Published in Neuron on November 20, 2013
B-lymphocyte-mediated delayed cognitive impairment following stroke. J Neurosci (2015) 2.31
Blood-brain barrier breakdown in the aging human hippocampus. Neuron (2015) 2.17
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nat Commun (2014) 1.66
Establishment and Dysfunction of the Blood-Brain Barrier. Cell (2015) 1.30
What are white matter hyperintensities made of? Relevance to vascular cognitive impairment. J Am Heart Assoc (2015) 1.19
A critical role for the vascular endothelium in functional neurovascular coupling in the brain. J Am Heart Assoc (2014) 1.18
Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Proc Natl Acad Sci U S A (2015) 1.16
The overlap between vascular disease and Alzheimer's disease--lessons from pathology. BMC Med (2014) 1.15
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun (2015) 1.11
Recommendations of the Alzheimer's disease-related dementias conference. Neurology (2014) 1.05
Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front Aging Neurosci (2014) 1.02
Cardiovascular risk factors and future risk of Alzheimer's disease. BMC Med (2014) 1.00
The neuropathology and cerebrovascular mechanisms of dementia. J Cereb Blood Flow Metab (2016) 0.98
The role of autophagy in vascular biology. Circ Res (2015) 0.96
The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol (2014) 0.96
Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci (2016) 0.94
Binaural blood flow control by astrocytes: listening to synapses and the vasculature. J Physiol (2016) 0.91
Hypertension and dementia. Hypertension (2014) 0.91
Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment. Transl Stroke Res (2014) 0.91
Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation (2015) 0.91
Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke (2014) 0.89
Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease. Proc Natl Acad Sci U S A (2015) 0.87
Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension (2016) 0.87
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. J Cereb Blood Flow Metab (2016) 0.87
Hypoxia-induced neuroinflammatory white-matter injury reduced by minocycline in SHR/SP. J Cereb Blood Flow Metab (2015) 0.86
Microvascular Dysfunction and Cognitive Impairment. Cell Mol Neurobiol (2016) 0.86
Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J Cereb Blood Flow Metab (2015) 0.86
Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation. Hypertension (2014) 0.86
Neurobehavioral and imaging correlates of hippocampal atrophy in a mouse model of vascular cognitive impairment. Transl Stroke Res (2015) 0.86
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. Nat Commun (2016) 0.86
Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism. Hypertension (2014) 0.86
Astrocyte regulation of blood flow in the brain. Cold Spring Harb Perspect Biol (2015) 0.86
The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline. Cell Mol Neurobiol (2016) 0.85
Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. J Clin Invest (2016) 0.85
The role of pericytes in neurovascular unit remodeling in brain disorders. Int J Mol Sci (2014) 0.84
Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener (2015) 0.84
Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease. J Cereb Blood Flow Metab (2016) 0.84
Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab (2016) 0.84
Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer's disease. Front Aging Neurosci (2015) 0.84
Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review. J Cereb Blood Flow Metab (2016) 0.83
Micro-heterogeneity of flow in a mouse model of chronic cerebral hypoperfusion revealed by longitudinal Doppler optical coherence tomography and angiography. J Cereb Blood Flow Metab (2015) 0.83
Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain. J Alzheimers Dis (2015) 0.83
Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease. Oncoscience (2014) 0.82
On the central role of brain connectivity in neurodegenerative disease progression. Front Aging Neurosci (2015) 0.82
Tracer kinetic modelling for DCE-MRI quantification of subtle blood-brain barrier permeability. Neuroimage (2015) 0.82
High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion. J Cereb Blood Flow Metab (2015) 0.82
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta (2015) 0.82
DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests. Front Aging Neurosci (2014) 0.82
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci (2017) 0.82
Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion. Neuroimage (2014) 0.81
The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimer's Disease and Vascular Dementia. Oxid Med Cell Longev (2015) 0.81
Blood-brain barrier: a dual life of MFSD2A? Neuron (2014) 0.81
Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine. J Clin Med (2016) 0.81
White matter signal abnormality quality differentiates mild cognitive impairment that converts to Alzheimer's disease from nonconverters. Neurobiol Aging (2015) 0.81
Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice. Ann Neurol (2016) 0.80
Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease. J Cereb Blood Flow Metab (2015) 0.80
Role of soluble epoxide hydrolase in age-related vascular cognitive decline. Prostaglandins Other Lipid Mediat (2014) 0.80
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. Circ Res (2017) 0.80
Strategic lesions in the anterior thalamic radiation and apathy in early Alzheimer's disease. PLoS One (2015) 0.79
Genes influence the amplitude and timing of brain hemodynamic responses. Neuroimage (2015) 0.79
Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway. J Biol Chem (2015) 0.79
Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans. J Am Heart Assoc (2016) 0.79
Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Sci Rep (2015) 0.79
Fructus mume Ethanol Extract Prevents Inflammation and Normalizes the Septohippocampal Cholinergic System in a Rat Model of Chronic Cerebral Hypoperfusion. J Med Food (2015) 0.79
Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice. J Neurosci (2016) 0.79
Increased risk of dementia in patients hospitalized with acute kidney injury: A nationwide population-based cohort study. PLoS One (2017) 0.79
Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia. Acta Neuropathol Commun (2016) 0.78
Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling. Mol Brain (2016) 0.78
Rho kinase activity governs arteriolar myogenic depolarization. J Cereb Blood Flow Metab (2015) 0.78
An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease. Alzheimers Res Ther (2016) 0.78
Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aβ deposits: effect of immunoglobulin. Aging Dis (2014) 0.78
Binswanger's disease: toward a diagnosis agreement and therapeutic approach. Expert Rev Neurother (2014) 0.78
Can physical exercise in old age improve memory and hippocampal function? Brain (2016) 0.78
Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases. RNA (2014) 0.78
Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology. Biochim Biophys Acta (2015) 0.78
Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations. Cell Mol Neurobiol (2015) 0.78
Neuroimaging Assessment of Cerebrovascular Reactivity in Concussion: Current Concepts, Methodological Considerations, and Review of the Literature. Front Neurol (2016) 0.78
Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study. Alzheimer Dis Assoc Disord (2016) 0.78
Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology. Cell Metab (2015) 0.78
Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex. Am J Physiol Heart Circ Physiol (2015) 0.78
Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer's Disease. Cell Mol Neurobiol (2016) 0.78
Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment. Stroke (2017) 0.77
Comorbidity and dementia: A nationwide survey in Taiwan. PLoS One (2017) 0.77
Rodent Models of Vascular Cognitive Impairment. Transl Stroke Res (2016) 0.77
ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice. Sci Rep (2015) 0.77
Chronic administration of isocarbophos induces vascular cognitive impairment in rats. J Cell Mol Med (2016) 0.77
Transcranial direct current stimulation in post stroke aphasia and primary progressive aphasia: Current knowledge and future clinical applications. NeuroRehabilitation (2016) 0.77
NGF and TERT co-transfected BMSCs improve the restoration of cognitive impairment in vascular dementia rats. PLoS One (2014) 0.77
Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Exp Gerontol (2016) 0.77
Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neurosci Lett (2015) 0.77
The impact of cerebrovascular aging on vascular cognitive impairment and dementia. Ageing Res Rev (2016) 0.77
Aging-related alterations in eNOS and nNOS responsiveness and smooth muscle reactivity of murine basilar arteries are modulated by apocynin and phosphorylation of myosin phosphatase targeting subunit-1. J Cereb Blood Flow Metab (2016) 0.77
Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models. Mol Cell Neurosci (2014) 0.77
Vasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and Interventions. J Alzheimers Dis (2015) 0.77
Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease. Brain (2015) 0.77
Gout and the risk of dementia: a nationwide population-based cohort study. Arthritis Res Ther (2015) 0.77
Remote ischaemic conditioning-a new paradigm of self-protection in the brain. Nat Rev Neurol (2015) 0.77
Dangerous leaks: blood-brain barrier woes in the aging hippocampus. Neuron (2015) 0.77
Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes. Neuroimage (2015) 0.76
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology (1993) 16.92
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med (2003) 13.84
Molecular mechanisms and clinical applications of angiogenesis. Nature (2011) 13.36
Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med (2005) 12.03
Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA (1997) 10.75
The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci (2004) 9.29
Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology (2007) 9.27
Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science (2004) 9.10
Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science (2010) 8.04
Observations on the brains of demented old people. J Neurol Sci (1970) 6.99
Monetary costs of dementia in the United States. N Engl J Med (2013) 6.77
Pericytes regulate the blood-brain barrier. Nature (2010) 6.62
The immunology of stroke: from mechanisms to translation. Nat Med (2011) 6.53
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci (2008) 6.16
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci (2011) 5.64
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron (2010) 5.20
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07
The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol (2009) 4.96
Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol (2007) 4.87
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci (2008) 4.64
Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol (2009) 4.60
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol (2013) 4.29
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron (2004) 4.29
Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol (2012) 4.25
The neural basis of functional brain imaging signals. Trends Neurosci (2002) 4.01
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron (2007) 3.98
The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology (1995) 3.95
Multi-infarct dementia. A cause of mental deterioration in the elderly. Lancet (1974) 3.91
Cadasil. Lancet Neurol (2009) 3.88
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80
Spike timing-dependent plasticity of neural circuits. Neuron (2004) 3.76
Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. Ann Intern Med (2004) 3.66
Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol (2011) 3.56
Myelination and support of axonal integrity by glia. Nature (2010) 3.54
Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. J Neurosci (2002) 3.50
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer (2010) 3.48
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke (2006) 3.27
The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged. Arch Neurol (2009) 3.13
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov (2011) 3.08
What is immune privilege (not)? Trends Immunol (2006) 3.02
Leuko-araiosis. Arch Neurol (1987) 2.93
beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature (1996) 2.82
Incident lacunes influence cognitive decline: the LADIS study. Neurology (2011) 2.81
Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol (2005) 2.80
White matter lesions impair frontal lobe function regardless of their location. Neurology (2004) 2.77
Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center. Neurology (2005) 2.76
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest (2013) 2.66
Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons. Ann Neurol (2007) 2.66
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci U S A (2006) 2.66
Cognitive impact of subcortical vascular and Alzheimer's disease pathology. Ann Neurol (2006) 2.62
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci (2011) 2.61
Myelination and the trophic support of long axons. Nat Rev Neurosci (2010) 2.47
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry (2010) 2.44
Poststroke dementia. Lancet Neurol (2005) 2.41
Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci (2011) 2.40
Synaptic energy use and supply. Neuron (2012) 2.40
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol (2011) 2.37
Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke (2011) 2.37
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol (2009) 2.33
Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatry (2011) 2.32
Cerebral microinfarcts: the invisible lesions. Lancet Neurol (2012) 2.31
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol (2010) 2.31
Hypertension and cerebrovascular dysfunction. Cell Metab (2008) 2.30
Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke (2009) 2.30
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci U S A (2008) 2.27
Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Ann Neurol (2010) 2.25
Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology (2012) 2.23
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci (1999) 2.21
Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment. Stroke (2008) 2.21
Promising strategies for the prevention of dementia. Arch Neurol (2009) 2.14
Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol (2011) 2.14
Clinical-neuropathologic findings in multi-infarct dementia: a report of six autopsied cases. Neurology (1997) 2.13
Brain microvascular accumulation and distribution of the NOTCH3 ectodomain and granular osmiophilic material in CADASIL. J Neuropathol Exp Neurol (2013) 2.12
Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet (1999) 2.11
Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. J Neurosci (1992) 2.11
Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology (2002) 2.09
Vascular aspects of multiple sclerosis. Lancet Neurol (2011) 2.09
Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A (2008) 2.06
Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Ann Neurol (2009) 1.98
Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry (2009) 1.97
The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nat Neurosci (2013) 1.92
Review: cerebral microvascular pathology in ageing and neurodegeneration. Neuropathol Appl Neurobiol (2011) 1.91
Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J Immunol (1998) 1.91
Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J Neurosci (2009) 1.89
The neurovascular link in health and disease: molecular mechanisms and therapeutic implications. Neuron (2011) 1.85
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol (2008) 1.83
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun (2012) 1.82
Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain (2011) 1.82
Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J Cereb Blood Flow Metab (2007) 1.79
Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications. J Hypertens (2011) 1.76
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res (2004) 1.74
Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter. Radiology (2004) 1.72