Published in J Biol Chem on June 24, 2014
Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study. Prostaglandins Leukot Essent Fatty Acids (2015) 0.82
Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid. Mol Biol Evol (2016) 0.81
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque. Diabetes Metab Syndr Obes (2016) 0.80
Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver. J Lipid Res (2015) 0.80
Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis. Curr Opin Clin Nutr Metab Care (2016) 0.77
Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior. Psychiatr Genet (2016) 0.76
PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c. Nucleic Acids Res (2016) 0.76
Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype. J Clin Med (2016) 0.76
Selection in Europeans on fatty acid desaturases associated with dietary changes. Mol Biol Evol (2017) 0.75
Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes. Eur J Pharmacol (2016) 0.75
Identification of sequence variants influencing immunoglobulin levels. Nat Genet (2017) 0.75
Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. PLoS One (2017) 0.75
Sex Differences in Blood HDL-c, the Total Cholesterol/HDL-c Ratio, and Palmitoleic Acid are Not Associated with Variants in Common Candidate Genes. Lipids (2017) 0.75
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem (2000) 8.86
Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr (2005) 6.50
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell (1991) 5.84
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet (2008) 5.23
Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet (2006) 4.13
Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr (2011) 4.03
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res (2009) 2.71
Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am J Clin Nutr (2006) 2.63
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J Biol Chem (1999) 2.49
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr (2008) 2.42
Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study. Circulation (2004) 2.20
Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J Biol Chem (1999) 2.19
SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids (2008) 2.02
Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol (1999) 1.98
METABOLISM OF GLYCEROLIPIDS. VI. SPECIFICITIES OF ACYL COENZYME A: PHOSPHOLIPID ACYLTRANSFERASES. J Biol Chem (1965) 1.98
Structure and expression of fatty acid desaturases. Biochim Biophys Acta (1998) 1.82
Phospholipase A(2) regulation of arachidonic acid mobilization. FEBS Lett (2002) 1.76
Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Br J Nutr (2008) 1.69
alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. Am J Clin Nutr (2007) 1.53
Maintenance of lower proportions of (n - 6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n - 3) fatty acids. Biochim Biophys Acta (1992) 1.50
Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr (2010) 1.46
Essentiality of fatty acids. Lipids (1999) 1.44
An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3. J Lipid Res (2009) 1.42
Remodeling of arachidonate-containing phosphoglycerides within the human neutrophil. J Biol Chem (1986) 1.37
Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem (2009) 1.36
The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet (2011) 1.35
Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot Essent Fatty Acids (2003) 1.35
11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci U S A (1986) 1.35
Adaptive evolution of the FADS gene cluster within Africa. PLoS One (2012) 1.34
Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr (2011) 1.20
Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax (1991) 1.20
Biochemistry of essential fatty acids. Prog Lipid Res (1981) 1.19
Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine bone marrow cells. J Lipid Res (2006) 1.19
Control of arachidonate levels within inflammatory cells. Biochim Biophys Acta (1996) 1.18
Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. J Mol Neurosci (2001) 1.18
The measurement of superoxide anion production by granulocytes In whole blood. A clinical test for the evaluation of phagocyte function and serum opsonic capacity. Eur J Clin Invest (1983) 1.03
Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. Prostaglandins Leukot Essent Fatty Acids (2012) 0.99
Enhanced oxidative stress in coronary heart disease and chronic heart failure as indicated by an increased 8-epi-PGF(2alpha). Eur J Heart Fail (2005) 0.94
Dynamics of arachidonic acid mobilization by inflammatory cells. Biochim Biophys Acta (2011) 0.93
DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS One (2014) 0.89
Platelet-activating factor and leukotriene biosynthesis in whole blood. A model for the study of transcellular arachidonate metabolism. J Immunol (1989) 0.88
Interactions between the APOA5 -1131T>C and the FEN1 10154G>T polymorphisms on ω6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease. J Lipid Res (2010) 0.87
Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin. Prostaglandins Leukot Essent Fatty Acids (2012) 0.85
Humans, lipids and evolution. Lipids (1992) 0.81
Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung. Biochem J (1998) 0.81
Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2. Bioorg Med Chem (2006) 0.80
Radioimmunoassay for 11-dehydro-TXB2: a method for monitoring thromboxane production in vivo. Prostaglandins (1986) 0.77