Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.

PubWeight™: 2.59‹?› | Rank: Top 1%

🔗 View Article (PMID 11062498)

Published in Nat Immunol on November 01, 2000

Authors

Y Zhang1, L Lu, C Furlonger, G E Wu, C J Paige

Author Affiliations

1: Ontario Cancer Institute, Princess Margaret Hospital, University Health Network and Department of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada, M5G 2M9.

Articles citing this

Mast cells and inflammation. Biochim Biophys Acta (2010) 1.91

Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12. Blood (2013) 1.48

Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev (2014) 1.40

Future innovations in anti-platelet therapies. Br J Pharmacol (2008) 1.13

A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. Proc Natl Acad Sci U S A (2004) 1.11

Tachykinins and tachykinin receptors in human uterus. Br J Pharmacol (2003) 1.08

Evaluation of chronic urticaria in patients with Hashimoto thyroiditis. J Clin Immunol (2001) 1.03

BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J Immunol (2010) 0.99

Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol (2011) 0.96

Biological and Pharmacological Aspects of the NK1-Receptor. Biomed Res Int (2015) 0.93

Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood (2007) 0.92

Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions. Br J Clin Pharmacol (2014) 0.91

Hemokinin 1 is a full agonist at the substance P receptor. Nat Immunol (2001) 0.91

Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc Natl Acad Sci U S A (2003) 0.91

Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol (2002) 0.91

The role of neurokinin-1 receptor in the microenvironment of inflammation and cancer. ScientificWorldJournal (2012) 0.90

Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood (2008) 0.90

Stromal cell-free conditions favorable for human B lymphopoiesis in culture. J Immunol Methods (2010) 0.88

The significance of substance P in physiological and malignant haematopoiesis. J Clin Pathol (2006) 0.85

Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire. Immunol Res (2013) 0.85

A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J Neurochem (2009) 0.84

A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 0.84

The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology. Arthritis Res Ther (2014) 0.83

The mammalian tachykinin ligand-receptor system: an emerging target for central neurological disorders. CNS Neurol Disord Drug Targets (2010) 0.82

Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state. Br J Pharmacol (2008) 0.82

Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-κB and p38 MAPK signaling pathways. PLoS One (2012) 0.82

Induction of tachykinin production in airway epithelia in response to viral infection. PLoS One (2008) 0.80

Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS One (2014) 0.80

PepPat, a pattern-based oligopeptide homology search method and the identification of a novel tachykinin-like peptide. Mamm Genome (2003) 0.80

Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse. PLoS One (2013) 0.79

Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases. Mediators Inflamm (2017) 0.79

Expression and function of human hemokinin-1 in human and guinea pig airways. Respir Res (2010) 0.78

Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses. J Allergy Clin Immunol (2014) 0.78

The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation. PLoS One (2015) 0.78

Tachykinins and Neurokinin Receptors in Bone Marrow Functions: Neural-Hematopoietic Link. J Receptor Ligand Channel Res (2010) 0.77

Cocoa polyphenols and fiber modify colonic gene expression in rats. Eur J Nutr (2016) 0.76

Understanding how pre-B cells come of age. Nat Immunol (2000) 0.75

Mas-related G protein coupled receptor-X2: A potential new target for modulating mast cell-mediated allergic and inflammatory diseases. J Immunobiol (2016) 0.75

The effect of intra-articular botulinum toxin A on substance P, prostaglandin E2, and tumor necrosis factor alpha in the canine osteoarthritic joint. BMC Vet Res (2017) 0.75

Tachykinin peptide, substance P, and its receptor NK-1R play an important role in alimentary tract mucosal inflammation during cytotoxic therapy. Dig Dis Sci (2014) 0.75

Cocoa Diet and Antibody Immune Response in Preclinical Studies. Front Nutr (2017) 0.75

Articles by these authors

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (2000) 64.32

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (1996) 16.92

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature (1991) 5.98

Profound block in thymocyte development in mice lacking p56lck. Nature (1992) 5.48

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science (1995) 5.27

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J (1996) 5.17

Strengthening materials by engineering coherent internal boundaries at the nanoscale. Science (2009) 4.95

Murine B cell leukemia line with inducible surface immunoglobulin expression. J Immunol (1978) 4.93

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J Exp Med (1999) 4.52

The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol (2001) 3.17

Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci U S A (1985) 3.02

A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection. Am J Respir Cell Mol Biol (1991) 2.83

CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood (1997) 2.71

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J (2001) 2.62

Gate-voltage control of chemical potential and weak antilocalization in Bi₂Se₃. Phys Rev Lett (2010) 2.32

A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun (1999) 2.31

Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. J Histochem Cytochem (1993) 2.22

Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18

Cl- channels in CF: lack of activation by protein kinase C and cAMP-dependent protein kinase. Science (1989) 2.12

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci U S A (1991) 2.10

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest (1996) 2.09

Natural cytotoxic cells against solid tumors in mice. I. Strain and age distribution and target cell susceptibility. J Immunol (1978) 2.06

Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nat Genet (1998) 2.04

Bipotential precursors of B cells and macrophages in murine fetal liver. Nature (1992) 2.03

Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells. J Immunol (1983) 1.88

Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation (1996) 1.86

The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma. J Immunol (1986) 1.85

Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells (1995) 1.83

Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol (1996) 1.82

Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J Immunol (1997) 1.81

Randomized clinical trial of the effects of abdominal drainage after elective hepatectomy using the crushing clamp method. Br J Surg (2006) 1.79

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay. EMBO J (1986) 1.77

Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. Proc Natl Acad Sci U S A (1995) 1.77

Demographic and psychosocial correlates of physical activity in late life. Am J Prev Med (2001) 1.75

Role of the laboratory in ensuring global access to ARV treatment for HIV-infected children: consensus statement on the performance of laboratory assays for early infant diagnosis. Open AIDS J (2008) 1.74

Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity (2001) 1.71

The fate of fetal and adult B-cell progenitors grafted into immunodeficient CBA/N mice. J Exp Med (1979) 1.68

Molecular genealogy of some nematode taxa as based on cytochrome c and globin amino acid sequences. Mol Phylogenet Evol (1994) 1.67

Replication of B19 parvovirus in highly enriched hematopoietic progenitor cells from normal human bone marrow. J Virol (1988) 1.62

Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression. J Immunol (1993) 1.60

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Overview of the Rapid Response data. Genes Immun (2009) 1.58

Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Blood (1990) 1.58

Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res (1994) 1.58

Secretion of a lambda 2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region. Cell (1983) 1.57

RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene. Proc Natl Acad Sci U S A (1981) 1.55

Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects. Genes Brain Behav (2003) 1.54

Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. J Biol Chem (1996) 1.53

Pasteurella multocida toxin activates the inositol triphosphate signaling pathway in Xenopus oocytes via G(q)alpha-coupled phospholipase C-beta1. J Biol Chem (1997) 1.53

Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites. J Biol Chem (1992) 1.52

Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol (1999) 1.52

Are dendritic cells the key to liver transplant tolerance? Immunol Today (1999) 1.51

Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation (1995) 1.51

CEST-FISP: a novel technique for rapid chemical exchange saturation transfer MRI at 7 T. Magn Reson Med (2010) 1.50

Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions. J Biol Chem (1997) 1.50

PLAB, a novel placental bone morphogenetic protein. Biochim Biophys Acta (1997) 1.49

Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo. J Immunol (2000) 1.47

Targeted mutagenesis of the POU-domain gene Brn4/Pou3f4 causes developmental defects in the inner ear. J Neurosci (1999) 1.45

Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis. Blood (2000) 1.45

A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger. J Biol Chem (1999) 1.45

Hypothesis: genes which function in a stochastic lineage commitment process are subject to monoallelic expression. Semin Immunol (1999) 1.42

Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells. J Exp Med (1989) 1.42

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41

Natural cytotoxic cells against solid tumors in mice. II. Some characteristics of the effector cells. J Immunol (1978) 1.41

Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J Biol Chem (2001) 1.39

Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7  TeV. Phys Rev Lett (2011) 1.39

Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells. J Exp Med (1985) 1.37

Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J (1992) 1.37

Carbamazepine inhibition of neuronal Na+ currents: quantitative distinction from phenytoin and possible therapeutic implications. Mol Pharmacol (1997) 1.36

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain. Proc Natl Acad Sci U S A (1991) 1.36

New trends of HCV infection in China revealed by genetic analysis of viral sequences determined from first-time volunteer blood donors. J Viral Hepat (2011) 1.35

The influence of S17 stromal cells and interleukin 7 on B cell development. Eur J Immunol (1990) 1.35

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells. Blood (1991) 1.35

Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem (1995) 1.34

Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med (1996) 1.32

Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32

Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Eur J Immunol (1994) 1.32

Genetic dissection of the olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size. Behav Genet (2001) 1.31

Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. J Neurosci (2001) 1.31

Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J Immunol (1998) 1.31

Application of cumulative odds logistic model on risk factors analysis for sexually transmitted infections among female sex workers in Kaiyuan city, Yunnan province, China. Sex Transm Infect (2009) 1.29

Patterns and predictors of personal exposure to indoor air pollution from biomass combustion among women and children in rural China. Indoor Air (2011) 1.28

Calcium signaling in transgenic mice overexpressing cardiac Na(+)-Ca2+ exchanger. J Gen Physiol (1997) 1.28

Characterization of adult human marrow hematopoietic progenitors highly enriched by two-color cell sorting with My10 and major histocompatibility class II monoclonal antibodies. J Immunol (1987) 1.26

Th1/Th2 balance in cancer, transplantation and pregnancy. Springer Semin Immunopathol (1999) 1.26

Overexpression of the cardiac Na+/Ca2+ exchanger increases susceptibility to ischemia/reperfusion injury in male, but not female, transgenic mice. Circ Res (1999) 1.24

Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes. Circ Res (1998) 1.23

Conceptualizing antiretroviral adherence in Beijing, China. AIDS Care (2008) 1.23

A high-mobility two-dimensional electron gas at the spinel/perovskite interface of γ-Al2O3/SrTiO3. Nat Commun (2013) 1.23

Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates. Am J Transplant (2013) 1.22

Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes. J Exp Med (1997) 1.21