Published in J Biol Chem on April 15, 1989
Nomenclature and classification of purinoceptors. Pharmacol Rev (1994) 5.32
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. J Med Chem (1993) 1.84
Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors. Biochem J (1992) 1.57
Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol (2002) 1.49
Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals. Br J Pharmacol (1993) 1.11
A nucleotide receptor in vascular endothelial cells is specifically activated by the fully ionized forms of ATP and UTP. Biochem J (1992) 1.10
Characterization of diadenosine tetraphosphate (Ap4A) binding sites in cultured chromaffin cells: evidence for a P2y site. Br J Pharmacol (1991) 1.06
Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes. Drug Dev Res (1994) 1.04
Sensitivity of G-protein involved in endothelin-1-induced Ca2+ influx to pertussis toxin in porcine endothelial cells in situ. Br J Pharmacol (1994) 1.03
High- and low-affinity binding sites for [3H]-alpha, beta-methylene ATP in rat urinary bladder membranes. Br J Pharmacol (1990) 1.03
ATP activates P2x-contracting and P2y-relaxing purinoceptors in the smooth muscle of mouse vas deferens. Br J Pharmacol (1992) 1.00
Characterization of the effects of adenosine 5'-[beta-thio]-diphosphate in rat liver. Br J Pharmacol (1993) 0.95
SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2-THIO DERIVATIVES OF ATP. Nucleosides Nucleotides (1993) 0.90
P2-, but not P1-purinoceptors mediate formation of 1, 4, 5-inositol trisphosphate and its metabolites via a pertussis toxin-insensitive pathway in the rat renal cortex. Br J Pharmacol (1990) 0.86
ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells. J Clin Invest (1991) 0.83
High affinity P2x-purinoceptor binding sites for [35S]-adenosine 5'-O-[3-thiotriphosphate] in rat vas deferens membranes. Br J Pharmacol (1996) 0.82
Evidence that [3H]-alpha,beta-methylene ATP may label an endothelial-derived cell line 5'-nucleotidase with high affinity. Br J Pharmacol (1995) 0.79
Study of the mechanisms involved in adenosine-5'-O-(2-thiodiphosphate) induced relaxation of rat thoracic aorta and pancreatic vascular bed. Br J Pharmacol (1996) 0.79
Characterization of the binding of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to rat liver cell membranes. Biochem J (1996) 0.79
P2U receptor is linked to cytosolic Ca2+ transient and release of vasorelaxing factor in bovine endothelial cells in situ. J Physiol (1996) 0.79
The turkey erythrocyte beta-adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein alpha subunits. Biochem J (1994) 0.75
The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance. Am J Med (1996) 6.49
Nomenclature and classification of purinoceptors. Pharmacol Rev (1994) 5.32
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98
Randomised comparison of percutaneous endoscopic gastrostomy and nasogastric tube feeding in patients with persisting neurological dysphagia. BMJ (1992) 4.32
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol (1997) 3.22
Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem (1995) 3.10
Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J Biol Chem (2000) 2.86
Dental practitioners and ill health retirement: causes, outcomes and re-employment. Br Dent J (2010) 2.83
Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. Pharmacol Rev (1983) 2.62
Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score. Gut (2005) 2.62
Do in vitro susceptibility data predict the microbiologic response to amphotericin B? Results of a prospective study of patients with Candida fungemia. J Infect Dis (1998) 2.61
Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J (1997) 2.49
Guidelines on small bowel enteroscopy and capsule endoscopy in adults. Gut (2008) 2.28
A comparison of seven tests for serological diagnosis of tuberculosis. J Clin Microbiol (2000) 2.27
Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. J Biol Chem (1989) 2.23
Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem (2000) 2.19
Methicillin-resistant S. aureus in the suburbs. N Z Med J (1998) 2.13
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor. Br J Pharmacol (1996) 2.12
L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells. Biochem J (1988) 2.10
Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol (1996) 2.10
Therapeutic approaches in patients with candidemia. Evaluation in a multicenter, prospective, observational study. Arch Intern Med (1996) 2.09
Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol Sci (1997) 2.09
Correlation models for childhood epidemics. Proc Biol Sci (1997) 2.06
Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells. Mol Pharmacol (1991) 2.00
Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. J Biol Chem (1997) 1.99
Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate. Biochem J (1987) 1.98
Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network. J Cell Biol (1997) 1.97
Phospholipase D signaling is essential for meiosis. Proc Natl Acad Sci U S A (1995) 1.95
Combination drug therapy in rheumatoid arthritis. J Rheumatol (1996) 1.95
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process. J Biol Chem (1980) 1.95
Association of serotypes of Streptococcus pneumoniae with disease severity and outcome in adults: an international study. Clin Infect Dis (2007) 1.87
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem (2000) 1.85
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. J Med Chem (1993) 1.84
The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Biochemistry (1995) 1.84
Prospective study of 424 cases of Staphylococcus aureus bacteraemia: determination of factors affecting incidence and mortality. Intern Med J (2001) 1.83
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. Biochem J (1985) 1.83
Antimicrobial resistance and clinical outcome of Bacteroides bacteremia: findings of a multicenter prospective observational trial. Clin Infect Dis (2000) 1.83
Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. J Biol Chem (1987) 1.82
Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol (1995) 1.81
Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br J Pharmacol (1998) 1.80
Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry (1998) 1.80
Nosocomial acquisition of Burkholderia gladioli in patients with cystic fibrosis. Am J Respir Crit Care Med (1997) 1.79
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors. Br J Pharmacol (1994) 1.77
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C. Mol Pharmacol (1994) 1.76
Agonist action of adenosine triphosphates at the human P2Y1 receptor. Mol Pharmacol (1998) 1.74
Dental practitioners and ill health retirement: a qualitative investigation into the causes and effects. Br Dent J (2010) 1.74
Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem (1996) 1.71
Relocalization of phospholipase D activity mediates membrane formation during meiosis. J Cell Biol (1998) 1.69
Evaluation of the tuberculin gamma interferon assay: potential to replace the Mantoux skin test. J Clin Microbiol (1999) 1.67
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. EMBO J (2001) 1.67
Prevention of staphylococcal shunt infections by continuous vancomycin prophylaxis. Am J Med Sci (1971) 1.65
A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor. Mol Pharmacol (1997) 1.63
Quantitation of extracellular UTP using a sensitive enzymatic assay. Br J Pharmacol (1999) 1.61
Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors. J Med Chem (1998) 1.61
Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem (1998) 1.61
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors. Neuropharmacology (1997) 1.59
The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. J Biol Chem (1999) 1.54
Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes. EMBO J (1999) 1.54
Experience with mustard gas casualties. Lancet (1991) 1.52
Purification of erythropoietin-responsive cells by immune hemolysis. Proc Natl Acad Sci U S A (1972) 1.50
Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s). Mol Pharmacol (1982) 1.47
Molecular analysis of mammalian phospholipase D2. J Biol Chem (1999) 1.47
Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J Biol Chem (1998) 1.47
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase. Biochem J (1988) 1.44
ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol Pharmacol (2000) 1.44
Twenty-eight cases of human heart-lung transplantation. Lancet (1986) 1.44
The orthodontic condition of children in the United Kingdom, 2003. Br Dent J (2006) 1.42
Candida infective endocarditis. Eur J Clin Microbiol Infect Dis (2008) 1.41
Mammalian phospholipase D structure and regulation. Biochim Biophys Acta (1999) 1.41
Is there a differential in the dental health of new recruits to the British Armed Forces? A pilot study. Br Dent J (2011) 1.39
Simultaneous Streptococcus pneumoniae, Giardia lamblia and Campylobacter pylori infection: an adult presentation of X-linked hypogammaglobulinaemia. Scott Med J (1989) 1.38
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase. Mol Pharmacol (1982) 1.36
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. J Pharmacol Exp Ther (1993) 1.36
Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival. Science (2004) 1.33
Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. J Biol Chem (1994) 1.33
Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking. J Med Chem (2001) 1.32
The molecular nature of the F-actin binding activity of aldolase revealed with site-directed mutants. J Biol Chem (1996) 1.32
Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway. J Biol Chem (1995) 1.30
Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists. J Biol Chem (1997) 1.30
Hepatic granulomas: a 10 year single centre experience. J Clin Pathol (2003) 1.30
Effect of monolayer surface pressure on the activities of phosphoinositide-specific phospholipase C-beta 1, -gamma 1, and -delta 1. Biochemistry (1994) 1.29
Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists. Biochem J (1987) 1.28
Fluorescently labeled neomycin as a probe of phosphatidylinositol-4, 5-bisphosphate in membranes. Biochim Biophys Acta (2000) 1.27
Adenosine receptors on human airway epithelia and their relationship to chloride secretion. Br J Pharmacol (1992) 1.27
Non-carious tooth conditions in children in the UK, 2003. Br Dent J (2006) 1.27
Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. Biochem J (1985) 1.27
Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate. Br J Pharmacol (1996) 1.27
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin. Biochem J (1987) 1.26
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors. Science (1980) 1.25
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J Med Chem (1999) 1.25
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. Mol Pharmacol (1985) 1.24
Functional association between Arf and RalA in active phospholipase D complex. Proc Natl Acad Sci U S A (1998) 1.24
The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. Br J Pharmacol (2000) 1.23
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. J Biol Chem (1987) 1.23
Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. J Biol Chem (1979) 1.23
In vitro study of beta-adrenergic receptors. Annu Rev Pharmacol Toxicol (1977) 1.22
Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. J Biol Chem (1983) 1.22