Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

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Published in J Exp Med on June 23, 2014

Authors

Matthias Canault1, Dorsaf Ghalloussi1, Charlotte Grosdidier1, Marie Guinier2, Claire Perret3, Nadjim Chelghoum2, Marine Germain3, Hana Raslova4, Franck Peiretti1, Pierre E Morange1, Noemie Saut1, Xavier Pillois5, Alan T Nurden6, François Cambien3, Anne Pierres7, Timo K van den Berg8, Taco W Kuijpers8, Marie-Christine Alessi9, David-Alexandre Tregouet3

Author Affiliations

1: Institut National de la Santé et de la Recherche Médicale (Inserm), UMR_S 1062, 13005 Marseille, France Inra, UMR_INRA 1260, 13005 Marseille, France Aix Marseille Université, 13005 Marseille, France.
2: Post-Genomic Platform of Pitié-Salpêtrière (P3S), Pierre and Marie Curie University, F-75013 Paris, France.
3: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, F-75013 Paris, France Inserm, UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases, F-75013 Paris, France ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France.
4: Hématopoïèse Normale et Pathologique, Inserm Médicale U1009, 94805 Villejuif, France.
5: LIRYC, Plateforme Technologique et d'Innovation Biomédicale, Hôpital Xavier Arnozan, Pessac, France Inserm, UMR_1034, 33600 Pessac, France.
6: Inserm, UMR_1034, 33600 Pessac, France.
7: Aix Marseille Université, 13005 Marseille, France Inserm, UMR_1067, 13288 Marseille, France CNRS UMR_7333, 13288 Marseille, France.
8: Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
9: Institut National de la Santé et de la Recherche Médicale (Inserm), UMR_S 1062, 13005 Marseille, France Inra, UMR_INRA 1260, 13005 Marseille, France Aix Marseille Université, 13005 Marseille, France marie-christine.alessi@univ-amu.fr.

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