Published in Dig Dis Sci on July 01, 2014
Mammalian MAP kinase signalling cascades. Nature (2001) 18.89
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15
Differential regulation and properties of MAPKs. Oncogene (2007) 6.36
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J (1998) 5.70
MAP kinases. Chem Rev (2001) 4.70
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology (2004) 4.05
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell (2004) 3.94
Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer (2004) 3.83
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev (2012) 3.62
Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol (2003) 3.46
The enteric nervous system. N Engl J Med (1996) 3.02
The pathobiology of mucositis. Nat Rev Cancer (2004) 2.99
Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer after moderately emetogenic chemotherapy. J Clin Oncol (2005) 2.86
Neuroendocrine pharmacology of stress. Eur J Pharmacol (2003) 2.77
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol (2011) 2.75
Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. Dig Dis Sci (2013) 2.70
Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat Immunol (2000) 2.59
Psychoneuroimmunology: interactions between the nervous system and the immune system. Lancet (1995) 2.57
Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut (2005) 2.20
The role of substance P in inflammatory disease. J Cell Physiol (2004) 2.19
The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem (1999) 2.11
The neurobiology of stress and gastrointestinal disease. Gut (2000) 2.09
Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst (2010) 1.86
Substance p. Int J Biochem Cell Biol (2001) 1.70
Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol (1998) 1.70
Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol Psychiatry (1999) 1.62
Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. Int J Radiat Oncol Biol Phys (2007) 1.61
Neuroendocrine-immune interactions. N Engl J Med (1993) 1.50
Key role of mast cells and their major secretory products in inflammatory bowel disease. World J Gastroenterol (2004) 1.48
ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cell Signal (2006) 1.41
Time- and dose-related changes in the expression of substance P in salivary glands in response to fractionated irradiation. Int J Radiat Oncol Biol Phys (1995) 1.38
Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans. Psychosom Med (1997) 1.34
Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. FASEB J (2004) 1.31
A biological approach to mucositis. J Support Oncol (2004) 1.29
Mast cell tumor necrosis factor alpha production is regulated by MEK kinases. Proc Natl Acad Sci U S A (1997) 1.28
Comprehensive immunofluorescence and lectin binding analysis of vibrissal follicle sinus complex innervation in the mystacial pad of the rat. J Comp Neurol (1997) 1.28
Oral mucositis. Anticancer Drugs (2011) 1.28
Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. Am J Pathol (2003) 1.22
Substance P receptor expression in intestinal epithelium in clostridium difficile toxin A enteritis in rats. Am J Physiol (1998) 1.21
Suggestive evidence for a direct innervation of mucosal mast cells. Neuroscience (1983) 1.21
Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells. Biochim Biophys Acta (2003) 1.16
The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy. Crit Rev Oral Biol Med (2002) 1.15
4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis. J Biol Chem (1999) 1.12
Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential. CNS Drugs (2005) 1.12
Glucocorticoids and inflammation revisited: the state of the art. NIH clinical staff conference. Neuroimmunomodulation (2003) 1.11
Does variability in normal tissue reactions after radiotherapy have a genetic basis--where and how to look for it? Radiother Oncol (2002) 1.08
Targets of glucocorticoid action on TNF-alpha release by macrophages. Inflamm Res (2001) 1.08
Substance P (neurokinin-1) receptor is a marker of human mucosal but not peripheral mononuclear cells: molecular quantitation and localization. J Immunol (1998) 1.08
Substance P: structure, function, and therapeutics. Curr Top Med Chem (2004) 1.08
Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis. Exp Biol Med (Maywood) (2009) 1.07
Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma. J Neurosci (1990) 1.07
Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. Oral Oncol (2006) 1.07
Immunomodulatory properties of substance P: the gastrointestinal system as a model. Ann N Y Acad Sci (2006) 1.06
Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. Am J Physiol Cell Physiol (2008) 1.06
Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry (1991) 1.06
Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin. Brain Behav Immun (2005) 1.04
Psychosocial stress and inflammation in cancer. Brain Behav Immun (2012) 1.02
Control of gastrointestinal motility by the "gut brain"--the enteric nervous system. J Pediatr Gastroenterol Nutr (2005) 1.00
Emerging evidence on the pathobiology of mucositis. Support Care Cancer (2013) 0.99
Probing the effects of stress mediators on the human hair follicle: substance P holds central position. Am J Pathol (2007) 0.97
Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies. J Gen Physiol (1998) 0.97
Hair-cycle-associated remodeling of the peptidergic innervation of murine skin, and hair growth modulation by neuropeptides. J Invest Dermatol (2001) 0.97
c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability. J Biol Chem (2003) 0.96
Fc epsilonRI-mediated induction of TNF-alpha gene expression in the RBL-2H3 mast cell line: regulation by a novel NF-kappaB-like nuclear binding complex. J Immunol (1998) 0.96
Hair growth induction by substance P. Lab Invest (1994) 0.96
Induced heteroduplex genotyping of TNF-alpha, IL-1beta, IL-6 and IL-10 polymorphisms associated with transcriptional regulation. Cytokine (1999) 0.95
A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage. Cancer Metastasis Rev (2006) 0.95
Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells. Cytokine (2002) 0.93
Tachykinins regulate the function of platelets. Blood (2004) 0.93
Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation. World J Gastroenterol (2007) 0.93
Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med (1993) 0.93
Expression of substance P and neurokinin-1-receptor in laryngeal cancer: linking chronic inflammation to cancer promotion and progression. Histopathology (2009) 0.91
Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn's disease and diverticular disease: a role for hemokinin-1? Neurogastroenterol Motil (2011) 0.91
Molecular mechanisms of corticosteroids in allergic diseases. Allergy (2001) 0.90
Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease. Am J Gastroenterol (1992) 0.90
Involvement of substance P, mast cells, TNF-alpha and ICAM-1 in the infiltration of inflammatory cells in human periapical granulomas. J Oral Pathol Med (2002) 0.90
Effect of substance P on histamine secretion from gut mucosa in inflammatory bowel disease. Scand J Gastroenterol (1999) 0.88
Substance P selectively activates TNF-alpha mRNA in rat uterine immune cells: a neuroimmune link. Neuroreport (1997) 0.86
Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat. Exp Biol Med (Maywood) (2010) 0.85
Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils. Neuropharmacology (2003) 0.85
Substance P and stress-induced changes in macrophages. Ann N Y Acad Sci (1995) 0.84
Substance P regulates the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in cultured human gingival fibroblasts. J Periodontal Res (2007) 0.84
Oral mucositis in head and neck cancer: risk, biology, and management. Am Soc Clin Oncol Educ Book (2013) 0.84
Cell proliferation associated with actions of the substance P/NK-1 receptor complex in keratocystic odontogenic tumours. Oral Oncol (2008) 0.83
Interaction between host cells and microbes in chemotherapy-induced mucositis. Nutrients (2013) 0.81
The Damon System and release of substance P in gingival crevicular fluid during orthodontic tooth movement in adults. World J Orthod (2009) 0.81
A role for the substance P/NK-1 receptor complex in cell proliferation and apoptosis in oral lichen planus. Oral Dis (2008) 0.80
Bilateral irradiation of head and neck induces an enhanced expression of substance P in the parasympathetic innervation of the submandibular gland. Neuroscience (1992) 0.80
Cytokines and their receptors: molecular mechanism of interleukin-6 gene repression by glucocorticoids. J Am Soc Nephrol (1992) 0.80
Inhibitory effect of neuraminidase on SP-induced histamine release and TNF-alpha mRNA in rat mast cells: evidence of a receptor-independent mechanism. J Neuroimmunol (1997) 0.79
The effect of three different rotary instrumentation systems on substance P and calcitonin gene-related peptide expression in human periodontal ligament. J Endod (2010) 0.79
Association of oral mucositis with quality of life and symptom clusters in patients with solid tumors receiving chemotherapy. Support Care Cancer (2011) 0.78
Parallel increase in substance P and VIP in rat duodenum in response to irradiation. Peptides (2000) 0.78
Alterations in receptors for sensory neuropeptides in human inflammatory bowel disease. Adv Exp Med Biol (1991) 0.77
Effect of substance P on uterine mast cell cytokine release during the reproductive cycle. J Neuroimmunol (1995) 0.76
Substance P (NK1) receptor in relation to substance P innervation in rat duodenum after irradiation. Regul Pept (2001) 0.76
Involvement of tachykinins in intestinal inflammation. Curr Pharm Des (2001) 0.76
Idiopathic dental pulp calcifications in a tertiary care setting in South India. J Conserv Dent (2013) 0.78
Reflectory trismus in head and neck cancer. Oral Oncol (2013) 0.78
Oral Helicobacter pylori infection and the risk of oral cancer. Oral Oncol (2013) 0.77
Tachykinin Peptide, substance p, and its receptor have a significant role in tissue reactions induced by cytotoxic therapy. Dig Dis Sci (2014) 0.75
An empirical mucosal toxicity measuring tool would elucidate the pattern of mucosal ulceration in cytotoxic therapy. Oral Oncol (2013) 0.75