Using pharmacokinetic and viral kinetic modeling to estimate the antiviral effectiveness of telaprevir, boceprevir, and pegylated interferon during triple therapy in treatment-experienced hepatitis C virus-infected cirrhotic patients.

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Published in Antimicrob Agents Chemother on June 30, 2014

Authors

Cédric Laouénan1, Patrick Marcellin2, Martine Lapalus3, Feryel Khelifa-Mouri4, Nathalie Boyer4, Fabien Zoulim5, Lawrence Serfaty6, Jean-Pierre Bronowicki7, Michelle Martinot-Peignoux3, Olivier Lada3, Tarik Asselah2, Céline Dorival8, Christophe Hézode9, Fabrice Carrat10, Florence Nicot11, Gilles Peytavin12, France Mentré13, Jeremie Guedj14

Author Affiliations

1: INSERM, IAME, UMR 1137, University Paris Diderot, Sorbonne Paris Cité, Paris, France AP-HP, Hôpital Bichat, Department of Biostatistics, Paris, France cedric.laouenan@inserm.fr.
2: INSERM, CRI Paris Montmartre, UMR 1149, University Paris Diderot, Clichy, France AP-HP, Hôpital Beaujon, Hepatology, Physiopathology and Treatment of Viral Hepatitis, Clichy, France.
3: INSERM, CRI Paris Montmartre, UMR 1149, University Paris Diderot, Clichy, France.
4: AP-HP, Hôpital Beaujon, Hepatology, Physiopathology and Treatment of Viral Hepatitis, Clichy, France.
5: INSERM, UMR 1052, University of Lyon, Lyon, France Hospices Civils de Lyon, Department of Hepatology, Lyon, France.
6: AP-HP, Hôpital Saint-Antoine, Department of Hepatology, Paris, France.
7: INSERM, UMR 954, University of Lorraine, Vandoeuvre-les-Nancy, France Centre Hospitalier Universitaire de Nancy, Department of Hepatology, Vandoeuvre-les-Nancy, France.
8: INSERM, UMR 707, University Pierre et Marie Curie, Paris, France.
9: INSERM, UMR 955, University Paris-Est, Créteil, France AP-HP, Hôpital Henri Mondor, Department of Hepatology, Créteil, France.
10: INSERM, UMR 707, University Pierre et Marie Curie, Paris, France AP-HP, Hôpital Saint-Antoine, Department of Public Health, Paris, France.
11: CHU Toulouse, IFB Purpan, Virology Laboratory, Toulouse, France.
12: INSERM, IAME, UMR 1137, University Paris Diderot, Sorbonne Paris Cité, Paris, France AP-HP, Hôpital Bichat, Department of Clinical Pharmacokinetics, Paris, France.
13: INSERM, IAME, UMR 1137, University Paris Diderot, Sorbonne Paris Cité, Paris, France AP-HP, Hôpital Bichat, Department of Biostatistics, Paris, France.
14: INSERM, IAME, UMR 1137, University Paris Diderot, Sorbonne Paris Cité, Paris, France.

Associated clinical trials:

French Cohort of Therapeutic Failure and Resistances in Patients Treated With a Protease Inhibitor (Telaprevir or Boceprevir), Pegylated Interferon and Ribavirin (CUPIC) | NCT01514890

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