TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites.

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🔗 View Article (PMC 4123294)

Published in Cell Res on June 27, 2014

Authors

Hui Yang1, Huaipeng Lin1, Haiyan Xu2, Lei Zhang3, Lu Cheng4, Bo Wen4, Jianyong Shou2, Kunliang Guan5, Yue Xiong6, Dan Ye1

Author Affiliations

1: Molecular and Cell Biology Lab of Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College, College of Life Science, Fudan University, Shanghai 200032, China.
2: China Novartis Institutes for BioMedical Research, Shanghai, China.
3: Department of Chemistry, Institute of Stem Cell Research and Regenerative Medicine, Fudan University, Shanghai 200032, China.
4: Department of Biochemistry and Molecular Biology, Institute of Stem Cell Research and Regenerative Medicine, Fudan University, Shanghai 200032, China.
5: 1] Molecular and Cell Biology Lab of Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College, College of Life Science, Fudan University, Shanghai 200032, China [2] Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA.
6: 1] Molecular and Cell Biology Lab of Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College, College of Life Science, Fudan University, Shanghai 200032, China [2] Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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