Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. Eur J Clin Invest (2002) 1.61

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front Neuroenergetics (2010) 1.59

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J Cell Mol Med (2008) 1.58

Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke (2009) 1.57

Role of astrocytes in neurovascular coupling. Neuron (2011) 1.57

An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis. Angiogenesis (2007) 1.56

Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice. J Cereb Blood Flow Metab (2000) 1.55

Does vascular pathology contribute to Alzheimer changes? J Neurol Sci (2012) 1.52

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener (2010) 1.49

Articles by these authors

The cytoprotective protein C pathway. Blood (2006) 5.75

Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron (2010) 5.20

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron (2004) 4.29

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med (2003) 4.04

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci (2008) 3.78

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest (2008) 3.36

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab (2006) 3.35

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest (2012) 2.98

Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol (2009) 2.85

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 2.81

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med (2005) 2.71

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem (2004) 2.45

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med (2004) 2.45

Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med (2007) 2.32

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron (2004) 2.23

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med (2006) 2.22

Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res (2007) 2.17

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A (2007) 1.91

RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke (2004) 1.89

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol (2008) 1.83

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci (2005) 1.69

Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab (2007) 1.64

Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol (2008) 1.62

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener (2010) 1.49

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem (2010) 1.47

Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol (2012) 1.45

A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods (2003) 1.44

Neurodegeneration and the neurovascular unit. Nat Med (2010) 1.37

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood (2003) 1.37

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proc Natl Acad Sci U S A (2012) 1.34

Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci (2008) 1.33

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.32

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood (2010) 1.30

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci (2009) 1.30

Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathol (2012) 1.19

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods (2004) 1.19

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke (2012) 1.18

Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis (2003) 1.15

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke (2008) 1.15

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A (2014) 1.14

Protein C anticoagulant and cytoprotective pathways. Int J Hematol (2012) 1.14

Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J Cereb Blood Flow Metab (2012) 1.13

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance. Proc Natl Acad Sci U S A (2013) 1.11

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab (2008) 1.10

Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem (2004) 1.08

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis (2013) 1.07

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul Pharmacol (2002) 1.07

Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target (2002) 1.06

Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab (2016) 1.05

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol (2013) 1.04

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res (2010) 1.00

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci (2013) 1.00

Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact. Brain Res (2010) 1.00

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem (2009) 0.99

Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery (2010) 0.98

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des (2012) 0.98

Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica (2009) 0.96

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci (2010) 0.93

Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation (2003) 0.93

Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol (2002) 0.92

The promise of protein C. Blood Cells Mol Dis (2006) 0.92

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke (2013) 0.91

Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis (2011) 0.91

Remodeling after stroke. Nat Med (2006) 0.89

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res (2013) 0.89

Activated protein C and ischemic stroke. Crit Care Med (2004) 0.89

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener (2011) 0.88

Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther (2012) 0.85

Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost (2014) 0.84

Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab (2016) 0.84

Endothelial cell protein C receptor: role beyond endothelium? Circ Res (2007) 0.83

Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery (2003) 0.82

A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. J Biol Chem (2013) 0.82

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis (2013) 0.81

From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. J Neurosci Res (2011) 0.81

Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol (2005) 0.81

Clearance systems in the brain-implications for Alzheimer diseaser. Nat Rev Neurol (2016) 0.80

Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Dev Cell (2011) 0.80

Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotroph Lateral Scler (2011) 0.76